DRSC/TRiP Functional Genomics Resources

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Protein Alignment POTEB2 and ACT1

DIOPT Version :9

Sequence 1:NP_001264232.1 Gene:POTEB2 / 100287399 HGNCID:48327 Length:544 Species:Homo sapiens
Sequence 2:NP_116614.1 Gene:ACT1 / 850504 SGDID:S000001855 Length:375 Species:Saccharomyces cerevisiae


Alignment Length:303 Identity:59/303 - (19%)
Similarity:116/303 - (38%) Gaps:79/303 - (26%)


- Green bases have known domain annotations that are detailed below.


Human   148 NSEVVQLLLDR---RCQLNVLDNKKRTALIKAV----------------------QCQEDECVLM 187
            :|||..|::|.   .|:.....:....|:..::                      :.|....:|.
Yeast     2 DSEVAALVIDNGSGMCKAGFAGDDAPRAVFPSIVGRPRHQGIMVGMGQKDSYVGDEAQSKRGILT 66

Human   188 L---LEHGADGNIQDEYGNTALHYAIYNEDKLMAK--ALLLYGADIESK-NKCGLTPLLLGVHEQ 246
            |   :|||...|..|.  ....|:..|||.::..:  .:||..|.:..| |:..:|.::.    :
Yeast    67 LRYPIEHGIVTNWDDM--EKIWHHTFYNELRVAPEEHPVLLTEAPMNPKSNREKMTQIMF----E 125

Human   247 KQEVVKFLIKKKANLNALDRYGRTALILAVCCGSASIV---------NLLLEQNVDVSSQDLSGQ 302
            ...|..|.:..:|.|:.......|.::|....|...:|         :.:|  .:|::.:||:..
Yeast   126 TFNVPAFYVSIQAVLSLYSSGRTTGIVLDSGDGVTHVVPIYAGFSLPHAIL--RIDLAGRDLTDY 188

Human   303 -----TAREYAVSSHHHVICELLSDYKEK---------QMLKISSENSNPEQDLKLTSEE----E 349
                 :.|.|:.|:...  .|::.|.|||         |.::.::::|:.|:..:|...:    .
Yeast   189 LMKILSERGYSFSTTAE--REIVRDIKEKLCYVALDFEQEMQTAAQSSSIEKSYELPDGQVITIG 251

Human   350 SQRLKVSEN-SQPEKMSQEP---------EINKDCDREVEEEI 382
            ::|.:..|. ..|..:..|.         .|.| ||.:|.:|:
Yeast   252 NERFRAPEALFHPSVLGLESAGIDQTTYNSIMK-CDVDVRKEL 293

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
POTEB2NP_001264232.1 ANK 130..255 CDD:238125 27/137 (20%)
ANK 1 135..167 6/21 (29%)
ANK repeat 137..166 CDD:293786 6/20 (30%)
ANK 2 168..200 8/56 (14%)
ANK repeat 168..199 CDD:293786 8/55 (15%)
ANK 196..320 CDD:238125 28/140 (20%)
ANK 3 201..233 8/34 (24%)
ANK repeat 201..232 CDD:293786 8/33 (24%)
ANK 4 234..266 5/31 (16%)
ANK repeat 234..265 CDD:293786 5/30 (17%)
ANK 5 267..299 6/40 (15%)
ANK repeat 267..298 CDD:293786 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..457 13/65 (20%)
SMC_N <412..>542 CDD:330553
CCDC144C 489..>542 CDD:317340
ACT1NP_116614.1 NBD_sugar-kinase_HSP70_actin 1..375 CDD:418402 59/303 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5277
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100127
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.710

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