DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CHAF1A and Caf1-180

DIOPT Version :9

Sequence 1:	NP_005474.2	Gene:	CHAF1A / 10036	HGNCID:	1910	Length:	956	Species:	Homo sapiens
Sequence 2:	NP_572495.1	Gene:	Caf1-180 / 31801	FlyBaseID:	FBgn0030054	Length:	1183	Species:	Drosophila melanogaster

Alignment Length:	1186	Identity:	300/1186 - (25%)
Similarity:	481/1186 - (40%)	Gaps:	385/1186 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    13 RGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKA--------------------------- 50
            :.||......::.|...||.:|.|||||.  |.|.|.|
  Fly    15 KDAAVPAKSAEKTASGGKKFVQTRLPFKL--LTPGGGAVPTSSSSSSSPATIGSGPVTVILDEDD 77

Human    51 ----------DDMSDDQGT---------SVQSKSPDLEASLDT---------LENNCHVGSD--- 84
                      ||.|..:||         |...::.||.:|:.|         :|:...:..|
  Fly    78 PAPRKRKLSYDDESPSEGTGCSTGQLRRSTSKENLDLASSIATKKVKTTDSVVEDVIELDEDEAD 142

Human    85 -----------------IDFRPKLVNGKG----------PLDNFLRNRIETSIGQS-----TVII 117
                             :..:||...||.          ||.| .|::...|:.:|     |...
  Fly   143 KEIEDQDQLVEAKSSKEVKLKPKKSEGKKGSPAPIQIKLPLVN-KRSKRRKSLKKSEEPLETSTA 206

Human   118 DLTEDSNEQPDSL-VDHNKLN----------SEASPSREAINGQR---------EDTGDQQGLLK 162
            |:.:..:|..|.: :...:||          .|.||...:.:|:.         :|:..|:..:|
  Fly   207 DVAKGDSESSDDIEIIAEELNPQKRQKVQTPREKSPENSSTSGKHTEEVMQKNGKDSKKQEESMK 271

Human   163 AIQNDKLAFPGETLSDIPCKTEEEGVGCGGAGRRGD----------SQECSPRSCPEL------- 210
            |::..|...|         ||.|:       .::.|          ..|.:.:..||:
  Fly   272 AVKESKKEEP---------KTAEQ-------NKKNDQATIDLFMGKKMETNKKDKPEVKTTAKDN 320

Human   211 --------TSGPRMCPRKEQDSWSEAGGILFKGKVPMVVLQDILAVRPPQIKSL-----PATPQG 262
                    .|.|:..|:||.   |:.||   |||..        ..:|.: ||.     .:|.:.
  Fly   321 KKDPLIAEDSKPKEVPKKET---SKTGG---KGKKE--------GAKPAE-KSKKEEKEDSTTKS 370

Human   263 K--------NMTPESEV---LESFPEEDSVLSHSSLSS-------------PSSTSSPEGPP--- 300
            |        |...|.::   .::...||:..||.|:::             .|...|||...
  Fly   371 KKEKADSPANNQKEQQIGVKKKTSEPEDASNSHKSVTAKKDSKKDEASTQVKSDNESPEAAEISM 435

Human   301 --APPKQHSSTSPF-------------PTSTPLRRITKKFV-------KGSTEKNKLRLQRDQER 343
              :..:.:||:|..             |::....|:.:|.:       ||.|.|        |:|
  Fly   436 ILSTSEANSSSSEHEMDADTDTAATDRPSAQKETRLNRKSLPEVTGAPKGLTPK--------QQR 492

Human   344 LGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEK--ELKEKERREKREKDEKEKAEKQRLKEE 406
            |.:|.| :|..|:::||.|| :|.|::.|:.:|::|  |..|||::.|.|:|:||:..|.. |||
  Fly   493 LMEQRK-KAREEKEQKLAEE-RRLKQQDKEHREQQKKQERDEKEQQRKLERDQKEQQRKME-KEE 554

Human   407 RRKERQEALEAKLEEKRK----KEEEKRLREEEKRIKAEKAE------------ITRFFQKPKTP 455
            :.::||..:::|.|||||    |||.:|.::||:|.|.::.|            .::||    .|
  Fly   555 KERKRQAEVDSKNEEKRKRNEAKEEVQRKKDEERRKKEQEREEAEQKKKRAAESFSKFF----VP 615

Human   456 QAPKTLAG------------SCGK---------FAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLL 499
            :.||..:|            ||..         |.||:||:.|:|||..|.:...:..||||.|.
  Fly   616 KQPKCGSGSNNTSYLEHEQSSCDSSKASSQTLAFRPFQIKDDMLLAPIVRNSLGQEQRSQLDGLF 680

