Protein Alignment MED16 and med16

DIOPT Version :10

• Sequence 1: NP_005472.2
• Gene: MED16 / 10025
• HGNCID: 17556
• Length: 877
• Species: Homo sapiens
• Sequence 2: XP_012821135.1
• Gene: med16 / 780097
• XenbaseID: XB-GENE-967800
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 818
• Identity: 664/818 - (81%)
• Similarity: 735/818 - (89%)
• Gaps: 4/818 - (0%)

Human    13 MDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRSDDQ-DLTRMIHILDTEHPWDLHSI 76
            ||:.|||||:|..:::||||:||.||||||||||||.|.|:::: |:|.:|||||||||||::||
 Frog     1 MDVGYVCEWDKRPRTSHCPSIPLVCAWSCRNLIAFTTDQRNEEEKDITNLIHILDTEHPWDVYSI 65

Human    77 PSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESSVGSLVEGDPIVALSWLHNGV 141
            .|.|.|.||.|||||||||||||||||:||||.|.|||||||:|.|||.|:||||||||||||||
 Frog    66 NSGHQEVITSLEWDQSGSRLLSADADGRIKCWGMTDHLANSWQSLVGSEVDGDPIVALSWLHNGV 130

Human   142 KLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESL 206
            ||||||||||.|||||||||||||||||||||||||||||||||||||||||||:|||||:||||
 Frog   131 KLALHVEKSGVSSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPNGQVLTATESL 195

Human   207 CRLRGRVALADIAFTGGGNIVVATADGSSASPVQFYKVCVSVVSEKCRIDTEILPSLFMRCTTDL 271
            ||||.|||||||||||||||||||.||||.|||||||||||||||||:||||||||||||||||.
 Frog   196 CRLRCRVALADIAFTGGGNIVVATCDGSSTSPVQFYKVCVSVVSEKCKIDTEILPSLFMRCTTDP 260

Human   272 NRKDKFPAITHLKFLARDMSEQVLLCASSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTI 336
            .|||||||:|||||||||||||||||||:|.|||.|||||||||||:||||||:||.|.||||.|
 Frog   261 ARKDKFPAVTHLKFLARDMSEQVLLCASNQCSSIAECWSLRKEGLPLNNIFQQLSPAVSDKQPMI 325

Human   337 LKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQT 401
            ||||||||||:|:||||||||||||||||||:||||:|:||||||||||||||:|.||||||||.
 Frog   326 LKWRILSATNELERVSAVALPKLPISLTNTDIKVASETKFYPGLGLALAFHDGNVQIVHRLSLQP 390

Human   402 MAVFYSSAAPRPVDEPAMKRPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLE 466
            |||.|.|:. ||.:||::||.|:..|.:|.||:|:|||||||||:|:.||||:||:||||||.|:
 Frog   391 MAVLYGSSL-RPSEEPSLKRQRSPTPCIHFKALQMSWTSLALVGLDTQGKLSMLRVSPSMGHSLD 454

Human   467 VGLALRHLLFLLEYCMVTGYDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKA 531
            :..:|||||||||||||||||||||||||||.||.:|||||:||||||.||||||||||||||||
 Frog   455 MSTSLRHLLFLLEYCMVTGYDWWDILLHVQPGMVHNLVEKLNEEYTRQNAALQQVLSTRILAMKA 519

Human   532 SLCKLSPCTVTRVCDYHTKLFLIAISSTLKSLLRPHFLNTPDKSPGDRLTEICTKITDVDIDKVM 596
            ||||||..|||||||||.|||||:||.|||||||||.||||||||||||||||.|.||.||||||
 Frog   520 SLCKLSQTTVTRVCDYHAKLFLISISCTLKSLLRPHVLNTPDKSPGDRLTEICNKFTDTDIDKVM 584

Human   597 INLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPN-QGSLLRPGHSFLRDGTSLGMLRELMV 660
            ||||||||||||.|||:||||:||:||||||||||||| |||.:||||||||||.|||.|||:||
 Frog   585 INLKTEEFVLDMPTLQSLQQLIQWLGDFVLYLLASLPNQQGSSVRPGHSFLRDGASLGTLREMMV 649

Human   661 VIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLL 725
            :|||||||||||||||||||||||||||||||||:||:|||||....:|||:|:|||||||||||
 Frog   650 MIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTRLWLCCRDESHPCDPDESLIDECCLLPSQLL 714

Human   726 IPSLDWLPASDGLVSRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKIDHLRRLHLGAC 790
            ||::||||..:|::||||.|.|||||||:.|..| |.|::|.:...|:|.|||||||||||||..
 Frog   715 IPNMDWLPLGNGIISRLQSKLPLRLQFGKPPVAP-SYASVQYEAYTRSPTQPKIDHLRRLHLGTF 778

Human   791 PTEECKACTRCGCVTMLKSPNRTTAVKQWEQRWIKNCL 828
            |||.||:||||||||||||||:.||||||||||||.||
 Frog   779 PTEPCKSCTRCGCVTMLKSPNKATAVKQWEQRWIKTCL 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED16	NP_005472.2	WD 1	21..71		32/50 (64%)
		WD40	70..109	CDD:197651	30/38 (79%)
		WD 2	72..119		36/46 (78%)
		WD40 repeat	85..116	CDD:293791	26/30 (87%)
		Med16	119..828	CDD:371639	585/709 (83%)
		WD 3	120..165		40/44 (91%)
		WD40 repeat	153..204	CDD:293791	48/50 (96%)
		WD 4	166..203		35/36 (97%)
		WD 5	204..257		48/52 (92%)
		WD 6	258..334		65/75 (87%)
		WD 7	335..415		65/79 (82%)
		WD 8	416..460		27/43 (63%)
		WD 9	461..495		27/33 (82%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	848..877
med16	XP_012821135.1	WD40	67..97	CDD:197651	24/29 (83%)
		WD40 repeat	74..112	CDD:293791	31/37 (84%)
		Med16	108..823	CDD:371639	587/711 (83%)
		WD40 repeat	142..193	CDD:293791	48/50 (96%)