Protein Alignment atp8b5a and ATP8B1

DIOPT Version :9

• Sequence 1: XP_021332106.1
• Gene: atp8b5a / 100330945
• ZFINID: ZDB-GENE-060531-48
• Length: 1205
• Species: Danio rerio
• Sequence 2: NP_001361314.1
• Gene: ATP8B1 / 5205
• HGNCID: 3706
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1216
• Identity: 646/1216 - (53%)
• Similarity: 822/1216 - (67%)
• Gaps: 89/1216 - (7%)

Zfish    14 KEVERKIRANDREY-------NSSF------KYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYF 65
            ||...:::||||:|       |:.|      |||.|.|||.|||.|:|:|:||||||:|.||.||
Human    60 KECTWQVKANDRKYHEQPHFMNTKFLCIKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYF 124

Zfish    66 LFLLILQVIPAISSLSWFTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKVNVLISGKLTSE 130
            |.|||||.:|.||:|:|:||:|||::||.|||.||.:||:.||:.|:::|||...|:..|:....
Human   125 LALLILQAVPQISTLAWYTTLVPLLVVLGVTAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKVA 189

Zfish   131 KWMNVQVGDIIKLENNQFVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLE 195
            ||..:||||:|:|:.|.||.||:||||||||.:|.|:||||||||||||.|.||.:|.......:
Human   190 KWKEIQVGDVIRLKKNDFVPADILLLSSSEPNSLCYVETAELDGETNLKFKMSLEITDQYLQRED 254

Zfish   196 ALAAFNGEVCCEPPNNRLDRFTGTLTFDTQKYSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKL 260
            .||.|:|.:.||.||||||:|||||.:....:.||.:::|||||.:||||:|.|||:|||.:||:
Human   255 TLATFDGFIECEEPNNRLDKFTGTLFWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKI 319

Zfish   261 MQNCGKSTFKRTSIDRLMNVLVLFIFALLALMCIILAVGHGIWENYTG-SKFNVFLPHEENAAFS 324
            |:|.||:.||||.||.|||.:|..||.:|.|:...||:||..||...| |.:.::...::..::.
Human   320 MKNSGKTRFKRTKIDYLMNYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYR 384

Zfish   325 AFLTFWSYIIILNTVVPISLYVSMEVIRLGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIK 389
            .||.||.|||:|||:||||||||:||||||.|::||||..||:...||||:||||||||:||||.
Human   385 GFLIFWGYIIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIH 449

Zfish   390 YIFSDKTGTLTQNIMTFNKCSINGKSYG---DVFQHYSGQTLEITEETTPVDFSFNGLADPKFLF 451
            |||||||||||||||||.||.|||:.||   |..||...:..:       ||||:|..||.|..|
Human   450 YIFSDKTGTLTQNIMTFKKCCINGQIYGDHRDASQHNHNKIEQ-------VDFSWNTYADGKLAF 507

Zfish   452 YDHSLVEAVKL-ELPEVHAFFRLLALCHTCMAEEKKEGHLVYQAQSPDEGALVTAARNFGFVFRS 515
            |||.|:|.::. :.|||..||.|||:|||.|. ::.:|.|.|||.||||||||.|||||||.|.:
Human   508 YDHYLIEQIQSGKEPEVRQFFFLLAVCHTVMV-DRTDGQLNYQAASPDEGALVNAARNFGFAFLA 571

Zfish   516 RSPETITIEEMGIQRTYELLAILDFNNVRKRMSVIVRNPEGKLSLYCKGADTIIYERLHPSCSKL 580
            |:..||||.|:|.:|||.:|||||||:.|||||:|||.|||.:.||||||||:|||||| ..:..
Human   572 RTQNTITISELGTERTYNVLAILDFNSDRKRMSIIVRTPEGNIKLYCKGADTVIYERLH-RMNPT 635

Zfish   581 MEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESSVAMEDREEKLDKVYEEIEKDMML 645
            .:.|.:.|:.||.|.||||.|.||:::|..|.||.::...:|||..:|:|.|||||||||||::|
Human   636 KQETQDALDIFANETLRTLCLCYKEIEEKEFTEWNKKFMAASVASTNRDEALDKVYEEIEKDLIL 700

Zfish   646 IGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENIGYSCNLLREEMNDVFIVAAHSPE 710
            :|||||||||||||..||..||||:||||||||||:|||||||::|.||.|:....:....:|..
Human   701 LGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLL 765

Zfish   711 EVRQELRDAR----LKMQPSTEQDKFLIPEVILGNTPKVVQDEHVNGEYGLVINGHSL-AFALES 770
            ..|.|.:..|    .|..|.. |:.|..|                .|...|:|.|..| ...||.
Human   766 HARMENQRNRGGVYAKFAPPV-QESFFPP----------------GGNRALIITGSWLNEILLEK 813

Zfish   771 S------MELEFLRT----------------------------ACMCKTVICCRVTPLQKAQVVE 801
            .      ::|:|.||                            ||.|..||||||||.|||.||:
Human   814 KTKRNKILKLKFPRTEEERRMRTQSKRRLEAKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVD 878

Zfish   802 LVKRYKKAVTLAIGDGANDVSMIKAAHIGVGISGQEGMQAVLSSDFSFAQFRFLQRLLLVHGRWS 866
            ||||||||:|||||||||||:|||.||||||||||||||||:|||:||||||:||||||||||||
Human   879 LVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWS 943

Zfish   867 YLRMCKFLRYFFYKNFTFTFVHFWYAFFCGFSAQTVYDEGFITLYNLVYTALPVLGMSLFDQDVN 931
            |:||||||||||||||.||.|||||:||.|:||||.|::.||||||::||:||||.|.|.||||:
Human   944 YIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYTSLPVLLMGLLDQDVS 1008

Zfish   932 ANWSLEFPQLYVPGQLSQYFSKRAFMMCALHSCYSSLVLFFVPYATTYDTARADGRDGADYQSFA 996
            ...||.||.||:.||....|:.:.|.:..||...:|::|||:|......|...||...:||||||
Human  1009 DKLSLRFPGLYIVGQRDLLFNYKRFFVSLLHGVLTSMILFFIPLGAYLQTVGQDGEAPSDYQSFA 1073

Zfish   997 LITQTCLTVTVCVQLGLDLSYWTVVNHLFVWGSLGMFFFLTFTMYTDGLFKLRPASFAFIGTARN 1061
            :...:.|.:||..|:|||.||||.||...::||:.::|.:.|..::.|:..|.|::|.|.|||.|
Human  1074 VTIASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASN 1138

Zfish  1062 CLNQPNVWLTVALTALLCVLPVVAYRFIYCQIYPTINDKVRYKMRQMK-EPAPRPRPRLTRR--S 1123
            .|.||.:|||:.|...:|:|||||.||:...|:|:.:||::...:::| |...:.|.::.||  |
Human  1139 ALRQPYIWLTIILAVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWQRRQQVFRRGVS 1203

Zfish  1124 TRRSGYAFSHAQGYGDLVTSRRFLRR---PAPARSAGFTPAGRSPG 1166
            ||||.|||||.:||.||::|.|.:|:   |..|..|..|...|..|
Human  1204 TRRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIVADGTAEYRRTG 1249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	551/981 (56%)
ATP8B1	NP_001361314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	551/982 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D39163at33208
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830