Human   500 QQQSGEFS---------------------FLKDLKG--RQPLR-SGPTHVSTRNAD-IFNSDVVI 539
            :.:..|..                     :|.:|..  |:||: .....:..|..| ..:.||.:
  Fly   681 RHRDEEADDEEEEEEQDIVRRKPPNRANLYLSELSSGRRKPLKMQRDVKLQRRTKDEEDDDDVQV 745

Human   540 VERGKGDGVP----ERRKFGRM--KLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEV 598
            ::.....|:|    :.::..||  |.|.|.:|.||.|:|||.||::.|.||.|.|||..|.||||
  Fly   746 IDYLSPAGLPIEVEQPKQLTRMKAKYLHFADNRRPPYYGTWRKKSSSISARRPLAQDKVLFDYEV 810

Human   599 DSDEEWEEEEPGESLSHSEGDDDDDMGED-EDEDDGFFVPHGYLSEDEGVTEECADPENH-KVRQ 661
            |||.||||||||||||.||.:.:.:..|: |:|.:.::||||:||::|...:.....:.| :..|
  Fly   811 DSDCEWEEEEPGESLSASEDEKEKESEEESEEEYNEWYVPHGHLSDEELQNDGDGMEDGHTREAQ 875

Human   662 KLKAKEWDEFLAK--GKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETL--------- 715
            |.|.:...:..|:  .|:.:.::...:|.||.   |..|:..::   |.|.|..|:
  Fly   876 KAKLQVLQQEFAQEMKKQTKKIKARLLGPVWL---DENGNKSEL---FPAIFAHTIDMYACWQVE 934

Human   716 ---------PAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLL--SNH 769
                     |.:::|||:.....:.|::::.||:.|.|||.|....:|.|:.|:.:....  :|.
  Fly   935 PLSLEPPPEPERQDQTPEQPVPLQLDDRLMQQLVRLTHGNRNSKTFLINEYLEYLKTQATAEANQ 999

Human   770 TGSP------------RSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHP 822
            |..|            .|..|..|.||    :||..|.:..|:        .::|..|:||.|..
  Fly  1000 TTLPSKAVLREKFDELASWKTVELSTP----EAAAASANSAKK--------GRKPKKRLCWVVAS 1052

Human   823 QVLQSFQQEHLPVPCQWSY-----VTSVPSAPKED----SGSVPSTGPSQG--------TPISLK 870
            .:|:.||...|.:..||:|     |:..|.|.:::    :.:||:..|:..        ||||
  Fly  1053 DMLEKFQLPDLQLQNQWNYTLTPKVSDGPDAAQQEQSPPADAVPAASPASNQTTNSAPTTPIS-- 1115

Human   871 RKSAGSMCITQFMKKR 886
                |.....|.:|||
  Fly  1116 ----GQTQAGQGVKKR 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CHAF1A	NP_005474.2	Binds to CBX1 chromo shadow domain	1..314		90/482 (19%)
		CAF1-p150_N	1..226	CDD:317891	65/347 (19%)
		Binds to PCNA	1..49		13/35 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..65		9/65 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..155		9/52 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	188..222		8/58 (14%)
		PxVxL motif	233..246		3/12 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..432		67/241 (28%)
		CAF-1_p150	320..479	CDD:314479	66/204 (32%)
		CAF1A	558..>601	CDD:315024	25/42 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	599..639		22/40 (55%)
		Necessary for homodimerization and competence for chromatin assembly	642..678		8/38 (21%)
		Binds to p60	660..956		68/278 (24%)
		CAF1-p150_C2	665..954	CDD:317878	65/273 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..790		8/38 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	844..873		9/40 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	933..956
Caf1-180	NP_572495.1	GBP_C	<491..599	CDD:303769	45/110 (41%)
		coiled coil	573..584	CDD:293879	4/10 (40%)
		CAF1A	770..>814	CDD:289057	26/43 (60%)
		CAF1-p150_C2	947..>1127	CDD:292176	51/197 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	92	1.000	Domainoid score	I7640
eggNOG	1	0.900	-	-		E1_KOG4364
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006059
OrthoInspector	1	1.000	-	-		oto88904
orthoMCL	1	0.900	-	-		OOG6_106916
Panther	1	1.100	-	-	LDO	PTHR15272
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5940
SonicParanoid	1	1.000	-	-		X4979
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.800