DRSC/TRiP Functional Genomics Resources

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Protein Alignment DUX4 and CG32532

DIOPT Version :10

Sequence 1:NP_001280727.1 Gene:DUX4 / 100288687 HGNCID:50800 Length:424 Species:Homo sapiens
Sequence 2:NP_608318.5 Gene:CG32532 / 32943 FlyBaseID:FBgn0052532 Length:688 Species:Drosophila melanogaster


Alignment Length:18 Identity:6/18 - (33%)
Similarity:11/18 - (61%) Gaps:0/18 - (0%)


- Green bases have known domain annotations that are detailed below.


Human   397 SVIGGLAACFIFIFPGLC 414
            :::..|.:|.|.|..|:|
  Fly     4 NLLNQLESCKICILRGVC 21

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DUX4NP_001280727.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..24
homeodomain 25..78 CDD:238039
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 72..102
Homeodomain 95..149 CDD:459649
PRK07764 <141..319 CDD:236090
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 218..362
Required for interaction with EP300 and CREBBP, and for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:26951377 327..424 6/18 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 388..414 5/16 (31%)
Important for transcriptional activation of target genes. /evidence=ECO:0000269|PubMed:29618456 405..424 5/10 (50%)
CG32532NP_608318.5 Homeodomain 511..567 CDD:459649
Blue background indicates that the domain is not in the aligned region.

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