DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment atp8b5a and ATP8A1

DIOPT Version :9

Sequence 1:	XP_021332106.1	Gene:	atp8b5a / 100330945	ZFINID:	ZDB-GENE-060531-48	Length:	1205	Species:	Danio rerio
Sequence 2:	XP_011511917.1	Gene:	ATP8A1 / 10396	HGNCID:	13531	Length:	1171	Species:	Homo sapiens

Alignment Length:	1190	Identity:	471/1190 - (39%)
Similarity:	704/1190 - (59%)	Gaps:	102/1190 - (8%)

- Green bases have known domain annotations that are detailed below.

Zfish    11 KKEKEVERKIRANDREYNSSF-------KYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYFLFL 68
            |.:...|:...|:..|..:.|       |:..|.:.|:|||..:|||..|:.||:|.||::|||:
Human    20 KTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFI 84

Zfish    69 LILQVIPAISSLSWFTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKVNVLISGKLTSEKWM 133
            .:||.||.:|....:||:|||:.:|:|.|.|:.|:||.||::|..||.::..||.:|......|.
Human    85 ALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWE 149

Zfish   134 NVQVGDIIKLENNQFVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLEALA 198
            .|.||||:.::..:::.||.:|||||||..:.||||:.||||||||::|.|..|.|: .::::|.
Human   150 KVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDI-KDVDSLM 213

Zfish   199 AFNGEVCCEPPNNRLDRFTGTLTFDTQ-KYSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKLMQ 262
            ..:|.:.||.||..|..|.|.:..|.. ...|..:::||||..||||.|..|:|::.|.:|||||
Human   214 RISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQ 278

Zfish   263 NCGKSTFKRTSIDRLMNVLVLFIFALLALMCIILAVGHGIW-ENYTGSKFNVFLPHEENAAFSAF 326
            |......|.::::|:.||.:|.:|.:|..|.::.:||..|| ..::|..:.:.|.:...:.|.
Human   279 NSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFG-- 341

Zfish   327 LTFWSYIIILNTVVPISLYVSMEVIRLGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIKYI 391
            |.|.::||:.|.::||||.|::||::...:|:||||.:|::..|||.|.|||:.|||||||:|||
Human   342 LNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYI 406

Zfish   392 FSDKTGTLTQNIMTFNKCSINGKSYGDVFQHYSGQTLEITEE--TTPVDFSFNGLADPKFLFYDH 454
            |||||||||.|:|.|.||:|.|.:||.|.:         .|:  .:|.::..:...|.| .|.|.
Human   407 FSDKTGTLTCNVMQFKKCTIAGVAYGHVPE---------PEDYGCSPDEWQNSQFGDEK-TFSDS 461

Zfish   455 SLVEAVKLE---LPEVHAFFRLLALCHTCMAEEKKEG-HLVYQAQSPDEGALVTAARNFGFVFRS 515
            ||:|.::..   .|.:..|..::|:|||.:.|  :|| .::|||.||||||||.||:...|||..
Human   462 SLLENLQNNHPTAPIICEFLTMMAVCHTAVPE--REGDKIIYQAASPDEGALVRAAKQLNFVFTG 524

Zfish   516 RSPETITIEEMGIQRTYELLAILDFNNVRKRMSVIVRNPEGKLSLYCKGADTIIYERLHPSCSKL 580
            |:|:::.|:.:|.:..||||.:|:|.:.|||||||||.|.|||.||||||||:||:|| ...||.
Human   525 RTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRL-AETSKY 588

Zfish   581 MEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESSVAMEDREEKLDKVYEEIEKDMML 645
            .|:|.:||.:||.||||||..|..::.|..|.||:..:..:|.::::|..||::.||.|||::.|
Human   589 KEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQL 653

Zfish   646 IGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENIGYSCNLLREEMNDVFI------V 704
            :|||||||||||.|..|||.|.||:||||:|||||||||.|||:||.||::.|..:.|      |
Human   654 LGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDV 718

Zfish   705 AAHSPEEVRQELR-------DARLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVNGEYGLVINGH 762
            ...:.|..|:.|.       ||..|                             ..::.|:|:|.
Human   719 EDRAVEGTRETLSRHCTTLGDALRK-----------------------------ENDFALIIDGK 754

Zfish   763 SLAFALESSMELEFLRTACMCKTVICCRVTPLQKAQVVELVKRYKKAVTLAIGDGANDVSMIKAA 827
            :|.:||...:...||..|..||.||||||:||||::|||:||:..|.|||||||||||||||:.|
Human   755 TLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTA 819

Zfish   828 HIGVGISGQEGMQAVLSSDFSFAQFRFLQRLLLVHGRWSYLRMCKFLRYFFYKNFTFTFVHFWYA 892
            |:||||||.||:||..|||:|.|||::|:.||::||.|:|.|:.|.:.|.||||.....:..|:|
Human   820 HVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFA 884

Zfish   893 FFCGFSAQTVYDEGFITLYNLVYTALPVLGMSLFDQDVNANWSLEFPQLYVPGQLSQYFSKRAFM 957
            |..|||.|.:::...|.|||:::||:|.|.:.:|::.......|::|:||...|.:..|:.:.|.
Human   885 FVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFW 949

Zfish   958 MCALHSCYSSLVLFFVPY-ATTYDTARADGRDGADYQSFALITQTCLTVTVCVQLGLDLSYWTVV 1021
            :..|:..:.|::||:.|. |..|.||..:|:. :||........|.:.:|||::.||:.||||..
Human   950 VHCLNGLFHSVILFWFPLKALQYGTAFGNGKT-SDYLLLGNFVYTFVVITVCLKAGLETSYWTWF 1013

Zfish  1022 NHLFVWGSLGMFFFLTFTMYTDGLFKLRPASFAFIGTARNCLNQPNVWLTVALTALLCVLPVVAY 1086
            :|:.:|||:.: :.:.|.:|: .|:...|.:....|.|....:....|:.:....:..:|..|.|
Human  1014 SHIAIWGSIAL-WVVFFGIYS-SLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVY 1076

Zfish  1087 RFIYCQIYPTINDKVRYKMRQMKEPAP-------RPRPRLTRRSTRRS----------------G 1128
            :.|....:.|:.|:|:....:.::|..       ..|.:|.:...:::                |
Human  1077 KVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHG 1141

Zfish  1129 YAFSHAQGYGDLVTSRRFLR 1148
            ||||  |....:|:....:|
Human  1142 YAFS--QDENGIVSQSEVIR 1159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	418/958 (44%)
ATP8A1	XP_011511917.1	PhoLip_ATPase_N	38..100	CDD:292826	24/61 (39%)
		ATPase-Plipid	49..1093	CDD:273734	454/1091 (42%)
		E1-E2_ATPase	106..>191	CDD:278548	36/84 (43%)
		Cation_ATPase	486..581	CDD:289987	55/96 (57%)
		HAD_like	<803..853	CDD:304363	36/49 (73%)
		PhoLip_ATPase_C	834..1086	CDD:292829	81/254 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0000076
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100089
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X168
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.830