DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atp8b5a and DRS2

DIOPT Version :9

Sequence 1:	XP_021332106.1	Gene:	atp8b5a / 100330945	ZFINID:	ZDB-GENE-060531-48	Length:	1205	Species:	Danio rerio
Sequence 2:	NP_009376.2	Gene:	DRS2 / 851207	SGDID:	S000000024	Length:	1355	Species:	Saccharomyces cerevisiae

Alignment Length:	1164	Identity:	464/1164 - (39%)
Similarity:	678/1164 - (58%)	Gaps:	84/1164 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish    10 RKKEKEVE-----RKIRANDREYNSSFKYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYFLFLL 69
            ||...:.|     |.|..||...||||.|:.|.|.|:|||..:|||..||::|.:.||.:||...
Yeast   170 RKNVGDAEGNGEPRVIHINDSLANSSFGYSDNHISTTKYNFATFLPKFLFQEFSKYANLFFLCTS 234

Zfish    70 ILQVIPAISSLSWFTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKVNVLISG--KLTSEKW 132
            .:|.:|.:|..:.:||:..|::||.|:|.|:.|:||.|..||:::||....:....  ....::|
Yeast   235 AIQQVPHVSPTNRYTTIGTLLVVLIVSAMKECIEDIKRANSDKELNNSTAEIFSEAHDDFVEKRW 299

Zfish   133 MNVQVGDIIKLENNQFVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLEAL 197
            ::::|||||::::.:.:.||.::||||||..|.|||||.||||||||:|||...|... .:::.|
Yeast   300 IDIRVGDIIRVKSEEPIPADTIILSSSEPEGLCYIETANLDGETNLKIKQSRVETAKF-IDVKTL 363

Zfish   198 AAFNGEVCCEPPNNRLDRFTGTLTFDTQKYSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKLMQ 262
            ...||:|..|.||:.|..:.||:|.:.::..|..::::|||.|||||.|.||||:|.|.||||::
Yeast   364 KNMNGKVVSEQPNSSLYTYEGTMTLNDRQIPLSPDQMILRGATLRNTAWIFGLVIFTGHETKLLR 428

Zfish   263 NCGKSTFKRTSIDRLMNVLVLFIFALLALMCIILAVGHGIWENYTGSKFNVFLPHEENAA---FS 324
            |...:..|||::::::|..::.:|.:|.::.:|.::|:.|.........:.......|.|   |.
Yeast   429 NATATPIKRTAVEKIINRQIIALFTVLIVLILISSIGNVIMSTADAKHLSYLYLEGTNKAGLFFK 493

Zfish   325 AFLTFWSYIIILNTVVPISLYVSMEVIRLGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIK 389
            .|||||   |:.:.:|||||:|::|:|:...::.|..|.::|:.:||||...||::|.||||||:
Yeast   494 DFLTFW---ILFSNLVPISLFVTVELIKYYQAFMIGSDLDLYYEKTDTPTVVRTSSLVEELGQIE 555

Zfish   390 YIFSDKTGTLTQNIMTFNKCSINGKSYGDVFQHYSGQTLEITEETTP-----VDFSFNGLADPKF 449
            |||||||||||:|||.|..|||.|..|.|          :|.|:.|.     ::..:....|.|.
Yeast   556 YIFSDKTGTLTRNIMEFKSCSIAGHCYID----------KIPEDKTATVEDGIEVGYRKFDDLKK 610

Zfish   450 LFYDHSLVEAVKLELPEVHAFFRLLALCHTCMAEEKKEGHLVYQAQSPDEGALVTAARNFGFVFR 514
            ...|.|..::     |.::.|..|||.|||.:.|.:.:|.:.|||.||||||||....:.|:.|.
Yeast   611 KLNDPSDEDS-----PIINDFLTLLATCHTVIPEFQSDGSIKYQAASPDEGALVQGGADLGYKFI 670

Zfish   515 SRSPETITI--EEMGIQRTYELLAILDFNNVRKRMSVIVRNPEGKLSLYCKGADTIIYERLHPSC 577
            .|.|.::|:  ||.|.::.|:||.|.:||:.|||||.|.|.|:|.:.|:||||||:|.|||....
Yeast   671 IRKPNSVTVLLEETGEEKEYQLLNICEFNSTRKRMSAIFRFPDGSIKLFCKGADTVILERLDDEA 735

