Protein Alignment atp8b5a and ATP8A1

DIOPT Version :10

• Sequence 1: XP_021332106.1
• Gene: atp8b5a / 100330945
• ZFINID: ZDB-GENE-060531-48
• Length: 1205
• Species: Danio rerio
• Sequence 2: XP_011511917.1
• Gene: ATP8A1 / 10396
• HGNCID: 13531
• Length: 1171
• Species: Homo sapiens
• Alignment Length: 1190
• Identity: 471/1190 - (39%)
• Similarity: 704/1190 - (59%)
• Gaps: 102/1190 - (8%)

Zfish    11 KKEKEVERKIRANDREYNSSF-------KYATNCIKTSKYNPFSFLPLNLFEQFQRIANAYFLFL 68
            |.:...|:...|:..|..:.|       |:..|.:.|:|||..:|||..|:.||:|.||::|||:
Human    20 KTDDVSEKTSLADQEEVRTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFI 84

Zfish    69 LILQVIPAISSLSWFTTVVPLVLVLSVTAAKDAIDDINRHRSDRQVNNRKVNVLISGKLTSEKWM 133
            .:||.||.:|....:||:|||:.:|:|.|.|:.|:||.||::|..||.::..||.:|......|.
Human    85 ALLQQIPDVSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRNGAWEIVHWE 149

Zfish   134 NVQVGDIIKLENNQFVTADLLLLSSSEPLNLVYIETAELDGETNLKVKQSLTVTGDMGHNLEALA 198
            .|.||||:.::..:::.||.:|||||||..:.||||:.||||||||::|.|..|.|: .::::|.
Human   150 KVNVGDIVIIKGKEYIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDI-KDVDSLM 213

Zfish   199 AFNGEVCCEPPNNRLDRFTGTLTFDTQ-KYSLDNERVLLRGCTLRNTDWCFGLVLFAGPETKLMQ 262
            ..:|.:.||.||..|..|.|.:..|.. ...|..:::||||..||||.|..|:|::.|.:|||||
Human   214 RISGRIECESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQ 278

Zfish   263 NCGKSTFKRTSIDRLMNVLVLFIFALLALMCIILAVGHGIW-ENYTGSKFNVFLPHEENAAFSAF 326
            |......|.::::|:.||.:|.:|.:|..|.::.:||..|| ..::|..:.:.|.:...:.|.
Human   279 NSTSPPLKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFG-- 341

Zfish   327 LTFWSYIIILNTVVPISLYVSMEVIRLGNSYYINWDRNMYHTRTDTPAEARTTTLNEELGQIKYI 391
            |.|.::||:.|.::||||.|::||::...:|:||||.:|::..|||.|.|||:.|||||||:|||
Human   342 LNFLTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYI 406

Zfish   392 FSDKTGTLTQNIMTFNKCSINGKSYGDVFQHYSGQTLEITEE--TTPVDFSFNGLADPKFLFYDH 454
            |||||||||.|:|.|.||:|.|.:||.|.:         .|:  .:|.::..:...|.| .|.|.
Human   407 FSDKTGTLTCNVMQFKKCTIAGVAYGHVPE---------PEDYGCSPDEWQNSQFGDEK-TFSDS 461

Zfish   455 SLVEAVKLE---LPEVHAFFRLLALCHTCMAEEKKEG-HLVYQAQSPDEGALVTAARNFGFVFRS 515
            ||:|.::..   .|.:..|..::|:|||.:.|  :|| .::|||.||||||||.||:...|||..
Human   462 SLLENLQNNHPTAPIICEFLTMMAVCHTAVPE--REGDKIIYQAASPDEGALVRAAKQLNFVFTG 524

Zfish   516 RSPETITIEEMGIQRTYELLAILDFNNVRKRMSVIVRNPEGKLSLYCKGADTIIYERLHPSCSKL 580
            |:|:::.|:.:|.:..||||.:|:|.:.|||||||||.|.|||.||||||||:||:|| ...||.
Human   525 RTPDSVIIDSLGQEERYELLNVLEFTSARKRMSVIVRTPSGKLRLYCKGADTVIYDRL-AETSKY 588

