DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUX4 and Pph13

DIOPT Version :10

Sequence 1:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens
Sequence 2:NP_477330.1 Gene:Pph13 / 33239 FlyBaseID:FBgn0023489 Length:357 Species:Drosophila melanogaster


Alignment Length:26 Identity:7/26 - (26%)
Similarity:12/26 - (46%) Gaps:0/26 - (0%)


- Green bases have known domain annotations that are detailed below.


Human   344 GRAVVEGLWLRYKGMPVEEDVGRERR 369
            |..:|...:.||.|:.....:.||.:
  Fly   117 GENIVWNTYKRYWGLAYSRMMIRETK 142

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102
Homeodomain 95..149 CDD:459649
PRK07764 <141..319 CDD:236090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362 5/17 (29%)
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 7/26 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424
Pph13NP_477330.1 Homeodomain 11..67 CDD:459649
Blue background indicates that the domain is not in the aligned region.

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