Protein Alignment CDH5 and cdh5

DIOPT Version :10

• Sequence 1: XP_011521103.1
• Gene: CDH5 / 1003
• HGNCID: 1764
• Length: 793
• Species: Homo sapiens
• Sequence 2: XP_004913631.2
• Gene: cdh5 / 100488458
• XenbaseID: XB-GENE-480937
• Length: 772
• Species: Xenopus tropicalis
• Alignment Length: 769
• Identity: 421/769 - (54%)
• Similarity: 530/769 - (68%)
• Gaps: 32/769 - (4%)

Human    34 DTHSLLP--THRRQKRDWIWNQMHIDEEKNTSLPHHVGKIK--SSVSRKNAKYLLKGEYVGKVFR 94
            :||   |  |.||.||.||||||.|.||:|.:|||:|||::  |||..:|||:.::||....:|:
 Frog    27 ETH---PDKTTRRVKRGWIWNQMFISEERNGNLPHYVGKLQLNSSVLHQNAKFAIQGESANTIFK 88

Human    95 VDAETGDVFAIERLDRENISEYHLTAVIVDKDTGENLETPSSFTIKVHDVNDNWPVFTHRLFNAS 159
            |:.:.||::..||||||..|||||.|::|||.|.:.||.||:|.|:|.|:|||.|.||.:.||.|
 Frog    89 VNEKNGDIYCFERLDREKKSEYHLMALLVDKKTAKTLEHPSNFVIRVIDINDNAPQFTQKAFNGS 153

Human   160 VPESSAVGTSVISVTAVDADDPTVGDHASVMYQILKGKEYFAIDNSGRIITITKSLDREKQARYE 224
            |.|.|..||.|..|||||.||||:|.:|.|.|:|::|:|||.|||.|.|.|...:||||::..||
 Frog   154 VNEMSDRGTFVTKVTAVDNDDPTIGGNAEVTYKIIQGQEYFTIDNIGTIYTAVSNLDREQRDTYE 218

Human   225 IVVEARDAQGLR-GDSGTATVLVTLQDINDNFPFFTQTLWGALFASAKYTFVVPEDTRVGTSVGS 288
            :||||||:.|.. ..|.||||::.|.|||||||.||:         :::.|.|||..:||..||.
 Frog   219 VVVEARDSPGQNMYMSSTATVIINLIDINDNFPTFTE---------SQFKFDVPETLKVGGEVGR 274

Human   289 LFVEDPDEPQNRMTKYSILRGDYQDAFTIETNPAHNEGIIKPMKPLDYEYIQQYSFIVEATDPTI 353
            |.|||.||||||.||||.|:..:|:.|.:.||...||||:...||||||.::||:..:|||||.|
 Frog   275 LKVEDIDEPQNRNTKYSFLKERFQEIFAVTTNVNTNEGILILKKPLDYESVKQYNVDIEATDPLI 339

Human   354 DLRYMSPPAGNR-AQVIINITDVDEPPIFQQPFYHFQLKENQK-KPLIGTVLAMDPDAARHSIGY 416
            |||......... ..||||:.||||||:|.:|||.|::.|:.| ..:||.|.|.|||||..:|.|
 Frog   340 DLRVAKQTRPKSITNVIINVLDVDEPPVFSKPFYKFEISEDSKLNNIIGFVSAKDPDAANRNIRY 404

Human   417 SIRRTSDKGQFFRVTKKGDIYNEKELDREVYPWYNLTVEAKELDSTGTPTGKESIVQVHIEVLDE 481
            |:|...|:.  .:||..|:|.|.|.||||...|:|.||.|:|:|.:..|..|||:..|.|:|||.
 Frog   405 SMRNFKDEP--IKVTNNGNIINVKTLDRETADWHNFTVVAEEVDPSNPPIKKESLGLVFIKVLDV 467

Human   482 NDNAPEFAKPYQPKVCENAVHGQLVLQISAIDKDITPRNVKFKFI-LNTENNFTLTDNHDNTANI 545
            ||||||||:||.|:|||||.|..::..|||.|||.....:||.:. ...|||||:.|||||||.|
 Frog   468 NDNAPEFAEPYAPRVCENAAHQTVITNISATDKDEMKPKMKFTYYSAKKENNFTVQDNHDNTATI 532

Human   546 TVKYGQFDREHTKVHFLPVVISDNGMPSRTGTSTLTVAVCKCNEQGEFTFCEDMAAQVGVSIQAV 610
            .||||.|:||..|.|:||:||||||.|.::.|:|||:.||||||:|||||||:......||:..:
 Frog   533 LVKYGYFNREVAKFHYLPIVISDNGQPEQSSTNTLTITVCKCNEKGEFTFCEEAGKLAAVSVPTI 597

Human   611 VAILLCI-LTITVITLLIFLRRRLRKQARAHGKSVPEIHEQLVTYDEEGGGEMDTTSYDVSVLNS 674
            |.|.:.: |.|.|:|:|..|||..:|.....||:..|||||||||||||||||||.|||||||||
 Frog   598 VIIFVSLFLIILVVTILAVLRRMQKKNTNILGKNTAEIHEQLVTYDEEGGGEMDTNSYDVSVLNS 662

Human   675 VRRGGAKPPRPALDARPSLYAQVQKPPRHAPGAHGGPGEMAAMIEVKKDEADHDGDGPPYDTLHI 739
            ||| ..:.||..::|.|.|||.||||.|:        |:|:.||||||||||:||:|.|||||||
 Frog   663 VRR-NVQRPRQEMEASPYLYAHVQKPTRN--------GDMSFMIEVKKDEADNDGEGLPYDTLHI 718

Human   740 YGYEGSESIAESLSSLGTDSSDSDVDYDFLNDWGPRFKMLAELYGSDPREELLY 793
            :|||.||||.|||||:.:.||:||:|||.||:|||||||||:|||.:|.|:..|
 Frog   719 FGYEESESIVESLSSIESGSSESDIDYDVLNNWGPRFKMLADLYGLEPIEDFPY 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CDH5	XP_011521103.1	CA	79..149	CDD:214520	36/69 (52%)
		Cadherin_repeat	156..254	CDD:206637	55/98 (56%)
		Cadherin	272..373	CDD:394985	52/101 (51%)
		Cadherin_repeat	386..484	CDD:206637	45/98 (46%)
		Cadherin_repeat	491..585	CDD:206637	52/94 (55%)
		CADH_Y-type_LIR	725..784	CDD:460041	43/58 (74%)
cdh5	XP_004913631.2	CA	73..143	CDD:214520	36/69 (52%)
		Cadherin_repeat	150..249	CDD:206637	55/98 (56%)
		Cadherin_repeat	257..364	CDD:206637	54/106 (51%)
		Cadherin_repeat	373..470	CDD:206637	45/98 (46%)
		Cadherin_repeat	477..572	CDD:206637	52/94 (55%)
		CADH_Y-type_LIR	704..763	CDD:460041	43/58 (74%)