Zfish   578 SKLMEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESSVAMEDREEKLDKVYEEIEKD 642
            ::.:|.|..||.::|.||||||.||.:|:.|..:.||...::|::..:::|.||||:....|||:
Yeast   736 NQYVEATMRHLEDYASEGLRTLCLAMRDISEGEYEEWNSIYNEAATTLDNRAEKLDEAANLIEKN 800

Zfish   643 MMLIGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENIGYSCNLLREEMNDVFIVAAH 707
            ::|||||||||||||||..||..|.:|.|||||||||:||||.|||.||.||.|:||.:.|
Yeast   801 LILIGATAIEDKLQDGVPETIHTLQEAGIKIWVLTGDRQETAINIGMSCRLLSEDMNLLII---- 861

Zfish   708 SPEEVRQELRDARLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVNGEYGLVINGHSLAFALESSM 772
                 .:|.||       .||::  |:.::...|..::  ..|......|||:|.||.||||..:
Yeast   862 -----NEETRD-------DTERN--LLEKINALNEHQL--STHDMNTLALVIDGKSLGFALEPEL 910

Zfish   773 ELEFLRTACMCKTVICCRVTPLQKAQVVELVKRYKKAVTLAIGDGANDVSMIKAAHIGVGISGQE 837
            |...|..|.:||.||||||:|||||.||::|||...::.|||||||||||||:|||:||||||.|
Yeast   911 EDYLLTVAKLCKAVICCRVSPLQKALVVKMVKRKSSSLLLAIGDGANDVSMIQAAHVGVGISGME 975

Zfish   838 GMQAVLSSDFSFAQFRFLQRLLLVHGRWSYLRMCKFLRYFFYKNFTFTFVHFWYAFFCGFSAQTV 902
            ||||..|:|.:..||:||::||||||.|||.|:...:.|.||||.......|||.|...||.|::
Yeast   976 GMQAARSADIAVGQFKFLKKLLLVHGSWSYQRISVAILYSFYKNTALYMTQFWYVFANAFSGQSI 1040

Zfish   903 YDEGFITLYNLVYTALPVLGMSLFDQDVNANWSLEFPQLYVPGQLSQYFSKRAFMMCALHSCYSS 967
            .:...::.|||.:|..|...:.:|||.|::.....:||||..||..|:||...|....::..:.|
Yeast  1041 MESWTMSFYNLFFTVWPPFVIGVFDQFVSSRLLERYPQLYKLGQKGQFFSVYIFWGWIINGFFHS 1105

Zfish   968 LVLFFVPYATTYDTARADGRDG--ADYQSFALITQTCLTVTVCVQLGLDLSYWTVVNHLFVWGSL 1030
            .:: |:.....|....|....|  ||:.|:.:...|...:.|..:..|..:.||....:.:.|||
Yeast  1106 AIV-FIGTILIYRYGFALNMHGELADHWSWGVTVYTTSVIIVLGKAALVTNQWTKFTLIAIPGSL 1169

Zfish  1031 GMFFFLTFTMYTDGLFKLRPASFAFIGTARNCLNQPNVWLTVALTALLCVLPVVA---------Y 1086
             :|:.:.|.:|. .:|.....|..:.|..::.......|||      |.|||:.|         |
Yeast  1170 -LFWLIFFPIYA-SIFPHANISREYYGVVKHTYGSGVFWLT------LIVLPIFALVRDFLWKYY 1226

Zfish  1087 RFIY-CQIYPTINDKVRYKMR------QMKEPAPRPRPRLTRRSTRRSGYAFSHAQGYG 1138
            :.:| .:.|..|.:..:|.:.      |..:.|.| :.|..:|..::.|:|||.|:..|
Yeast  1227 KRMYEPETYHVIQEMQKYNISDSRPHVQQFQNAIR-KVRQVQRMKKQRGFAFSQAEEGG 1284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	408/949 (43%)
DRS2	NP_009376.2	ATPase-Plipid	198..1240	CDD:273734	441/1089 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I1639
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820