DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ptpn23 and Ptp61F

DIOPT Version :9

Sequence 1:	XP_031759128.1	Gene:	ptpn23 / 100217320	XenbaseID:	XB-GENE-996513	Length:	1934	Species:	Xenopus tropicalis
Sequence 2:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	240/550 - (43%)	Gaps:	85/550 - (15%)

- Green bases have known domain annotations that are detailed below.

Frog  1432 RFRVVVEALDKPVPGASTQLDSMWKEFQEAQEKEARQQSIAIARC--YTMK--NRHQDIMPYDKN 1492
            |.::..|..||     ..|....:||..|..::||:::..:.:..  :|.:  ||::|:.|||.:
  Fly    16 RLQIEAEYKDK-----GPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHS 75

Frog  1493 RIILQSGKDDYINASKIEDLSSYCPSIIATQAPLVGTASDFWLMIHEQKVSLIVMLVSEQEIEKQ 1557
            ||:|:.|..|||||:.:: |.......|.||.|||.|...||||:.|||...::||....|.::.
  Fly    76 RIVLKRGSVDYINANLVQ-LERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQI 139

Frog  1558 KVLRYFPLERG--QAMVHGHISLTL------TSQ-------KVTDIHVERVLSLQYKDQSLKRSI 1607
            |...|:|.|.|  :|:...|:.||:      |.|       |:||:..::           .|.:
  Fly   140 KCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQ-----------SREV 193

Frog  1608 IHLQFTSWPELGLPDSKGNLLRFIQEVHSHYLHQRPLHTPIVVHCSSGVGRTGAFCLMYAAMQEV 1672
            :...:|:||:.|:|.|....|:|:|:|.......|.: .|.|||||:|:||:|.|||:...:..:
  Fly   194 MQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDV-GPAVVHCSAGIGRSGTFCLVDCCLVLI 257

Frog  1673 EAGNGIPDLAELVKKMRQQRKYMLQEKIHLKFCYEAVLKHAEQVLQRHGVCTPSSSKPQHSTPLK 1737
            :. .|..::::::.::|..|..::|....|.|.|:|::   |.:.:.|......:.:|..|...:
  Fly   258 DK-YGECNVSKVLCELRSYRMGLIQTADQLDFSYQAII---EGIKKLHDPTFLDAEEPLISNDTE 318

Frog  1738 LYTVQD-PQDI---VLGGDMPISSIQATIAKLSIKPC-PGGTENPASYQLPPTLDSWANEPATSN 1797
            .:|:.: |..:   |...::|::.....|..|:::.. ..|.|:.........|:::.|:  ...
  Fly   319 THTLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQ--HDM 381

Frog  1798 VLPPEVPSSTPQPDLTPMAVS---------------------MEYQPSQTLPPAAANGNSVLLTE 1841
            :...||..|.|.|.|...|.:                     .||:..........||:....|:
  Fly   382 IHDAEVADSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQ 446

Frog  1842 SAAD---VSNHLPMAAGEAVPKA---EPPPVTSTTASSSSL------NLLASLTAEAFNLDSAQK 1894
            ..||   .:|..|....:...||   :|.|.....:..:.|      ...|||..:..::...|:
  Fly   447 PHADDVNANNEKPAVPVDEQHKANGIDPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQR 511

Frog  1895 GKQ----KMSKQNFLQPQNGGGLVRGSMAA 1920
            ..:    ...|:..|......|:|.|.:.|
  Fly   512 ENEDKQLAAKKRRSLLTYIAAGVVVGVICA 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ptpn23	XP_031759128.1	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..699	CDD:185747
		PHA03247	<763..1227	CDD:223021
		Atrophin-1	1162..>1348	CDD:397323
		PTP-N23	1503..1707	CDD:350387	67/218 (31%)
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	86/277 (31%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	80/249 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910