DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf150 and RNF150

DIOPT Version :9

Sequence 1:	NP_001135553.1	Gene:	rnf150 / 100216098	XenbaseID:	XB-GENE-5993052	Length:	427	Species:	Xenopus tropicalis
Sequence 2:	XP_005263207.1	Gene:	RNF150 / 57484	HGNCID:	23138	Length:	460	Species:	Homo sapiens

Alignment Length:	461	Identity:	359/461 - (77%)
Similarity:	389/461 - (84%)	Gaps:	35/461 - (7%)

- Green bases have known domain annotations that are detailed below.

Frog     1 MAMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYTDPL-----------SH 54
            |||||||||.||||||||||||||||||||||||||||||||||||||.:|.           ..
Human     1 MAMSLIQACCSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYAEPAPDPGAGAAGGGGA 65

Frog    55 QWRTEKSECGRYGEHSLKQDAWGLAVMPSSPQDRLACDPATKFSVPANASRWVALIPKGNCTYRD 119
            :..|||:|||||||||.||||.|..||.||..|||||||.|||:.|.....|:||||||||||||
Human    66 ELHTEKTECGRYGEHSPKQDARGEVVMASSAHDRLACDPNTKFAAPTRGKNWIALIPKGNCTYRD 130

Frog   120 KIKHAALQNASAVLIYNVGSSNANETITMPH----------------------PGIEDIVAIMIP 162
            ||::|.|||||||:|:||| ||.||||||||                      .|:|||||||||
Human   131 KIRNAFLQNASAVVIFNVG-SNTNETITMPHAGLMSSHAQPLKLISPCPYSLSSGVEDIVAIMIP 194

Frog   163 EPKGREIATLLERNINVTIYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 227
            ||||:||.:||||||.||:||||||||||||||||||||||||||||||||||||||||||||||
Human   195 EPKGKEIVSLLERNITVTMYITIGTRNLQKYVSRTSVVFVSISFIVLMIISLAWLVFYYIQRFRY 259

Frog   228 ANARDRNQRRLGDAAKKAISKLQVRTIKKGDKETEPEFDNCAVCIEGYKPNDVVRILPCRHLFHK 292
            |||||||||||||||||||||||:|||||||||||.:||||||||||||||||||||||||||||
Human   260 ANARDRNQRRLGDAAKKAISKLQIRTIKKGDKETESDFDNCAVCIEGYKPNDVVRILPCRHLFHK 324

Frog   293 SCVDPWLLDHRTCPMCKMNILKALGIPPNADCLDDIPPDFEGSV-GPPTNQITGASDVTVNESSV 356
            ||||||||||||||||||||||||||||||||:||:|.|||||: ||||||||||||.|||||||
Human   325 SCVDPWLLDHRTCPMCKMNILKALGIPPNADCMDDLPTDFEGSLGGPPTNQITGASDTTVNESSV 389

Frog   357 GIDPSVRTVGVLQVIQDAESLPQVGEVSYTASSEQEPAVSSDSDISLIMAVDVGLSDVDLSTDQD 421
            .:||:|||||.|||:||.:.:||.|:|.:|.:||||||||||||||||||::||||||:||||||
Human   390 TLDPAVRTVGALQVVQDTDPIPQEGDVIFTTNSEQEPAVSSDSDISLIMAMEVGLSDVELSTDQD 454

Frog   422 CDEAKS 427
            |:|.||
Human   455 CEEVKS 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf150	NP_001135553.1	PA_GRAIL_like	45..183	CDD:239037	98/170 (58%)
		UPF0233	<197..>222	CDD:299753	24/24 (100%)
		zf-RING_2	266..309	CDD:290367	42/42 (100%)
RNF150	XP_005263207.1	PA_GRAIL_like	45..215	CDD:239037	98/170 (58%)
		UPF0233	<229..>254	CDD:299753	24/24 (100%)
		zf-RING_2	298..341	CDD:290367	42/42 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I16291
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	1	1.050	725	1.000	Inparanoid score	I5115
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto154702
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110