Protein Alignment SH2D3C and CG9098

DIOPT Version :10

• Sequence 1: NP_733745.1
• Gene: SH2D3C / 10044
• HGNCID: 16884
• Length: 860
• Species: Homo sapiens
• Sequence 2: NP_608979.2
• Gene: CG9098 / 33840
• FlyBaseID: FBgn0031762
• Length: 944
• Species: Drosophila melanogaster
• Alignment Length: 964
• Identity: 292/964 - (30%)
• Similarity: 433/964 - (44%)
• Gaps: 184/964 - (19%)

Human    23 LSNLPRSFTLRR----------SSASISR-QSHLEPDTFE------ATQDDMVTV-PKSPPAYA- 68
            |.|...|.|:||          |..|||. ...||...:|      :|.||:|.: .|....:.
  Fly    22 LWNFRYSNTVRRREDLAVMVHNSRMSISEWLDLLELQQYEGNLQEFSTVDDVVDITDKELKQFGV 86

Human    69 ----RSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPK-------------PNLVPGGVPDPPG 116
                |...:.|.:|.  |...:::.|.:|...|..|.|:             |..:.|.....||
  Fly    87 RGAHRQRMVNSLLGV--RAKRRQSMNLEAMSSAPRAVPRRKNSCPLVYLGENPQDMAGSGDSGPG 149

Human   117 LEAAKEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGS 181
            :...|...|......::|..:..     |:.|..|...|...:|:.|  .:.:....|..|.|.:
  Fly   150 VITTKSGKVLKQLTFDETSTIYE-----ELRPRSKCNSPHWAIEDSR--MEGYGSSNATTPLATA 207

Human   182 DYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSL 246
            ......:::.|      .|.|.||.||.|.:.:|||||||||.:||:.:|.:|||.||||:||..
  Fly   208 QPSPSEQQEAI------ALKKALEWELSLDARELRSHAWYHGALPRQRAEEIVQREGDFLVRDCA 266

Human   247 TSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQS 311
            :...:|||:||.:...|||.:||:|::....|..:||.||:::||.||.|:.::|||.|.:|..|
  Fly   267 SQPDNYVLSCRSKAAVLHFVLNKLVLQPETVYERVQYQFEEDAFDTVPDLITFYVGSGKPISSAS 331

Human   312 GAIIYCPVNRTFPLRYLEASYG---LG-----------QGSSKPASPVSPSGPKGSHMK------ 356
            ||:|..|.|||:||.:    ||   :|           :|.|...||:..:|..|:.|.
  Fly   332 GALIQFPCNRTYPLSF----YGHKIVGNQLHTQMLAGLRGLSPLNSPMGSNGAVGAGMNATFRFE 392

Human   357 --------------------------RRSVTMTDGLTADKVTRSDG-CPTSTSLPRPRDSIRSCA 394
                                      ||.|.....|...|..||.. .|....|....:.::...
  Fly   393 PQQQQQQQLSPMAGSPASPHCSPPRARREVPPPPRLPCKKQQRSQSLTPAQAMLVSNINKLQEQQ 457

Human   395 LSMDQIPDLH----------SPMSPISESPSSPAYSTVTRVHAAPA--APSATALPASPVARRSS 447
            |.|.::.:.:          :..:|.||......::|    |:.|.  ..:|.||....|||.||
  Fly   458 LQMQELENGNGNGIMRFQTIARCNPTSEQHLESKFTT----HSLPRPNTSAAHALRQQAVARISS 518

Human   448 EPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSY--SDPDSGHYCQLQPPVRGSREWA- 509
            ..:.|...:|     ||..|.:.|...  :..|..::.:|  |..|||:         ||.:.|
  Fly   519 LARNCSLDSP-----SDSRPPSPPPKP--RKEPMAAVLAYQASGSDSGN---------GSGDSAL 567

Human   510 --ATETSSQQ------------ARSYGERLKELSE---NGAPEGDWGKTFTVPIVEV--TSSFNP 555
              |.|.|.|:            :.|.| .||..:|   ..|.|    :.||:.|.||  .|.|:.
  Fly   568 GDACEASVQRGVIIKNPRFMTTSVSNG-TLKSFTEFDVLAAEE----ELFTMAIEEVKTASKFDF 627

Human   556 ATFQSLLIPR-DNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRW 619
            ..|.:||:|. :|:||:...|...|.:|.|...:.||.|:|::|  :|..|......:.......
  Fly   628 ENFVTLLLPSVENKPLDGDALNTFKMMLLETGPKLLAEHITRID--IALFLEEPSNEEDYYLSCS 690

Human   620 GMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFS 684
            |:||||||||:..|.|::||...:.:|:||.||.|.... :||.||.|.||:|.|.:..:||:|.
  Fly   691 GLELLTLPHGKVFREDIIERTQCIKLMVAVTILTCQTDL-DRAQLLSKWIQIAVETKTALGNLFG 754

Human   685 FAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVL-- 747
            |.|:|..|.|.||.:|:|.|..|||::|:.|..:|.||:|.|..:||. ..|...|||.||||
  Fly   755 FCAIMLGLCMQQIQKLDQAWHILRQQYTDSAFTFEAKLRPTLSIMNEA-SNPQAPNTTVPHVLLY 818

Human   748 ------PLITLL---ECDSAPP---EGPEPWGS--TEHGVEVVLAHLEAARTVAHHGGLYHTNAE 798
                  |::.::   ..|..|.   ....||.|  .:.|:.:...||:|:|....:..||..||:
  Fly   819 ALLIDRPVMDIINHSNIDDRPALYHTCIAPWESKADDFGMTINFQHLDASRGFLKNLELYRKNAK 883

Human   799 VKLQGFQAR-PELL-EVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHK 850
            :.|:....| .||| :.|.|||.::.||||.||::....|:.|.:||||.::.|
  Fly   884 IILEDASPRLDELLADAFRTEFHVKFLWGSSGATAKAEDRHNKLEKVLTLMADK 937

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SH2D3C	NP_733745.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	51..117		18/90 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	130..180		9/49 (18%)
		SH2_BCAR3	213..347	CDD:198200	64/147 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..537		59/277 (21%)
		RasGEF	585..>754	CDD:470590	69/179 (39%)
CG9098	NP_608979.2	SAM_1	42..102	CDD:425739	15/61 (25%)
		SH2_BCAR3	233..367	CDD:198200	60/137 (44%)
		RasGEF	660..>797	CDD:470590	57/139 (41%)