Protein Alignment MED16 and SIN4

DIOPT Version :10

• Sequence 1: NP_005472.2
• Gene: MED16 / 10025
• HGNCID: 17556
• Length: 877
• Species: Homo sapiens
• Sequence 2: NP_014163.1
• Gene: SIN4 / 855485
• SGDID: S000005180
• Length: 974
• Species: Saccharomyces cerevisiae
• Alignment Length: 1033
• Identity: 178/1033 - (17%)
• Similarity: 322/1033 - (31%)
• Gaps: 403/1033 - (39%)

Human    21 WEKWSKSTHCPSVPLACAWSCRNLIAFTM-------DLRSDDQDLTRMI---------HIL---- 65
            |..|.      |:|......|..|...||       |..:..:.||.:.         |::
Yeast   110 WNNWF------SLPGDMLAVCDELGNMTMLITGQRPDRATTYEKLTMVFQDNVYKIYNHVMPLKP 168

Human    66 -DTEHPWDLH--SIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSL-- 125
             |...|.::.  ....|::.:|....|..|...::       :..:...|..:|::.|....:
Yeast   169 VDKLKPMNIERKQTRKEYNTSILEFRWLTSSKSVI-------VSQFCAFDSSSNTYRSRAQQVPP 226

Human   126 --VEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLV 188
              |...|.:..:        .|.:.|:|...|..:||..|....:||
Yeast   227 YGVYHPPFIKYA--------CLAIRKNGQIDFWYQFSNSKDHKKITL------------------ 265

Human   189 TVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKC 253
              .||..|.|.....:.|       ..|.|........::.|.....:..:.|||:.|:......
Yeast   266 --QLLDTSNQRFKDLQWL-------EFARITPMNDDQCMLITTYSKLSKNISFYKLHVNWNLNAT 321

Human   254 RIDTEILPSL---FMRCTTDLNRKDKFPAITHLKFL--------ARDMSEQVL----LCASSQTS 303
            :.:....|||   |:..|| |:..|....:..|:.|        .:|.|.::|    :|.:|:
Yeast   322 KPNVLNDPSLKIQFILSTT-LDPTDDEGHVLKLENLHVVSKSSIEKDPSPEILVLYNVCDTSK-- 383

Human   304 SIVECWSLRKEGL------------------PVNNIFQQISPVVGDKQPTILKWRILSATNDLDR 350
            |:|:.:.|....|                  ..|.|||                   |...:|.|
Yeast   384 SLVKRYRLAPTQLSAEYLVILKPDLNIDRNNSTNQIFQ-------------------SRRYNLRR 429

Human   351 VSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHR--LSLQTMAVFYSSAAPRP 413
            .|.:.|.| .::|..:::..|. ..||        |.||::...::  ..|:|..:...|
Yeast   430 HSDIVLDK-KVTLITSEMFDAF-VSFY--------FEDGTIESYNQNDWKLETERLISQS----- 479

Human   414 VDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLL 478
                      ..|...::.|..||      .|. ::|||.   |.||:
Yeast   480 ----------QLGKFKNIIASPLS------AGF-NYGKLP---LPPSV----------------- 507

Human   479 EYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQ---------VLSTRI-------- 526
                    :|    :.|.|||...:|::.::::.:..||:|:         :.:|.:
Yeast   508 --------EW----MKVSPSMCGVIVKQYNKKWPQFYAAVQKNYADPEKDSINATALAFGYVKSL 560

Human   527 ----------LAMKASLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLT 581
                      :|.|..:.::|.....|..::        |::.||||.  .|.|....:|.:.:.
Yeast   561 HKQISAEDLTIAAKTHILRISFLDRKRAKEF--------ITTLLKSLY--SFFNISPDAPKEIMD 615

Human   582 EICT-----KITDVDID--------------KVMINLKTEEFVLD-------------------- 607
            :|.|     ||..:.::              :|::.||...|..:
Yeast   616 KIITSRPLQKIMLLQLELGSCFSQENIEEMARVILYLKNVLFAFNGVARNFHFAIEQISNNSNQQ 680

Human   608 -----MNTLQALQQLL-------QWVGDFVLYLLASLPNQGSLLRPGHSFLRDGTS--------- 651
                 ..|:.:.|.|:       :|...|:.||     .|..|:     .:.|.|:
Yeast   681 QNPKLFQTIFSKQDLIHSLIPVAKWFVKFITYL-----TQEILI-----LINDPTNKEYTLVHGI 735

Human   652 ----------LGMLRELMVVIRIWGLLKPSCLPVYTATS------------DTQDSMSLLFRLLT 694
                      |.:|.|:..|.:|......:..|:...:|            |.:...:.|..:..
Yeast   736 FGAKMSRTLILSILNEIKKVTQIVAKFPETSYPILNESSTFLKLVLSESPVDFEKFETFLVDVNN 800

Human   695 KLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLP 759
            |....| ::.|:.|.:.:|:.:..:.|....:.......|::.::|.                 .
Yeast   801 KFIALC-EQQPSQEREFSLLVKAEIPPEYAKVGDFLLQYANNAVISH-----------------A 847

Human   760 GSAATLQLD--GLARAPGQ---PKIDHLRRLHLGACPTEE------------------------- 794
            .:||....|  ||..:..:   |:|.||.:      |.||
Yeast   848 NAAAVYFADTSGLKISNSEFFNPEIFHLLQ------PLEEGLIIDTDKLPIKNRTSKSFSKLLYD 906

Human   795 ---C-------------KACTRCGCVTM---LKSPNRT---TAV--KQWEQRWIKNCL 828
               |             |.|:|||.||.   :.|.::|   |::  |:|...:.:.|:
Yeast   907 DVTCDKLSVSEISDGKLKRCSRCGSVTRAGNIISSDKTIVPTSIQTKRWPTMYTRLCI 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED16	NP_005472.2	WD 1	21..71		13/70 (19%)
		WD40	70..109	CDD:197651	5/40 (13%)
		WD 2	72..119		6/48 (13%)
		WD40 repeat	85..116	CDD:293791	3/30 (10%)
		Med16	119..828	CDD:371639	157/910 (17%)
		WD 3	120..165		10/48 (21%)
		WD40 repeat	153..204	CDD:293791	10/50 (20%)
		WD 4	166..203		6/36 (17%)
		WD 5	204..257		8/52 (15%)
		WD 6	258..334		23/108 (21%)
		WD 7	335..415		16/81 (20%)
		WD 8	416..460		9/43 (21%)
		WD 9	461..495		1/33 (3%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	848..877
SIN4	NP_014163.1	Med16	178..971	CDD:371639	164/959 (17%)