DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment MED16 and MED16

DIOPT Version :10

Sequence 1:NP_005472.2 Gene:MED16 / 10025 HGNCID:17556 Length:877 Species:Homo sapiens
Sequence 2:NP_611650.2 Gene:MED16 / 37535 FlyBaseID:FBgn0034707 Length:818 Species:Drosophila melanogaster


Alignment Length:883 Identity:253/883 - (28%)
Similarity:400/883 - (45%) Gaps:148/883 - (16%)


- Green bases have known domain annotations that are detailed below.


Human    13 MDLAYVCEWEKWSKSTHCPSVPLACAWSCRNLIAFTMDLRS-----------DDQDL-------- 58
            |.:.|..|.:::||.:..|...:.|:.|.||::||:. |:|           .|..|        
  Fly     1 MTILYKVEGKEFSKDSVFPHKKVLCSVSARNIVAFSA-LQSAIFPASHGGDAGDGSLPGAGLAVG 64

Human    59 --TRMIHILDTEHPWDLHSIPSEHHEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESS 121
              ...:::.|...||:.:.:.|. ...|:.|:|..:|.:||.....|:::.|...:...|.|...
  Fly    65 ASNSHVYVCDIVTPWEYYKVCSS-KSLISVLQWSPNGEQLLLGYVGGRVEIWQPRNQSINLWVLQ 128

Human   122 VGSLVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFS-PSLTLFGGKPMEGWIAVTVS 185
            ..:.|..:.|:...:..||..:..:..|...:.:.|||.||:.. |:|:.|||...||.:.:|.|
  Fly   129 YYATVPSEDIIEAQFFQNGKGVIFNALKKDHTYYAEKFERVEQQRPTLSGFGGVASEGCVLLTSS 193

Human   186 GLVTVSLLK------------PSGQVLTSTESLCRL---RGRVALADIAFTGGGNIVVATADGSS 235
            ||:....|.            |:.:|:..|.:|..:   |..:....:..:..|.:.:|.:.|..
  Fly   194 GLLAAFSLPAIQKTSAAGADGPAHEVVELTPALHSIGISRSFIEHCSMTPSPSGALNIAFSCGWQ 258

Human   236 ASPVQFYKVCVSV-----VSEKCRIDTEILPSLFMRCTTDLNRKDKFPAITHLKFLARDMSEQVL 295
            ...||.:||.:|:     :.:...|.:|...|:|:. ..|..|      |:|||: .|..:|.|:
  Fly   259 QQLVQCFKVSLSLEGELGLEQHLAIKSESQTSIFLG-PLDGRR------ISHLKW-TRIANEDVI 315

Human   296 LCA---SSQTSSIVECWSLRKEGLPVNNIFQQISPVVGDKQPTILKWRILSATNDLDRVSAVAL- 356
            ..|   .....|.:|.|:|.:....|:.:.|. .....:|....::      :...::|..|.| 
  Fly   316 FIAYACPDGAGSQLEQWTLTRRHQSVHALLQG-GGGANNKPNEFVQ------SESWEQVGKVQLN 373

Human   357 -PKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAVFYSSAAPRPVDEPAMK 420
             ....||:|...:......|.|..|      .|.||.::...|:            :.::.....
  Fly   374 ASLADISVTRLSVSTPDSCQVYAIL------QDNSVQVLEPNSM------------KQLNHTQFD 420

Human   421 RPRTAGPAVHLKAMQLSWTSLALVGIDSHGKLSVLRLSPSMGHPLEVGLALRHLLFLLEYCMVTG 485
            |...|..||...:..|:.:|..|:..|||.:|..:: :|.   |.:.|..    |.|||||:|||
  Fly   421 RLSDASGAVKFVSGDLTPSSQILLIFDSHAQLYAMQ-APL---PKQGGSG----LLLLEYCIVTG 477

Human   486 YDWWDILLHVQPSMVQSLVEKLHEEYTRQTAALQQVLSTRILAMKASLCKLSPCTVTRVCDYHTK 550
            .|..|:|| :....:::|||||.:.:|||.:.::.......||:|:::|::      :..::...
  Fly   478 CDASDVLL-LNLGNLEALVEKLTDNFTRQPSFVRHFYYANFLALKSNICRM------QQQEFDNL 535

Human   551 LFLIAISSTLKSLLRPHFLNTPDKSPGDRLT-EICTKITDVDIDKVMINLKTEEFVLDMNTLQAL 614
            :.|.|||:|.||||||..|...||.|.|.|. ::...|.||  |.||:||..::|.::...||:|
  Fly   536 IILHAISTTFKSLLRPSDLGFQDKGPADNLAIKLAESIPDV--DTVMLNLDAKDFTVEPVMLQSL 598

Human   615 QQLLQWVGDFVLYLLASLPNQG-----SLLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLP 674
            |||:|||.|..|.:|..||.:.     |..||.:...||..::..||||:|:|||||||...|||
  Fly   599 QQLIQWVTDLALNMLHRLPEEVMKTKLSGKRPSYDISRDIVAISSLRELLVMIRIWGLLNTQCLP 663

Human   675 VYTATSDTQDSMSLLFRLLTKLWICCRDEGPASEPDEALVDECCLLPSQLLIPSLDWLPASDGLV 739
            |||.|.|..|.:.:||||||:|     .:.|| ||||.|:|||.||..|||||.          .
  Fly   664 VYTKTMDNIDVLVILFRLLTRL-----AQNPA-EPDEMLLDECSLLSKQLLIPQ----------P 712

Human   740 SRLQPKQPLRLQFGRAPTLPGSAATLQLDGLARAPGQPKI----------------DHLRRLHLG 788
            ::..|...|..| |.|....|.   ||...:.    :|..                |.:..|.||
  Fly   713 TKFNPTTLLSAQ-GFAAVKSGQ---LQFTSME----EPTCLQDMETEEVVFASSVKDGVSNLQLG 769

Human   789 ACPTEECKACTRCGCVTMLKSPN--RTTAVKQWEQRWI 824
            |.|: ..:.|.|||.|.:..:..  :|:|:|.|..:|:
  Fly   770 ARPS-HIRRCARCGFVFVNNASKVAKTSALKAWFSKWL 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MED16NP_005472.2 WD 1 21..71 14/70 (20%)
WD40 70..109 CDD:197651 10/38 (26%)
WD 2 72..119 10/46 (22%)
WD40 repeat 85..116 CDD:293791 7/30 (23%)
Med16 119..828 CDD:371639 223/756 (29%)
WD 3 120..165 10/44 (23%)
WD40 repeat 153..204 CDD:293791 19/63 (30%)
WD 4 166..203 14/48 (29%)
WD 5 204..257 11/60 (18%)
WD 6 258..334 20/78 (26%)
WD 7 335..415 13/81 (16%)
WD 8 416..460 11/43 (26%)
WD 9 461..495 15/33 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 848..877
MED16NP_611650.2 Med16 128..816 CDD:371639 220/735 (30%)
Blue background indicates that the domain is not in the aligned region.

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