DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CDH4 and cdh4

DIOPT Version :9

Sequence 1:	NP_001785.2	Gene:	CDH4 / 1002	HGNCID:	1763	Length:	916	Species:	Homo sapiens
Sequence 2:	NP_571161.2	Gene:	cdh4 / 30297	ZFINID:	ZDB-GENE-991207-1	Length:	931	Species:	Danio rerio

Alignment Length:	947	Identity:	622/947 - (65%)
Similarity:	732/947 - (77%)	Gaps:	50/947 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MTAGAGVLLLLLSLSGALRAHNEDLTTRETCKAGFSEDDYTALISQNILEG-----EKLL---QV 57
            |..|..:|:....:.|.....:.:..|...|:.|||:..||..:.:.:|:|     :.||   .|
Zfish     4 MKTGCAILVACALVVGTSLGSHWNAQTVAPCRPGFSQSFYTVFVPRVVLQGLNIHKDTLLSSGHV 68

Human    58 KFSSCVGTKGTQYETNSMDFKVGADGTVFATRELQVPSEQVAFTVTAWDSQTAEKWDAVVRLLVA 122
            ||.:|...:...:|::...|.|..||:::|.:::...:|.:.|.|||.|......|:..|:|.:|
Zfish    69 KFETCHRIEELSFESSDPKFSVRPDGSLYAEQDVTNLTEPIQFMVTARDRAGEYIWETTVKLALA 133

Human   123 QTSSPHSGHKPQKGKKVVALDPSPPP-----KDTLLPWPQH---QN--------------ANGLR 165
                   ||            |..||     .:.:...|.|   ||              :||||
Zfish   134 -------GH------------PLSPPFNQIAGEAIYGGPSHYHYQNPRLITFPRQRQRGLSNGLR 179

Human   166 RRKRDWVIPPINVPENSRGPFPQQLVRIRSDKDNDIPIRYSITGVGADQPPMEVFSIDSMSGRMY 230
            |:|||||||||||||||||||||.||.||||:|..|.|||||||.||||||.:||:||.::|:|.
Zfish   180 RQKRDWVIPPINVPENSRGPFPQVLVMIRSDQDKKIEIRYSITGAGADQPPNDVFNIDPVTGKMS 244

Human   231 VTRPMDREEHASYHLRAHAVDMNGNKVENPIDLYIYVIDMNDNRPEFINQVYNGSVDEGSKPGTY 295
            ||:|:|||:.|||||:|||||:|||::|.||||||||||||||||||.||||||||.|||||||.
Zfish   245 VTKPLDREDRASYHLKAHAVDINGNQMEPPIDLYIYVIDMNDNRPEFKNQVYNGSVAEGSKPGTS 309

Human   296 VMTVTANDADDSTTANGMVRYRIVTQTPQSPSQNMFTINSETGDIVTVAAGLDREKVQQYTVIVQ 360
            ||.|||.||||||||||:|.|||::|||..|..||||||..||:|.|:|||:|||||.|||||||
Zfish   310 VMQVTAFDADDSTTANGLVHYRILSQTPHIPIPNMFTINGATGEISTIAAGIDREKVSQYTVIVQ 374

Human   361 ATDMEGNLNYGLSNTATAIITVTDVNDNPPEFTASTFAGEVPENRVETVVANLTVMDRDQPHSPN 425
            |||||||||:||||||||:|:::|:||||||..:.||.||||||.|..|||||||.|:||||:||
Zfish   375 ATDMEGNLNFGLSNTATALISISDINDNPPELDSKTFLGEVPENAVGVVVANLTVRDKDQPHTPN 439

Human   426 WNAVYRIISGDPSGHFSVRTDPVTNEGMVTVVKAVDYELNRAFMLTVMVSNQAPLASGIQMSFQS 490
            |||||||..|||.|||::|||.:||:|.|.|||.||||.|.||||.|:|||||.|||||..|..|
Zfish   440 WNAVYRITGGDPLGHFTIRTDEITNDGRVIVVKPVDYERNGAFMLMVVVSNQAHLASGIPSSPSS 504

Human   491 TAGVTISIMDINEAPYFPSNHKLIRLEEGVPPGTVLTTFSAVDPDRFMQQAVRYSKLSDPASWLH 555
            :|||||:::|:||||.||||.|:||.|||||..|.|.||:|:|||||:||.:|||||||||:||.
Zfish   505 SAGVTITVLDVNEAPVFPSNPKIIRFEEGVPADTTLATFAALDPDRFIQQTIRYSKLSDPANWLK 569

