DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH5 and Cdh5

DIOPT Version :9

Sequence 1:	XP_011521103.1	Gene:	CDH5 / 1003	HGNCID:	1764	Length:	793	Species:	Homo sapiens
Sequence 2:	XP_038953616.1	Gene:	Cdh5 / 307618	RGDID:	1307370	Length:	777	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	598/795 - (75%)
Similarity:	678/795 - (85%)	Gaps:	22/795 - (2%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLP 65
            ||||..|....|..||||||||:  ||.|        :||.|:||||||||||||||||||.|||
  Rat     1 MQRLTELATALGTFLGLLAVAAM--AGPN--------MLPVHQRQKRDWIWNQMHIDEEKNESLP 55

Human    66 HHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGEN 130
            |:||||||:|:|:||||:|:||..||:|||||:||||.|.||||||.:|||.|||:||||.|.:|
  Rat    56 HYVGKIKSNVNRQNAKYVLQGEQAGKIFRVDADTGDVLAYERLDREKVSEYFLTALIVDKKTNKN 120

Human   131 LETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK 195
            ||.|||||:||||||||||||||::|||||||.||:|||||.|||.|||||||..||:|:||::|
  Rat   121 LEQPSSFTVKVHDVNDNWPVFTHQVFNASVPEMSAIGTSVIRVTATDADDPTVAGHATVLYQMVK 185

Human   196 GKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQ 260
            |.|||||||||.|.|..|:||||.:|.|:|||||:|||||||:|||||||:.|:|||||||.|||
  Rat   186 GNEYFAIDNSGLIFTKDKNLDRETRAEYKIVVEAQDAQGLRGESGTATVLIRLEDINDNFPIFTQ 250

Human   261 TLWGALFASAKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNE 325
                     :.|||.||||.|||..:|||.||||||||||||||||::|:|:|.|||||:|..||
  Rat   251 ---------STYTFSVPEDIRVGKPLGSLSVEDPDEPQNRMTKYSIMQGEYRDTFTIETDPDRNE 306

Human   326 GIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAG-NRAQVIINITDVDEPPIFQQPFYHFQ 389
            |||||.||||||.||||:|.:|||||||.|.|:|..|| |:|::|||:.||||||:||:.||||.
  Rat   307 GIIKPTKPLDYELIQQYTFHIEATDPTIRLGYLSSTAGKNKAKIIINVLDVDEPPVFQRRFYHFH 371

Human   390 LKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTV 454
            |.||:||||||||:|.|||.|:.|||||||:|||:||:||:||:|:||||||||||.:.||||||
  Rat   372 LPENKKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQYFRITKQGNIYNEKELDRETHAWYNLTV 436

Human   455 EAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPR 519
            ||.||||.|.|.|||||||::||||||||||||||:||:|||||||..|:||:||||.|||:.|.
  Rat   437 EANELDSRGNPVGKESIVQIYIEVLDENDNAPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPV 501

Human   520 NVKFKFIL-NTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVA 583
            |.||||.| |.::||||.:|||||||||||||||:|||||.|:|||:||||||||.|||.|||||
  Rat   502 NTKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHTKFHYLPVLISDNGMPSLTGTGTLTVA 566

Human   584 VCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTIT-VITLLIFLRRRLRKQARAHGKSVPEI 647
            ||||||||||||||:||||.||||||:|||.||||||| ||||||||||||||||.||.||..||
  Rat   567 VCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITAVITLLIFLRRRLRKQAHAHSKSALEI 631

Human   648 HEQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPG 712
            |||||||||||||||||||||||||||||.|..||.|..:||||::|.|||||||.||..||||.
  Rat   632 HEQLVTYDEEGGGEMDTTSYDVSVLNSVRTGSNKPLRSTMDARPAVYTQVQKPPRLAPSLHGGPR 696

Human   713 EMAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFK 777
            |||.||||||:|||:||.||||||||||||||:||||||||||.|:|||||:|||||||||||||
  Rat   697 EMATMIEVKKEEADNDGGGPPYDTLHIYGYEGTESIAESLSSLSTNSSDSDIDYDFLNDWGPRFK 761

Human   778 MLAELYGSDPREELL 792
            ||||||||||:|||:
  Rat   762 MLAELYGSDPQEELI 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH5	XP_011521103.1	CA	79..149	CDD:214520	52/69 (75%)
		Cadherin_repeat	156..254	CDD:206637	72/97 (74%)
		Cadherin	272..373	CDD:278457	73/101 (72%)
		Cadherin_repeat	386..484	CDD:206637	74/97 (76%)
		Cadherin_repeat	491..585	CDD:206637	71/94 (76%)
		Cadherin_C	635..786	CDD:307269	124/150 (83%)
Cdh5	XP_038953616.1	CA	69..139	CDD:214520	52/69 (75%)
		Cadherin_repeat	145..244	CDD:206637	72/98 (73%)
		Cadherin_repeat	252..359	CDD:206637	75/106 (71%)
		Cadherin_repeat	368..466	CDD:206637	74/97 (76%)
		Cadherin_repeat	473..568	CDD:206637	71/94 (76%)
		Cadherin_C	619..770	CDD:395833	124/150 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83696404
Domainoid	1	1.000	262	1.000	Domainoid score	I18029
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1359
Inparanoid	1	1.050	1211	1.000	Inparanoid score	I4022
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40485
OrthoDB	1	1.010	-	-		D108312at7742
OrthoFinder	1	1.000	-	-		FOG0000109
OrthoInspector	1	1.000	-	-		oto138301
orthoMCL	1	0.900	-	-		OOG6_120398
Panther	1	1.100	-	-	LDO	PTHR24027
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X10986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.410