DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myh9 and zip

DIOPT Version :9

Sequence 1:	XP_017949131.2	Gene:	myh9 / 100487997	XenbaseID:	XB-GENE-1002222	Length:	1960	Species:	Xenopus tropicalis
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	2008	Identity:	1184/2008 - (58%)
Similarity:	1538/2008 - (76%)	Gaps:	69/2008 - (3%)

- Green bases have known domain annotations that are detailed below.

Frog     8 KYLYVDRNFVNNPLAQADWAAKKLVWVPSEKHGFEAASVKEEVGDEAIVELAENGKKAKVNKDDI 72
            |||.|:||..|:|..||:|..|:|||||.|..||.|||:|.|.|||..|||||.||:..:.:|||
  Fly    58 KYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELAETGKRVMILRDDI 122

Frog    73 QKMNPPKFSKVEDMSELACLNEASVLHNLKERYYSGLIYTYSGLFCVVINPYKYLPIYSEEIVEM 137
            ||||||||.|||||:||.||||||||||:|:|||||||||||||||||:||||.||||:|:|:|.
  Fly   123 QKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPYKKLPIYTEKIMER 187

Frog   138 YKGKKRHEMPPHIYAITDTAYRSMMQDREDQSILCTGESGAGKTENTKKVIQYLAYVATSH---- 198
            |||.||||:|||::||||:|||:|:.||||||||||||||||||||||||||:|||||.|.
  Fly   188 YKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQFLAYVAASKPKGS 252

Frog   199 --------------------------------------------KSKKEQGELERQLLQANPILE 219
                                                        .|..::||||:||||||||||
  Fly   253 GAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGELEQQLLQANPILE 317

Frog   220 AFGNAKTVKNDNSSRFGKFIRINFDVNGYIVGANIETYLLEKSRAIRQAKEERTFHIFYYLLSGA 284
            |||||||||||||||||||||||||.:|:|.|||||||||||||||||||:||||||||.||:||
  Fly   318 AFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDERTFHIFYQLLAGA 382

Frog   285 GEHLKSDLLLEAYNKYRFLSNGHVTIPGQQDKDLFQETMEAMKIMGFTEEEQIGLLRVVSSVLQL 349
            ....:...:|:....|.|||||.:.:||..|...||.|:::|.|||.|.|:...:.|:||:||..
  Fly   383 TPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDFNSIFRIVSAVLLF 447

Frog   350 GNIAFKKERNTDQASMPDNTAAQKLCHLMGINVNDFTRGILLPRIKVGRDFVQKAQTKEQADFAI 414
            |::.|::|||.|||::||||.|||:.||:|::|.|.||..|.||||||||||.|||||||.:||:
  Fly   448 GSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFVTKAQTKEQVEFAV 512

Frog   415 EALAKATYERMFRWLVMRVNKALDKTKRQGASFIGILDIAGFEIFELNSFEQLCINYTNEKLQQL 479
            ||:|||.|||||:|||.|:|::||:|||||||||||||:||||||||||||||||||||||||||
  Fly   513 EAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQLCINYTNEKLQQL 577

Frog   480 FNHTMFILEQEEYQREGIEWNFIDFGLDLQPCIELIEKPAGPPGILALLDEECWFPKATDKSFVE 544
            ||||||||||||||||||||.||||||||||.|:||:||.   ||:|||||||||||||||:||:
  Fly   578 FNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEECWFPKATDKTFVD 639

Frog   545 KVVQEQGSHSKFQKPKQLKDKADFCIIHYAGKVDYKADEWLLKNMDPLNDNVATLLNQSSDKFVS 609
            |:|.....|.||.| ...:..|||.|:||||:|||.|.:||:|||||||:|:.:||..|.|.||.
  Fly   640 KLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENIVSLLQGSQDPFVV 703

Frog   610 ELWRDVDRIVGLDQVAGMADTALPGAFKTRKGMFRTVGQLYKEQLSKLMATLRNTNPNFVRCIIP 674
            .:|:|.: |||:.|.| :.||.. || :|||||||||..||||||:|||.|||||||||||||||
  Fly   704 NIWKDAE-IVGMAQQA-LTDTQF-GA-RTRKGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIP 764

Frog   675 NHEKKSGKLDAHLVLDQLRCNGVLEGIRICRQGFPNRVVFQEFRQRYEILTPNSIPKGFMDGKQA 739
            ||||::||:||.|||||||||||||||||||||||||:.|||||||||:||||.|||||||||:|
  Fly   765 NHEKRAGKIDAPLVLDQLRCNGVLEGIRICRQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKA 829

