DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cacna1s and para

DIOPT Version :9

Sequence 1:XP_031752682.1 Gene:cacna1s / 100485035 XenbaseID:XB-GENE-5823874 Length:1689 Species:Xenopus tropicalis
Sequence 2:NP_001259619.1 Gene:para / 32619 FlyBaseID:FBgn0285944 Length:2145 Species:Drosophila melanogaster


Alignment Length:2031 Identity:476/2031 - (23%)
Similarity:807/2031 - (39%) Gaps:615/2031 - (30%)


- Green bases have known domain annotations that are detailed below.


 Frog    29 RSLFCLGLQNPFRKSCINIVEWKPFEMIILLTIFANCIALAIYLPMPEDDTNSVNTILEKIEYIF 93
            ::::.|...||.|:..|.|:....|.:.|:.||..|||.:.    ||...|      :|..|.||
  Fly   131 KAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILVNCILMI----MPTTPT------VESTEVIF 185

 Frog    94 LFIFTIEAALKIVAYGFILHSDAYLRNCWNILDFTIVSVGLFTIVLEQINKVQGVTAPGGTGFNV 158
            ..|:|.|:|:|::|.||||....|||:.||.|||.::::...|:.::             .| |:
  Fly   186 TGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFVVIALAYVTMGID-------------LG-NL 236

 Frog   159 KALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFMIIIYAIVGKELFSGKMHKTC 223
            .|||.|||||.|:.|:.||.|:.::.::|:::..|..:.:|.:|.:.::|::|.:::.|.:.:.|
  Fly   237 AALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMFSLSVFALMGLQIYMGVLTQKC 301

 Frog   224 ---------------------------YYKATDVIATVEKPSPCSTTGQGRQCAINGSECRGWWP 261
                                       :|...:.|:.   |...:.:|.| ||..:....:|:.|
  Fly   302 IKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISF---PLCGNISGAG-QCDDDYVCLQGFGP 362

 Frog   262 GPNNGITHFDNFGFAMLTVYQCITMEGWTEVLYWVNDAIGNEWPWIYFVSLILLGSFFVLNLVLG 326
            .||.|.|.||:||:|.|:.::.:|.:.|.::...|..|.| .|..::|:.:|.||||:::||:|.
  Fly   363 NPNYGYTSFDSFGWAFLSAFRLMTQDFWEDLYQLVLRAAG-PWHMLFFIVIIFLGSFYLVNLILA 426

 Frog   327 VLSGEFTKEREKAKSRGAFQ----------------KLRE------QQAMD-------------- 355
            :::..:.:.::||:...|.:                ||.|      |.|.|              
  Fly   427 IVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQAQAAADAAAAEEAALHPEMA 491

 Frog   356 ----------------------------------------------------------------- 355
                                                                             
  Fly   492 KSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQRQPAPTTAHQATKVRKVSTTS 556

 Frog   356 --------------------------------------------EDLRGYLDWITHAEVMDPDME 376
                                                        :|.:.:|.:...:..:.|..|
  Fly   557 LSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQDAQQHLPYADDSNAVTPMSE 621

 Frog   377 Q--------------------------------GD--------GFSQLEE--------------- 386
            :                                ||        |.|.:.:               
  Fly   622 ENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGVSTMTKESKLRNRNTRNQSVG 686

 Frog   387 ------GCSETE----------------------------------------------------- 392
                  .|.:|.                                                     
  Fly   687 ATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQTQTVVDMKDVMVLNDIIEQA 751

 Frog   393 ------------SLYE---------------------LEGINKFISFLKQW-----RHWHRLLRR 419
                        |:|.                     |:||:.|..:...|     :.|..|   
  Fly   752 AGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFCVWDCCWVWLKFQEWVSL--- 813

 Frog   420 KCRDLVKSRFFYWFVILIILFNTITIATEHHNQPEWLTKAQDIANQVLLAMFTLEMVLKIYALGF 484
                :|...|...|:.|.|:.||:.:|.:||:..:.:.:.....|....|.|.:|..:|:.|:..
  Fly   814 ----IVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATFAIEATMKLMAMSP 874

