DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUX4 and hbn

DIOPT Version :10

Sequence 1:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens
Sequence 2:NP_788420.1 Gene:hbn / 47894 FlyBaseID:FBgn0008636 Length:409 Species:Drosophila melanogaster


Alignment Length:406 Identity:96/406 - (23%)
Similarity:135/406 - (33%) Gaps:165/406 - (40%)


- Green bases have known domain annotations that are detailed below.


Human    68 QNERSRQLR-QHRRESRPWPGRRG------------------------PPEGRRKRTAVTGSQTA 107
            |.::.:||: |.:||..|.....|                        |.:.||.||..|..|..
  Fly   102 QQQQQQQLQVQAKREDSPTNTDGGLDVDNDDELSSSLNNGHDLSDMERPRKVRRSRTTFTTFQLH 166

Human   108 LLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRARHPGQGGRAPAQAGGLCSAAPGGGH 172
            .|.|||||.::|.:..||:||....|.|:|:|:|||||||:                        
  Fly   167 QLERAFEKTQYPDVFTREDLAMRLDLSEARVQVWFQNRRAK------------------------ 207

Human   173 PAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQAARAAPALQPSQAAPAEGISQPAPARG 237
                         |               ..:..|::|  ..|..|.|.|..|            
  Fly   208 -------------W---------------RKREKFMNQ--DKAGYLLPEQGLP------------ 230

Human   238 DFAYAAPAPPDGALSHP---QAPRWPPHPGKSREDRDPQRDGLPGPCAVAQP-GPAQAGPQG--- 295
            :|....|.||.|...||   |:..||||                  .|:.|. .||.|...|   
  Fly   231 EFPLGIPLPPHGLPGHPGSMQSEFWPPH------------------FALHQHFNPAAAAAAGLLP 277

Human   296 QGVLAP----PTSQG--SPWWG-------WGRGPQVAGAAWE---PQ-----AGAAPPPQPAPPD 339
            |.::||    |....  |.:.|       :|.|...|.||..   ||     ||.:...|.:||.
  Fly   278 QHLMAPHYKLPNFHTLLSQYMGLSNLNGIFGAGAAAAAAAASAGYPQNLSLHAGLSAMSQVSPPC 342

Human   340 ASASARQGQMQGIPAPSQALQEPAPWSALP-------CGLLLDELLASPEFLQQAQPLLETEAPG 397
            :::|.|:.        .:.:..|.|..|.|       .|||...|::             |.|..
  Fly   343 SNSSPRES--------PKLVPHPTPPHATPPAGGNGGGGLLTGGLIS-------------TAAQS 386

Human   398 ELEASEEAASLEAPLS 413
            ...|:..:::...|:|
  Fly   387 PNSAAGASSNASTPVS 402

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039 3/10 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 12/54 (22%)
Homeodomain 95..149 CDD:459649 28/53 (53%)
PRK07764 <141..319 CDD:236090 41/197 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 42/171 (25%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 20/94 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 5/26 (19%)
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424 2/9 (22%)
hbnNP_788420.1 Homeodomain 154..210 CDD:459649 29/107 (27%)
Blue background indicates that the domain is not in the aligned region.

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