Zfish   581 MEVTTEHLNEFAGEGLRTLVLAYKDLDEDYFAEWKQRHHESSVAMEDREEKLDKVYEEIEKDMML 645
            .|:|.:||.:||.||||||..|..::.|..|.||:..:..:|.::::|..||::.||.|||::.|
Human   589 KEITLKHLEQFATEGLRTLCFAVAEISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQL 653

Zfish   646 IGATAIEDKLQDGVALTIELLAKAEIKIWVLTGDKQETAENIGYSCNLLREEMNDVFI------V 704
            :|||||||||||.|..|||.|.||:||||:|||||||||.|||:||.||::.|..:.|      |
Human   654 LGATAIEDKLQDQVPETIETLMKADIKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDV 718

Zfish   705 AAHSPEEVRQELR-------DARLKMQPSTEQDKFLIPEVILGNTPKVVQDEHVNGEYGLVINGH 762
            ...:.|..|:.|.       ||..|                             ..::.|:|:|.
Human   719 EDRAVEGTRETLSRHCTTLGDALRK-----------------------------ENDFALIIDGK 754

Zfish   763 SLAFALESSMELEFLRTACMCKTVICCRVTPLQKAQVVELVKRYKKAVTLAIGDGANDVSMIKAA 827
            :|.:||...:...||..|..||.||||||:||||::|||:||:..|.|||||||||||||||:.|
Human   755 TLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGDGANDVSMIQTA 819

Zfish   828 HIGVGISGQEGMQAVLSSDFSFAQFRFLQRLLLVHGRWSYLRMCKFLRYFFYKNFTFTFVHFWYA 892
            |:||||||.||:||..|||:|.|||::|:.||::||.|:|.|:.|.:.|.||||.....:..|:|
Human   820 HVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKNIVLYIIEIWFA 884

Zfish   893 FFCGFSAQTVYDEGFITLYNLVYTALPVLGMSLFDQDVNANWSLEFPQLYVPGQLSQYFSKRAFM 957
            |..|||.|.:::...|.|||:::||:|.|.:.:|::.......|::|:||...|.:..|:.:.|.
Human   885 FVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQNALDFNTKVFW 949

Zfish   958 MCALHSCYSSLVLFFVPY-ATTYDTARADGRDGADYQSFALITQTCLTVTVCVQLGLDLSYWTVV 1021
            :..|:..:.|::||:.|. |..|.||..:|:. :||........|.:.:|||::.||:.||||..
Human   950 VHCLNGLFHSVILFWFPLKALQYGTAFGNGKT-SDYLLLGNFVYTFVVITVCLKAGLETSYWTWF 1013

Zfish  1022 NHLFVWGSLGMFFFLTFTMYTDGLFKLRPASFAFIGTARNCLNQPNVWLTVALTALLCVLPVVAY 1086
            :|:.:|||:.: :.:.|.:|: .|:...|.:....|.|....:....|:.:....:..:|..|.|
Human  1014 SHIAIWGSIAL-WVVFFGIYS-SLWPAIPMAPDMSGEAAMLFSSGVFWMGLLFIPVASLLLDVVY 1076

Zfish  1087 RFIYCQIYPTINDKVRYKMRQMKEPAP-------RPRPRLTRRSTRRS----------------G 1128
            :.|....:.|:.|:|:....:.::|..       ..|.:|.:...:::                |
Human  1077 KVIKRTAFKTLVDEVQELEAKSQDPGAVVLGKSLTERAQLLKNVFKKNHVNLYRSESLQQNLLHG 1141

Zfish  1129 YAFSHAQGYGDLVTSRRFLR 1148
            ||||  |....:|:....:|
Human  1142 YAFS--QDENGIVSQSEVIR 1159

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
atp8b5a	XP_021332106.1	P-type_ATPase_APLT_Dnf-like	36..974	CDD:319770	418/958 (44%)
ATP8A1	XP_011511917.1	ATPase-Plipid	49..1093	CDD:273734	454/1091 (42%)