 Frog   485 QSYFMSLFNRFDCFVVCTGILEILLVSSNIMSPLGISVLRCIRLLRIFKITRYWTSLNNLVASLL 549
            :.||...:|.||..:|...:||:     .:....|:||||..||||:||:.:.|.:||.|::.:.
  Fly   875 KYYFQEGWNIFDFIIVALSLLEL-----GLEGVQGLSVLRSFRLLRVFKLAKSWPTLNLLISIMG 934

 Frog   550 NSVRSIASLLLLLFLFMIIFALLGMQMFGGKFD-----FEDTEIRRSTFDNFPQSLITVFQILTG 609
            .::.::.:|..:|.:.:.|||::|||:||..:.     |.|.::.|..|.:|..|.:.||::|.|
  Fly   935 RTMGALGNLTFVLCIIIFIFAVMGMQLFGKNYHDHKDRFPDGDLPRWNFTDFMHSFMIVFRVLCG 999

 Frog   610 EDWNSVMYNGIMAYGGPTFPGMFVCI-YFIILFVCGNYILLNVFLAIAVDN-------------- 659
            | |...|::.:       :.|...|| :|:...|.||.::||:|||:.:.|              
  Fly  1000 E-WIESMWDCM-------YVGDVSCIPFFLATVVIGNLVVLNLFLALLLSNFGSSSLSAPTADND 1056

 Frog   660 ---LAEAENLTSAQK-------AKAEERKRKKLARAHPDKSEEEKL------------------- 695
               :|||.|.....|       |...:..|.||.....|:...|:.                   
  Fly  1057 TNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERTNQISWIWSEGKGVCRCISA 1121

 Frog   696 -------------LLAKKLEMK----------AKGEGI------------PTTAK---------- 715
                         :||..|..|          |.|:|:            |..:|          
  Fly  1122 EHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGMEFTIHGDMKNNKPKKSKYLNNATDDDT 1186

 Frog   716 LKIDEFESNVNEIKDPYPSADFPGDDEEEEPEIPISPRPRPLAELQLKE---------------- 764
            ..|:.:.|:.|.   |:......|..|..|.|   ..|.....:|.|.|                
  Fly  1187 ASINSYGSHKNR---PFKDESHKGSAETMEGE---EKRDASKEDLGLDEELDEEGECEEGPLDGD 1245

 Frog   765 ------------------------KAVPM--PDASSFFIFGPTNKFRVLCHRIVNATTFTNFILL 803
                                    |..|:  .|..|.|..|..| .|:...:::....|...::.
  Fly  1246 IIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGN-LRLKTFQLIENKYFETAVIT 1309

 Frog   804 FILLSSISLAAEDPIEPE-SFRNQILAYFDYVFTAIFTTEIALKMTTYGAFLHKGSFCRNYFNIL 867
            .||:||::||.||...|: .....||.|.|.:||.||..|:.:|....|..:    :..|.:..|
  Fly  1310 MILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFKV----YFTNAWCWL 1370

 Frog   868 DLLVVAVSLVSFG---IQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIKTIGNIVL 929
            |.::|.|||::|.   :.:..|...|.:|.||.||||||::|.:|::.||..:..||.:|.|::|
  Fly  1371 DFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVVNALVQAIPSIFNVLL 1435

 Frog   930 VTTLLQFMFSCIGVQLFKGKFYSCTDT--TKMTEE--------ECRGYFIVAKDGDSTQIQLRER 984
            |..:...:|:.:|||||.||::.|.|.  ||::.|        |...|                 
  Fly  1436 VCLIFWLIFAIMGVQLFAGKYFKCEDMNGTKLSHEIIPNRNACESENY----------------- 1483

 Frog   985 IWTHSDFHFDNVLSGMMSLFTISTFEGWPQLLYRAIDSHSEDMGPIYNYRIEIAVFFIIYIILIA 1049
            .|.:|..:||:|.:..:.||.::||:||.|::..||||...|..||....|.:.::|:.:||..:
  Fly  1484 TWVNSAMNFDHVGNAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGS 1548

