DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH5 and Cdh5

DIOPT Version :9

Sequence 1:	XP_011521103.1	Gene:	CDH5 / 1003	HGNCID:	1764	Length:	793	Species:	Homo sapiens
Sequence 2:	NP_033998.2	Gene:	Cdh5 / 12562	MGIID:	105057	Length:	784	Species:	Mus musculus

Alignment Length:	794	Identity:	592/794 - (74%)
Similarity:	675/794 - (85%)	Gaps:	13/794 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     1 MQRLMMLLATSGACLGLLAVAAVAAAGANPAQRDTHSLLPTHRRQKRDWIWNQMHIDEEKNTSLP 65
            ||||..|....||.||||||||:  ||.|..|.||.::||.|.||||||||||||||||||.|||
Mouse     1 MQRLTELATALGAFLGLLAVAAM--AGPNFPQIDTPNMLPAHHRQKRDWIWNQMHIDEEKNESLP 63

Human    66 HHVGKIKSSVSRKNAKYLLKGEYVGKVFRVDAETGDVFAIERLDRENISEYHLTAVIVDKDTGEN 130
            |:||||||:|:|:||||:|:||:.||:|.|||.||:|.|.||||||.:|||.|||:||||:|.:|
Mouse    64 HYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKN 128

Human   131 LETPSSFTIKVHDVNDNWPVFTHRLFNASVPESSAVGTSVISVTAVDADDPTVGDHASVMYQILK 195
            ||.|||||:||||:|||||||:|::|||||||.||:|||||.|||||||||||..||:|:|||:|
Mouse   129 LEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVK 193

Human   196 GKEYFAIDNSGRIITITKSLDREKQARYEIVVEARDAQGLRGDSGTATVLVTLQDINDNFPFFTQ 260
            |.|||:|||||.|.|..|:|||||||.|:||||.:||.||||:||||||::.|:|||||||.|||
Mouse   194 GNEYFSIDNSGLIFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQ 258

Human   261 TLWGALFASAKYTFVVPEDTRVGTSVGSLFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNE 325
                     :.|||.||||.|||..:|.|.|.||||||||||||||::|:|:|.|||||:|..||
Mouse   259 ---------STYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPKRNE 314

Human   326 GIIKPMKPLDYEYIQQYSFIVEATDPTIDLRYMSPPAG-NRAQVIINITDVDEPPIFQQPFYHFQ 389
            |||||.|.||||.||||:|.:|||||||...|:|..:| |:|.|.||:.||||||:||:.||||:
Mouse   315 GIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGKNKAMVTINVLDVDEPPVFQRHFYHFK 379

Human   390 LKENQKKPLIGTVLAMDPDAARHSIGYSIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTV 454
            |.|||||||||||:|.|||.|:.|||||||:|||:|||||:||:|:||||||||||.|.||||||
Mouse   380 LPENQKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTV 444

Human   455 EAKELDSTGTPTGKESIVQVHIEVLDENDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPR 519
            ||.||||.|.|.||||||||:|||||||||.||||:||:|||||||..|:||:||||.|||:.|.
Mouse   445 EANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPV 509

Human   520 NVKFKFIL-NTENNFTLTDNHDNTANITVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVA 583
            |.||||.| |.::||||.:|||||||||||||||:|||.|.|:|||:|||||:||.||||||||.
Mouse   510 NPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVG 574

Human   584 VCKCNEQGEFTFCEDMAAQVGVSIQAVVAILLCILTITVITLLIFLRRRLRKQARAHGKSVPEIH 648
            ||||||||||||||:||||.||||||:|||.|||||||||||||.||||:||||.||.||..|||
Mouse   575 VCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRIRKQAHAHSKSALEIH 639

Human   649 EQLVTYDEEGGGEMDTTSYDVSVLNSVRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGE 713
            ||||||||||||||||||||||||||||.|..||.|..:||||::|.|||||||.|||.||||.|
Mouse   640 EQLVTYDEEGGGEMDTTSYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQKPPRLAPGLHGGPRE 704

Human   714 MAAMIEVKKDEADHDGDGPPYDTLHIYGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKM 778
            ||.||:|||:|||:||.||||||||||||||:||||||||||.|:|||||:||||||||||||||
Mouse   705 MATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKM 769

Human   779 LAELYGSDPREELL 792
            |||||||||:|||:
Mouse   770 LAELYGSDPQEELI 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH5	XP_011521103.1	CA	79..149	CDD:214520	49/69 (71%)
		Cadherin_repeat	156..254	CDD:206637	72/97 (74%)
		Cadherin	272..373	CDD:278457	68/101 (67%)
		Cadherin_repeat	386..484	CDD:206637	78/97 (80%)
		Cadherin_repeat	491..585	CDD:206637	69/94 (73%)
		Cadherin_C	635..786	CDD:307269	124/150 (83%)
Cdh5	NP_033998.2	CA	77..147	CDD:214520	49/69 (71%)
		Cadherin_repeat	153..252	CDD:206637	72/98 (73%)
		Cadherin_repeat	260..367	CDD:206637	70/106 (66%)
		Cadherin_repeat	376..474	CDD:206637	78/97 (80%)
		Cadherin_repeat	481..576	CDD:206637	69/94 (73%)
		Required for interaction with PALS1. /evidence=ECO:0000269\|PubMed:27466317	621..660		33/38 (87%)
		Cadherin_C	626..777	CDD:366437	124/150 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83973143
Domainoid	1	1.000	263	1.000	Domainoid score	I18811
eggNOG	1	0.900	-	-		E33208_3BBKE
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1359
Inparanoid	1	1.050	1208	1.000	Inparanoid score	I4325
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40485
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000109
OrthoInspector	1	1.000	-	-		oto122086
orthoMCL	1	0.900	-	-		OOG6_120398
Panther	1	1.100	-	-	LDO	PTHR24027
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11735
SonicParanoid	1	1.000	-	-		X10986
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.290