Human   556 INATNGQITTAAVLDRESLYTKNNVYEATFLAADNGIPPASGTGTLQIYLIDINDNAPELLPKEA 620
            ||.|||:|||.|||||||.|.|.|||||||||.|||.|||:|||||||||||:|||.|.|:|:||
Zfish   570 INRTNGRITTTAVLDRESPYMKKNVYEATFLAVDNGSPPATGTGTLQIYLIDVNDNVPVLVPQEA 634

Human   621 QICEKPNLN-AINITAADADVDPNIGPYVFELPFVPAAVRKNWTITRLNGDYAQLSLRILYLEAG 684
            .:||:.... .:||||:|.|.:||.||||||||..|::.|:||||:||||:||||.|||.|||||
Zfish   635 LVCERSRHGYPVNITASDLDSEPNAGPYVFELPSYPSSARRNWTISRLNGNYAQLKLRIPYLEAG 699

Human   685 MYDVPIIVTDSGNPPLSNTSIIKVKVCPCDDNGDCTTIGAVAAAGLGTGAIVAILICILILLTMV 749
            ||.|||:|:|||||||||||::||||||||:|||||.||||..||||||||:.|||||:|||:||
Zfish   700 MYRVPILVSDSGNPPLSNTSVLKVKVCPCDENGDCTVIGAVTVAGLGTGAIITILICIIILLSMV 764

Human   750 LLFVMWMKRREKERHTKQLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPEAMGHVPSKAP 814
            |.||:|:|||||||.||.|||||||||||||||||||||||||||||||||||||::.|:.||..
Zfish   765 LFFVVWVKRREKERQTKPLLIDPEDDVRDNILKYDEEGGGEEDQDYDLSQLQQPESLDHIMSKPA 829

Human   815 GVRRVDERPVGAEPQYPIRPMVPHPGDIGDFINEGLRAADNDPTAPPYDSLLVFDYEGSGSTAGS 879
            ||||||||||..|.|||:||.||||||||:||.:|||||||||||||||||||||||||||||||
Zfish   830 GVRRVDERPVILESQYPVRPTVPHPGDIGEFITDGLRAADNDPTAPPYDSLLVFDYEGSGSTAGS 894

Human   880 VSSLNSSSSGDQDYDYLNDWGPRFKKLADMYGGGEED 916
            ||||:|||||:||||||||||||||||||:||||.||
Zfish   895 VSSLDSSSSGEQDYDYLNDWGPRFKKLADLYGGGGED 931

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDH4	NP_001785.2	Cadherin_pro	30..119	CDD:285913	28/96 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..168		14/65 (22%)
		E_set	173..273	CDD:298831	75/99 (76%)
		Cadherin_repeat	281..388	CDD:206637	81/106 (76%)
		Cadherin_repeat	396..503	CDD:206637	74/106 (70%)
		Cadherin_repeat	514..611	CDD:206637	74/96 (77%)
		E_set	619..711	CDD:298831	62/92 (67%)
		Cadherin_C	769..911	CDD:279398	123/141 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	806..838		20/31 (65%)
cdh4	NP_571161.2	Cadherin_pro	34..128	CDD:214999	27/93 (29%)
		E_set	187..287	CDD:298831	75/99 (76%)
		Cadherin_repeat	295..402	CDD:206637	81/106 (76%)
		Cadherin_repeat	414..517	CDD:206637	71/102 (70%)
		Cadherin_repeat	532..625	CDD:206637	71/92 (77%)
		Cadherin	632..726	CDD:278457	62/93 (67%)
		Cadherin_C	784..926	CDD:279398	123/141 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194343857
Domainoid	1	1.000	280	1.000	Domainoid score	I8245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H48044
Inparanoid	1	1.050	1238	1.000	Inparanoid score	I1497
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG44836
OrthoDB	1	1.010	-	-		D106107at33208
OrthoFinder	1	1.000	-	-		FOG0013385
OrthoInspector	1	1.000	-	-		oto47321
orthoMCL	1	0.900	-	-		OOG6_101517
Panther	1	1.100	-	-	LDO	PTHR24027
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X10891
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.410