Protein Alignment SH2D3A and CG9098

DIOPT Version :10

• Sequence 1: NP_001426154.1
• Gene: SH2D3A / 10045
• HGNCID: 16885
• Length: 605
• Species: Homo sapiens
• Sequence 2: NP_608979.2
• Gene: CG9098 / 33840
• FlyBaseID: FBgn0031762
• Length: 944
• Species: Drosophila melanogaster
• Alignment Length: 747
• Identity: 178/747 - (23%)
• Similarity: 281/747 - (37%)
• Gaps: 192/747 - (25%)

Human     6 DGEDLAGQPWYHGLLSRQKAEALLQQNGDFLVRASGSRGGNPVISCRWRGSALHFEVFRVALRPR 70
            |..:|....||||.|.||:||.::|:.||||||...|:..|.|:|||.:.:.|||.:.::.|:|.
  Fly   231 DARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCASQPDNYVLSCRSKAAVLHFVLNKLVLQPE 295

Human    71 PGRPTALFQLEDEQFPSIPALVHSYMTGRRPLSQATGAVVSRPVTWQGPLRRSF---------SE 126
            .......:|.|::.|.::|.|:..|:...:|:|.|:||::..|.....||  ||         ..
  Fly   296 TVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSASGALIQFPCNRTYPL--SFYGHKIVGNQLH 358

Human   127 DTLMDGPARIEPLRARKWSN-----------------SQPADLAHMGRSREDPAGMEAS------ 168
            ..::.|...:.||.:...||                 .|...|:.|..|   ||....|
  Fly   359 TQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFEPQQQQQQQLSPMAGS---PASPHCSPPRARR 420

Human   169 -TMPISALPRTSSDPVLLKAPAPLGTVADSLRASDGQLQAKA-------------------PTKP 213
             ..|...||...........||....|::..:..:.|||.:.                   ||..
  Fly   421 EVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQLQMQELENGNGNGIMRFQTIARCNPTSE 485

Human   214 PR------TPSFELPDASERPPTYCELVPRVPSVQGT----SPSQSCPEPEAPWWEAEE------ 262
            ..      |.|...|:.|.......:.|.|:.|:...    |||.|.| |..|....:|
  Fly   486 QHLESKFTTHSLPRPNTSAAHALRQQAVARISSLARNCSLDSPSDSRP-PSPPPKPRKEPMAAVL 549

Human   263 --------------DEEEENRCFTRPQAEI------------------SFCPHDAPSC------- 288
                          |....:.|....|..:                  ||...|..:.
  Fly   550 AYQASGSDSGNGSGDSALGDACEASVQRGVIIKNPRFMTTSVSNGTLKSFTEFDVLAAEEELFTM 614

Human   289 ------------------LLGP--QNRPLEPQVLHTLRGLFLEHHPGSTALHLLLVDCQATGLLG 333
                              ||.|  :|:||:...|:|.:.:.||..|...|.|:..:|...  .|.
  Fly   615 AIEEVKTASKFDFENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRIDIAL--FLE 677

Human   334 VTRDQRGNMGVSSGLELLTLPHGHHLRLELLERHQTLALAGALAVLGCSGPLEERAAALRGLVEL 398
            ...::.......|||||||||||...|.:::||.|.:.|..|:.:|.|...| :||..|...:::
  Fly   678 EPSNEEDYYLSCSGLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQI 741

Human   399 ALALRPGAAGDLPGLAAVMGALLMPQVRGEQGLEEAGVRVTGKTGEEACSDLFSQVSRLEHTWRQ 463
            |:..:. |.|:|.|..|:|..|.|                             .|:.:|:..|..
  Fly   742 AVETKT-ALGNLFGFCAIMLGLCM-----------------------------QQIQKLDQAWHI 776

Human   464 LRRSHTEAALAFEQELKPLMRALDEGAGPCDPGEVALPHV--------APMVRLLEGEEV----- 515
            ||:.:|::|..||.:|:|.:..::|.:.|..| ...:|||        .|::.::....:
  Fly   777 LRQQYTDSAFTFEAKLRPTLSIMNEASNPQAP-NTTVPHVLLYALLIDRPVMDIINHSNIDDRPA 840

Human   516 -----AGPLDESCERLLRT-----LHGARHMVRDAPKFRKVAAQRLRGFRPNPE--LREALTTGF 568
                 ..|.:...:....|     |..:|..:::...:||.|...|....|..:  |.:|..|.|
  Fly   841 LYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAKIILEDASPRLDELLADAFRTEF 905

Human   569 VRRLLWGSRGAGAPRAERFEKFQRVLGVLSQR 600
            ..:.||||.||.|...:|..|.::||.:::.:
  Fly   906 HVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH2D3A	NP_001426154.1	None
CG9098	NP_608979.2	SAM_1	42..102	CDD:425739
		SH2_BCAR3	233..367	CDD:198200	45/135 (33%)
		RasGEF	660..>797	CDD:470590	48/169 (28%)