DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf150 and rnf150a

DIOPT Version :9

Sequence 1:	NP_001135553.1	Gene:	rnf150 / 100216098	XenbaseID:	XB-GENE-5993052	Length:	427	Species:	Xenopus tropicalis
Sequence 2:	NP_001139044.1	Gene:	rnf150a / 559804	ZFINID:	ZDB-GENE-060213-1	Length:	418	Species:	Danio rerio

Alignment Length:	428	Identity:	298/428 - (69%)
Similarity:	353/428 - (82%)	Gaps:	11/428 - (2%)

- Green bases have known domain annotations that are detailed below.

Frog     1 MAMSLIQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYTDPLSHQWRTEKSECGR 65
            |.:||.||||||||||||||||||||||||||||||||||||||||||.||::.:.:|::|||||
Zfish     1 MVVSLTQACRSLALSTWLLSFCFVHLLCLDFTVAEKEEWYTAFVNITYLDPVTSEIKTDRSECGR 65

Frog    66 YGEHSLKQDAWGLAVMPSSPQDRLACDPATKFSVPANASRWVALIPKGNCTYRDKIKHAALQNAS 130
            |||||.|:||.|...|   ||||.|||..|:|.:|..:..|:|||.|||||:|:||:|||..|||
Zfish    66 YGEHSPKRDARGFVFM---PQDRQACDGNTRFPLPHPSIPWIALIAKGNCTFREKIRHAAALNAS 127

Frog   131 AVLIYNVGSSNANETITMPHPGIEDIVAIMIPEPKGREIATLLERNINVTIYITIGTRNLQKYVS 195
            ||:|:||||||:|:||||||.|..|:|||||||||||||..|||:||.|.::|:|||||||||||
Zfish   128 AVVIFNVGSSNSNDTITMPHHGTGDVVAIMIPEPKGREIMALLEKNITVAMHISIGTRNLQKYVS 192

Frog   196 RTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQVRTIKKGDKE 260
            ||||||||||||||||||||||||||||||||||||||:||||||||||||||||||||:|||||
Zfish   193 RTSVVFVSISFIVLMIISLAWLVFYYIQRFRYANARDRSQRRLGDAAKKAISKLQVRTIRKGDKE 257

Frog   261 TEPEFDNCAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCL 325
            |:.:|||||||||.||||||||||||||:||::||||||.|||||||||||||||||||||.||.
Zfish   258 TDSDFDNCAVCIEDYKPNDVVRILPCRHVFHRNCVDPWLQDHRTCPMCKMNILKALGIPPNTDCS 322

Frog   326 DDIPPDFEGSVGPPTNQITGASDVTVNESSVGIDPSVRTVGVLQVIQDAESLPQVGEVSYTASSE 390
            ||.|||:|.|.|.|:..:||||:|:|.|||:.:|..:|..|:....|:..|:|...|..:.||||
Zfish   323 DDAPPDYETSSGQPSIAVTGASEVSVGESSLVLDQPLRITGLSHDYQEMNSVPADAESPHIASSE 387

Frog   391 Q-EPAVSSDSDISLIMAVDVGLSDVDLSTDQDCDEAKS 427
            | :|::|:|.|   ||.:::    .:|.:|.:.::.||
Zfish   388 QHQPSMSNDPD---IMPMEI----AELQSDLEQEDVKS 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf150	NP_001135553.1	PA_GRAIL_like	45..183	CDD:239037	87/137 (64%)
		UPF0233	<197..>222	CDD:299753	24/24 (100%)
		zf-RING_2	266..309	CDD:290367	37/42 (88%)
rnf150a	NP_001139044.1	PA_GRAIL_like	45..180	CDD:239037	87/137 (64%)
		UPF0233	<194..>219	CDD:299753	24/24 (100%)
		zf-RING_2	263..306	CDD:290367	37/42 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I26368
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H33783
Inparanoid	1	1.050	601	1.000	Inparanoid score	I5280
OMA	1	1.010	-	-		QHG50669
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto75555
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110