DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf150 and H10E21.5

DIOPT Version :9

Sequence 1:	NP_001135553.1	Gene:	rnf150 / 100216098	XenbaseID:	XB-GENE-5993052	Length:	427	Species:	Xenopus tropicalis
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	392	Identity:	126/392 - (32%)
Similarity:	187/392 - (47%)	Gaps:	109/392 - (27%)

- Green bases have known domain annotations that are detailed below.

Frog    24 VHLLCLD-----------FTVAEKEEWYTAFVNITYTDPLSHQWRTEKSE----CGRYGEHSLKQ 73
            |.|.|:|           .|.:.|:...:.|:. .|||..:...:.:.|:    |....::.|.:
Worm    30 VKLQCIDSEEVYGTLQTELTFSNKDGGGSTFLP-AYTDLCAPDMKFDDSQRVFFCKNCIQNCLSR 93

Frog    74 DAWGLAVMPSSPQDRLACDPATKFSVPANASRWVAL-IPKGNCTYRDKIKHAALQNASAVLIYNV 137
                   :.::|::.|.   ......|.|...|..: .|..|      |:.:..|       .||
Worm    94 -------VETAPKNILI---VADVKAPNNRVSWFHVQTPVSN------IRESGKQ-------CNV 135

Frog   138 GSSNANETITMPHPGIEDIVAIMIPEPKGREIATLLERNINVTIYITIGTRNLQKYVSRTSVVFV 202
            .:|||.::                ||    |.:|...|:.                 |:|||:||
Worm   136 ENSNAMQS----------------PE----ETSTDALRSF-----------------SKTSVLFV 163

Frog   203 SISFIVLMIISLAWLVFYYIQRFRYANARDRNQRRLGDAAKKAISKLQVRTIKKGDKETEPEFDN 267
            |||||:||:||||||||||:||||||:|:||.||||.:||:||::::...||..|  .|:....:
Worm   164 SISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPG--MTQELQSD 226

Frog   268 CAVCIEGYKPNDVVRILPCRHLFHKSCVDPWLLDHRTCPMCKMNILKALGIPPNADCLDDIPPDF 332
            ||||::.|:..||:|:|||:|::||||:|||||:||||||||.:|||..|.      .:||..|.
Worm   227 CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGY------WNDIRNDI 285

Frog   333 EGSVGPPTNQITGASDVTVNESSVGIDPSVRTVGVLQVIQDAESLPQVGEVSYTASSEQEPAVSS 397
            :    .|||....|.|.|:.               |::.:.....|....:|..|:|:     :|
Worm   286 Q----MPTNSRGIADDFTIR---------------LELGEQEHQAPSADVISPEANSD-----TS 326

Frog   398 DS 399
            ||
Worm   327 DS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf150	NP_001135553.1	PA_GRAIL_like	45..183	CDD:239037	25/142 (18%)
		UPF0233	<197..>222	CDD:299753	21/24 (88%)
		zf-RING_2	266..309	CDD:290367	27/42 (64%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	92/223 (41%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	30/46 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I5695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm21426
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3602
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.040