Frog   740 CVLMIKALELDSNLYRIGQSKVFFRAGVLAHLEEERDLKITDVIISFQAFCRGYLARKAFAKRQQ 804
            |..||:||||||||||:||||:|||||||||||||||.||:|:|::|||||||:|||:.:.||.|
  Fly   830 CEKMIQALELDSNLYRVGQSKIFFRAGVLAHLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQ 894

Frog   805 QLTAMKVIQRNCAAYLKLRNWQWWRLFTKVKPLLQANRFDEELHAKEVELQKVKELQVSSEQKVS 869
            ||.|:::|||||||||||||||||||:|||||||:..:.:|:|..||.||::|:|...:..:...
  Fly   895 QLNAIRIIQRNCAAYLKLRNWQWWRLYTKVKPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQ 959

Frog   870 EMENVQMMLQQEKMQLQEQLQAEIELCAEAEEMRARLATKKQELEEILHDLESRVEEEEERCQIL 934
            |.|........||..|.|||||||||||||||.|:||..:|||||:::.:||:|:||||||...|
  Fly   960 EYERKYQQALVEKTTLAEQLQAEIELCAEAEESRSRLMARKQELEDMMQELETRIEEEEERVLAL 1024

Frog   935 QADKKKMQHNIVELEEQLEEEEAARQKLQLEKVTVEAKMKKLEEDVLVLEDQNSKLGKEKKLYEE 999
            ..:|||::.||.:||||||||||||||||||||.::||:||.|||:.:.:|||.||.|||||.||
  Fly  1025 GGEKKKLELNIQDLEEQLEEEEAARQKLQLEKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEE 1089

Frog  1000 RIAEFTTNLAEEEEKSKSLAKLKNKHETMISDLEERLRREEKQRQELEKTRRKLEGDSTDLHDQI 1064
            |..:.:..|||||||:|.|||||.|||..||:|||||.::::||||.::::||:|.:..||.:|:
  Fly  1090 RANDLSQTLAEEEEKAKHLAKLKAKHEATISELEERLHKDQQQRQESDRSKRKIETEVADLKEQL 1154

Frog  1065 AELQAQIAELKMQLAKKEEELQAALARVEEESAQKNIALKKIRELESQISELQEDLETERAARNK 1129
            .|.:.|:.|::.||||:||||...|.|::||||.|..|.|..||||||::|:|||||.|:|||.|
  Fly  1155 NERRVQVDEMQAQLAKREEELTQTLLRIDEESATKATAQKAQRELESQLAEIQEDLEAEKAARAK 1219

Frog  1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRTKREQEVTQLKKTLEDEARTHEVQIQEIRQKH 1194
            |||.:|||.|||||||.||.|:||:||||||||:|||||:..|||:||:|...||..:.::|.||
  Fly  1220 AEKVRRDLSEELEALKNELLDSLDTTAAQQELRSKREQELATLKKSLEEETVNHEGVLADMRHKH 1284

Frog  1195 SQAVEELSEQLEQTKRLKGNLEKAKQSLEGERNELANEVKALLQGKGDSEHKRKKVEGQLQELQV 1259
            ||.:..:::|||..::.|..|||||.:||.|..:||.|::::...:.:::.:||:.|.|:.||||
  Fly  1285 SQELNSINDQLENLRKAKTVLEKAKGTLEAENADLATELRSVNSSRQENDRRRKQAESQIAELQV 1349

Frog  1260 KVTEGDRVRAELSEKANRLQVELDNVNSLLSQADGKSIKLGKDFSTLESQLQDTQELLQEETRQK 1324
            |:.|.:|.|:||.||..:||.|.:|:.:.|.:|:.|:....|..|.:||||.:.|:||:||||||
  Fly  1350 KLAEIERARSELQEKCTKLQQEAENITNQLEEAELKASAAVKSASNMESQLTEAQQLLEEETRQK 1414

Frog  1325 LSFSTKLKQMEDEKNGLLEQIEEEEEAKKNLSKQISTLQSQMADMKKKMDENVGSLETVEELKKK 1389
            |..|:||:|:|.||..|.||:||::|||:|..::::.:.:||.::|||.:|:....:.:||.||:
  Fly  1415 LGLSSKLRQIESEKEALQEQLEEDDEAKRNYERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKR 1479

