DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atp8b5a and ATP8A2

DIOPT Version :9

Sequence 1:	XP_021332106.1	Gene:	atp8b5a / 100330945	ZFINID:	ZDB-GENE-060531-48	Length:	1205	Species:	Danio rerio
Sequence 2:	NP_057613.4	Gene:	ATP8A2 / 51761	HGNCID:	13533	Length:	1188	Species:	Homo sapiens

Alignment Length:	1159	Identity:	483/1159 - (41%)
Similarity:	699/1159 - (60%)	Gaps:	90/1159 - (7%)

- Green bases have known domain annotations that are detailed below.

Zfish    18 RKIRANDREYNSSFKYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYFLFLLILQVIPAISSLSW 82
            |.|..|....|   |:..|.|.|:||:..:|||..|:||.:|.|||:|||:.:||.||.:|....
Human    56 RTIYLNQPHLN---KFRDNQISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGR 117

Zfish    83 FTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKVNVLISGKLTSEKWMNVQVGDIIKLENNQ 147
            :||:|||:::|::...|:.::|..||::|..||.:|..||.:|...:..|..|.||||:|:.|.|
Human   118 YTTLVPLIIILTIAGIKEIVEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVVNGQ 182

Zfish   148 FVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLEALAAFNGEVCCEPPNNR 212
            ::.||::|||||||..:.|:|||.||||||||::|.|:.|.|| ...|.|...:|.:.||.||..
Human   183 YLPADVVLLSSSEPQAMCYVETANLDGETNLKIRQGLSHTADM-QTREVLMKLSGTIECEGPNRH 246

Zfish   213 LDRFTGTLTFDTQK-YSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKLMQNCGKSTFKRTSIDR 276
            |..|||.|..|.:. .:|..:::||||..||||.|.||:|::.|.:||||||..|:..||:::::
Human   247 LYDFTGNLNLDGKSLVALGPDQILLRGTQLRNTQWVFGIVVYTGHDTKLMQNSTKAPLKRSNVEK 311

Zfish   277 LMNVLVLFIFALLALMCIILAVGHGIWENYTGSKFNVFLPHEENAAFSAFLTFWSYIIILNTVVP 341
            :.||.:|.:|.:|.:|.::.:.|...|....|.| |.::...:..:.:......::||:.|.::|
Human   312 VTNVQILVLFGILLVMALVSSAGALYWNRSHGEK-NWYIKKMDTTSDNFGYNLLTFIILYNNLIP 375

Zfish   342 ISLYVSMEVIRLGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIKYIFSDKTGTLTQNIMTF 406
            |||.|::||::...:.:||||.:||:...||||.|||:.|||||||:||:|||||||||.|||.|
Human   376 ISLLVTLEVVKYTQALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNF 440

Zfish   407 NKCSINGKSYGDVFQHYSGQTLEITEETTPVDF-----------SFNGLADPKFLFYDHSLVEAV 460
            .||||.|.:||    |:.    |:..|.:..||           .|:   ||:.|    ..:|..
Human   441 KKCSIAGVTYG----HFP----ELAREPSSDDFCRMPPPCSDSCDFD---DPRLL----KNIEDR 490

Zfish   461 KLELPEVHAFFRLLALCHTCMAEEKKEG-HLVYQAQSPDEGALVTAARNFGFVFRSRSPETITIE 524
            ....|.:..|..|||:|||.:.|  |:| :::|||.||||.|||..|:..||||.:|:|.::.||
Human   491 HPTAPCIQEFLTLLAVCHTVVPE--KDGDNIIYQASSPDEAALVKGAKKLGFVFTARTPFSVIIE 553

Zfish   525 EMGIQRTYELLAILDFNNVRKRMSVIVRNPEGKLSLYCKGADTIIYERLHPSCSKLMEVTTEHLN 589
            .||.::|:.:|.:|:|::.|||||||||.|.|:|.|||||||.:|:|||... ||.||.|..||.
Human   554 AMGQEQTFGILNVLEFSSDRKRMSVIVRTPSGRLRLYCKGADNVIFERLSKD-SKYMEETLCHLE 617

Zfish   590 EFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESSVAMEDREEKLDKVYEEIEKDMMLIGATAIEDK 654
            .||.||||||.:||.||.|:.:.||.:.:.|:|..::||.::|::.||.|||:::|:|||||||:
Human   618 YFATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYEIIEKNLLLLGATAIEDR 682

Zfish   655 LQDGVALTIELLAKAEIKIWVLTGDKQETAENIGYSCNLLREEMNDVFIVAAHSPEEVRQELRDA 719
            ||.||..||..|.|||||||||||||||||.||||||.|:.:.| .:.::...|.:..|..:
Human   683 LQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNM-ALILLKEDSLDATRAAI--- 743

Zfish   720 RLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVNGEYGLVINGHSLAFALESSMELEFLRTACMCK 784
               .|..|:          |||   ::..|:   :..|:|:||:|.:||...:...||..|..||
Human   744 ---TQHCTD----------LGN---LLGKEN---DVALIIDGHTLKYALSFEVRRSFLDLALSCK 789

Zfish   785 TVICCRVTPLQKAQVVELVKRYKKAVTLAIGDGANDVSMIKAAHIGVGISGQEGMQAVLSSDFSF 849
            .||||||:||||:::|::||:..||:|||||||||||.||:.||:||||||.|||||..:||::.
Human   790 AVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAI 854

Zfish   850 AQFRFLQRLLLVHGRWSYLRMCKFLRYFFYKNFTFTFVHFWYAFFCGFSAQTVYDEGFITLYNLV 914
            |||.:|::||||||.|||.|:.|.:.|.||||.....:..|:||..|||.|.:::...|.|||::
Human   855 AQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVI 919

Zfish   915 YTALPVLGMSLFDQDVNANWSLEFPQLYVPGQLSQYFSKRAFMMCALHSCYSSLVLFFVPY-ATT 978
            :||||...:.:|::.......|.|||||...|..:.|:.:.|....:::...||:||:.|. |..
Human   920 FTALPPFTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVFWGHCINALVHSLILFWFPMKALE 984

Zfish   979 YDTARADGRDGADYQSFALITQTCLTVTVCVQLGLDLSYWTVVNHLFVWGSLGMFFFLTFTMYTD 1043
            :||....|. ..||.....|..|.:.||||::.||:.:.||..:||.||||: :.:.:.|.:|:.
Human   985 HDTVLTSGH-ATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSM-LTWLVFFGIYST 1047

Zfish  1044 GLFKLRPASFAFIGTARNCLNQPNVWLTVALTALLCVLPVVAYRFIYCQIYPTINDKVR---YKM 1105
             ::...|.:....|.|...|:..:.||.:.|....|::..||:|........|:.::|:   .|.
Human  1048 -IWPTIPIAPDMRGQATMVLSSAHFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKS 1111

Zfish  1106 RQMKEPAPR--------PRPRLTRRSTRRS----------------GYAFSHAQ 1135
            |.:.:...|        .|.||.:|..|::                |||||..:
Human  1112 RVLGKAVLRDSNGKRLNERDRLIKRLGRKTPPTLFRGSSLQQGVPHGYAFSQEE 1165

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	427/950 (45%)
ATP8A2	NP_057613.4	ATPase-Plipid	68..1106	CDD:273734	465/1083 (43%)
ATP8A2	NP_057613.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1162..1188		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830