DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUX4 and prd

DIOPT Version :10

Sequence 1:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens
Sequence 2:NP_723721.1 Gene:prd / 34629 FlyBaseID:FBgn0003145 Length:613 Species:Drosophila melanogaster


Alignment Length:387 Identity:102/387 - (26%)
Similarity:134/387 - (34%) Gaps:109/387 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    86 PGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-- 148
            ||.....:.||.||..:.||...|.||||:.::|.|..|||||:.|.|.|:|||:||.|||||  
  Fly   205 PGIALKRKQRRCRTTFSASQLDELERAFERTQYPDIYTREELAQRTNLTEARIQVWFSNRRARLR 269

Human   149 --HPGQGGRAPAQAGGLCSAAPGGGHPAPSWVAFAHTGAWGTGLPAPHVPCAPGALPQGAFVSQA 211
              |....|           .||||...:.|.||                  |..:||  :.||..
  Fly   270 KQHTSVSG-----------GAPGGAAASVSHVA------------------ASSSLP--SVVSSV 303

Human   212 ARAAP-ALQPSQAAPAEGISQPAPARGDFA---YAAPAPPDGALSHPQAPRWPPH---------- 262
            ...|| |:.|....||....|.....|..|   .:|.||...:...|.....|||          
  Fly   304 PSMAPLAMMPGSLDPATVYQQQYDFYGSHANISVSAAAPMASSNLSPGITTTPPHHHQFYNPSAN 368

Human   263 ------PGKSR----------EDRDPQRDGLPG-PCAVAQPGPAQAGPQ-------GQGVLAPPT 303
                  ||::.          ...:.|...:.| .....|..|....|.       ||   .|||
  Fly   369 TASYIMPGENGNTTPTGNIIVSSYETQLGSVYGTETETHQTMPRNESPNESVSSAFGQ---LPPT 430

Human   304 SQGSPWWGWGRGPQVAGAAWEPQAGAAPPPQPAPPDASAS-------------------ARQGQM 349
            ..       .....|:||.....:||.....|:...|:||                   |.|.|:
  Fly   431 PN-------SLSAVVSGAGVTSSSGANSGADPSQSLANASAGSEELSAALKVESVDLIAASQSQL 488

Human   350 QGIPAPSQALQEPAPWSALPCGLLLDELLASPEFLQQAQPLLETEAPGELEASEEAASLEAP 411
            .|..:..|||:..||.|.       ::.|.|.....||..:...:.....:.:.:.||..||
  Fly   489 YGGWSSMQALRPNAPLSP-------EDSLNSTSSTSQALDVTAHQMFHPYQHTPQYASYPAP 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102 6/15 (40%)
Homeodomain 95..149 CDD:459649 31/57 (54%)
PRK07764 <141..319 CDD:236090 49/219 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 41/199 (21%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 24/104 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 4/24 (17%)
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424 4/7 (57%)
prdNP_723721.1 PAX 27..154 CDD:238076
Homeodomain 214..270 CDD:459649 31/55 (56%)
Blue background indicates that the domain is not in the aligned region.

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