Frog  1390 LQKDLESVNQRFEEKAAAYDKLEKTKTRLQQELDDIAVDLDHQRQIVSNLEKKQKKFDQLLGEEK 1454
            |.||:|::.::.:|..|..|:|:|:|.::|.||:|..::|:.||..|..||||||.||::|.|||
  Fly  1480 LNKDIEALERQVKELIAQNDRLDKSKKKIQSELEDATIELEAQRTKVLELEKKQKNFDKILAEEK 1544

Frog  1455 TISAKYADERDRAEAEAREKETKALALARSLEEALEAKAELERLNKQLRTEMEDLVSSKDDVGKS 1519
            .||.:.|.|||.||.||||||||.|:::|.|:||.:...:||...|.|:.|::||.:::....|:
  Fly  1545 AISEQIAQERDTAEREAREKETKVLSVSRELDEAFDKIEDLENKRKTLQNELDDLANTQGTADKN 1609

Frog  1520 VHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEDKK 1584
            ||||||:|||||.|:.|:|.|.|||||:||.|||||||||||:||:::||||||..::|.:|:|:
  Fly  1610 VHELEKAKRALESQLAELKAQNEELEDDLQLTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKR 1674

Frog  1585 KQLVRQVKEMEAELEDERKQRSVAVAARKKLEMDLKDLEGQIDSANKNREEAIKQLRKLQAQIKD 1649
            :.||:|::::|.||::|||||:.|||::||||.|||::|..::..||.:|:|:|..:|||||:||
  Fly  1675 RGLVKQLRDLETELDEERKQRTAAVASKKKLEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKD 1739

Frog  1650 YQRELDDTRASRDDILSQSKESEKKLKSMEAEMIHMQEELAAAERGKRQAQQERDELADEIANNS 1714
            ..|:.::.:|:::::.:.|||:|:|:|::|||::.:.|:||::||.:|.|:.||||||:|||||:
  Fly  1740 ALRDAEEAKAAKEELQALSKEAERKVKALEAEVLQLTEDLASSERARRAAETERDELAEEIANNA 1804

Frog  1715 GKGALALEEKRRLESRIAQLEEELEEEQGNTELVNDRLKKATLQVDQLNADLNAERSNAQKNENA 1779
            .||:|.::||||||:|||.|||||||||.|:|::.||.:||.||::||..:|..|:||:|||||.
  Fly  1805 NKGSLMIDEKRRLEARIATLEEELEEEQSNSEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENG 1869

Frog  1780 RQQMDRQNKELKTKLQELEGTVKSKFKANITALEAKIAQLEEQLDTETKERQNASKQVRRTEKKL 1844
            |..::|||||||.||.|:|...::|.||.|..||||||.|||||:.|.|||....|..|:.:||:
  Fly  1870 RALLERQNKELKAKLAEIETAQRTKVKATIATLEAKIANLEEQLENEGKERLLQQKANRKMDKKI 1934

Frog  1845 KDVMMQVDDERRNAEQYKDQAEKNNVRMKQLKRQVEEAEEEAQRANAMRRKLQRELEDATETAEA 1909
            |::.|.::||||:.:|:|:|.:|.|.|:|.|||.::|.|||.|:....:||.|||.||..|:.||
  Fly  1935 KELTMNIEDERRHVDQHKEQMDKLNSRIKLLKRNLDETEEELQKEKTQKRKYQRECEDMIESQEA 1999

Frog  1910 MNREVNTLKSKLRRGGDVPFVTRRI----------GRKGVDEAS--DEDLDGKADSGD 1955
            ||||:|:||:||||.|.:...:.|:          |..|.|::|  ||.|||: ||.:
  Fly  2000 MNREINSLKTKLRRTGGIGLSSSRLTGTPSSKRAGGGGGGDDSSVQDESLDGE-DSAN 2056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myh9	XP_017949131.2	Myosin_N	29..68	CDD:397036	24/38 (63%)
		Motor_domain	95..764	CDD:419868	486/716 (68%)
		Myosin_tail_1	842..1921	CDD:396244	564/1078 (52%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	23/36 (64%)
		Myosin_head	133..854	CDD:278492	496/728 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	486/716 (68%)
		Myosin_tail_1	931..2011	CDD:279860	564/1079 (52%)
		Prefoldin	1431..1515	CDD:298833	32/83 (39%)
		FAM76	<1847..1926	CDD:292665	44/78 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1149	1.000	Domainoid score	I16
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2376	1.000	Inparanoid score	I34
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm49537
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.090