 Frog  1050 FFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQY----------ALKARPLRRYIPKNQHQ 1104
            ||.:|:|:|.:|..|.||.::...:.|:...:.|...|          .|||.|..|:.|    |
  Fly  1549 FFTLNLFIGVIIDNFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKKPLKAIPRPRWRP----Q 1609

 Frog  1105 YKIWYLVTSSYFEYLMFALIMLNTISLGMQHYGQTAEFSHLSDILNVAFTGIFTVEMVLKLAAFK 1169
            ..::.:||...|:.::...|.||..::.:..|..:..::.:.|.||..|..||:.|.:||:.|.:
  Fly  1610 AIVFEIVTDKKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALR 1674

 Frog  1170 AKGYFGDPWNVFDFLIVIGSIIDVILSEIDTPEPVVTPGSEDTSRISITFFRLFRVM---RLVKL 1231
            .. ||.:|||:||.::||.||:.::||:| ..:..|:|          |..|:.||.   |:::|
  Fly  1675 YH-YFIEPWNLFDVVVVILSILGLVLSDI-IEKYFVSP----------TLLRVVRVAKVGRVLRL 1727

 Frog  1232 LSRGEGVRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIAMVDGTQINRNNNFQTFPQ 1296
            :...:|:||||:....|..||..:.||:.::.||:|:.||..|..:....|  ||...||:||.|
  Fly  1728 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQ 1790

 Frog  1297 AVLVLFRCATGEAWQEILLACSYGKLCDPKSD--FLPGEEYTCGTSFAYFYFISFYMLCAFLI-I 1358
            ::::||:.:|...|..:|.|....:.|||..:  ..||   .||::.....|:..|::.:||| |
  Fly  1791 SMILLFQMSTSAGWDGVLDAIINEEACDPPDNDKGYPG---NCGSATVGITFLLSYLVISFLIVI 1852

 Frog  1359 NLFVAVIMDNFDYLTRD-WSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGK 1422
            |:::|||::|:...|.| ...|.....|.:..||.::|||....|::..:...|..::|||...|
  Fly  1853 NMYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK 1917

 Frog  1423 FCPHRVACKRLVSMNMPLNSDGTVTFNATLFSLVRTALKIKTEGNFEQSNEELRMIIKKIWKRTS 1487
              |::.   :::||::|: ..|.:.:...:...:......:.....|::.|     |.:|..|..
  Fly  1918 --PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARKGNPIEETGE-----IGEIAARPD 1971

 Frog  1488 MKLLDQVIPPIGDDEVTVGKFYAIFLIQEHFRKFKKRQEEYYGYRPKKNN---VEIQAGLRTVEE 1549
            .:..:    |:........:.|...|||..:||.|.|.|....:.|..::   .:..||      
  Fly  1972 TEGYE----PVSSTLWRQREEYCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAG------ 2026

 Frog  1550 EVEPEMQRAISGDLTA 1565
              :|....|..||..|
  Fly  2027 --DPAPDEATDGDAPA 2040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacna1sXP_031752682.1 Ion_trans 50..340 CDD:395416 91/316 (29%)
Ion_trans 427..668 CDD:395416 78/263 (30%)
Ion_trans 794..1071 CDD:395416 97/290 (33%)
Ion_trans 1113..1377 CDD:395416 87/270 (32%)
GPHH 1386..1439 CDD:407139 14/52 (27%)
Ca_chan_IQ 1450..1521 CDD:400901 11/70 (16%)
paraNP_001259619.1 Ion_trans 165..436 CDD:278921 86/299 (29%)
Na_trans_cytopl 515..648 CDD:288761 4/132 (3%)
Ion_trans 835..1028 CDD:278921 60/205 (29%)
Na_trans_assoc 1054..1296 CDD:284034 40/248 (16%)
Ion_trans 1318..1571 CDD:278921 92/273 (34%)
Na_channel_gate 1561..1613 CDD:240441 13/55 (24%)
Ion_trans 1636..1871 CDD:278921 83/251 (33%)
GPHH 1880..1930 CDD:293510 15/54 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.030

Return to query results.
Submit another query.