Protein Alignment DUX4 and gsb-n

DIOPT Version :10

• Sequence 1: NP_001280727.1
• Gene: DUX4 / 100288687
• HGNCID: 50800
• Length: 424
• Species: Homo sapiens
• Sequence 2: NP_523862.1
• Gene: gsb-n / 38004
• FlyBaseID: FBgn0001147
• Length: 449
• Species: Drosophila melanogaster
• Alignment Length: 328
• Identity: 88/328 - (26%)
• Similarity: 116/328 - (35%)
• Gaps: 91/328 - (27%)

Human    81 ESRPW-PGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQN 144
            ||.|. |.:|   :.||.||..|..|...|.|||.:.::|.:..|||||:.|.|.|:|||:||.|
  Fly   171 ESEPGIPLKR---KQRRSRTTFTAEQLEALERAFSRTQYPDVYTREELAQTTALTEARIQVWFSN 232

Human   145 RRAR---HPG--QGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQ 204
            ||||   |.|  ..|.:|..:|.                  ::.|. |.||.....|...|.|..
  Fly   233 RRARLRKHSGGSNSGLSPMNSGS------------------SNVGV-GVGLSGATAPLGYGPLGV 278

Human   205 GAFVSQAARAAPALQPSQAAPAEGISQPAPARGDFAYAAPAPPDGALSHPQAPRWPPHPGKSRED 269
            |:....:  .||....:.|...:|:...|.|......||.|   .|.:|       .|......|
  Fly   279 GSMAGYS--PAPGTTATGAGMNDGVHHAAHAPSSHHSAATA---AAAAH-------HHTQMGGYD 331

Human   270 --RDPQRDGLPGPCAVAQPGPAQAGPQG--------------QGVLAPPTSQGSPWW-------- 310
              :...:.|.||  ..||||  ..|.|.              ..:.|...|:.||..
  Fly   332 LVQSAAQHGFPG--GFAQPG--HFGSQNYYHQDYSKLTIDDFSKLTADSVSKISPSLHLSDNYSK 392

Human   311 -----GWGRGPQVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEPAP------ 364
                 .|.:....|.|.:.     |...|....|.:|:|..|.      |:.|...|.|
  Fly   393 LEAPSNWSQAAYHAAANYN-----AHVAQHQLNDYAAAAAHGN------PASAYSHPLPTQGQAK 446

Human   365 -WS 366
             ||
  Fly   447 YWS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DUX4	NP_001280727.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..24
		homeodomain	25..78	CDD:238039
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..102		9/21 (43%)
		Homeodomain	95..149	CDD:459649	29/56 (52%)
		PRK07764	<141..319	CDD:236090	47/211 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	218..362		35/172 (20%)
		Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377	327..424		12/47 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	388..414
		Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456	405..424
gsb-n	NP_523862.1	HTH_CRP	20..141	CDD:481199
		Homeodomain	183..239	CDD:459649	29/55 (53%)