DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment chd8 and kis

DIOPT Version :9

Sequence 1:	XP_012812626.1	Gene:	chd8 / 100192376	XenbaseID:	XB-GENE-966847	Length:	2335	Species:	Xenopus tropicalis
Sequence 2:	NP_001137761.1	Gene:	kis / 33185	FlyBaseID:	FBgn0266557	Length:	5517	Species:	Drosophila melanogaster

Alignment Length:	3377	Identity:	1004/3377 - (29%)
Similarity:	1390/3377 - (41%)	Gaps:	1197/3377 - (35%)

- Green bases have known domain annotations that are detailed below.

Frog     7 DLFDDPNLFGLDSLTGDSFG--------------RDGPDTIDDALGLGNVLGPLEPITD------ 51
            ||.:.|......:..|.|.|              ..|.|....|.|:.....|:.|:|.
  Fly  1007 DLQEKPTAEMEQTQLGQSLGDLSKSLLEEPKTVEESGEDKSQSAPGVAPPADPIIPVTQPPQQQM 1071

Frog    52 -RVGLPGADVG-NNEVKQQTESQVLPDNPALMSA---------------TEIMQPIQ----LPTN 95
             .:|:|...:. ..|.:.|.:..:.|..|....|               ..:.|.||    :|..
  Fly  1072 PPIGMPMHPIAPGYEAQAQGQGHMPPMMPPYGGAPGMYPPYPMLHQQEIAALQQQIQELYCMPPG 1136

Frog    96 QETLNQGNPFMGASNAGAPKIMILKAPAGMTVGACPVTQIQTLTPH----QAANGGK-VAFAKV- 154
            .|..:|            .|:|.::            .::..||.|    |.|.|.: :.|..|
  Fly  1137 HELQHQ------------DKLMRMQ------------ERLNLLTQHEVNDQCAGGPQCLLFQNVP 1177

Frog   155 ----LTGTPL-------RPGVSIVSG-------NTVLAKMPSTGVAGQVGAVRPVRQLLLQPVRA 201
                ..|.||       .|.||..:|       |.........|...|||     :|..|..:..
  Fly  1178 PMYGPPGNPLLNQQMVESPQVSSTTGRGRGKSANKPRKPRAKKGEKAQVG-----QQQDLMDISG 1237

Frog   202 SAAPGSSESNTGIKPAITLTSAPQQGDPKRITLVLQQPSQVGATA-QQGQRHVVLGGLPGKIVLQ 265
            :.|.|::.:.:    :|..|..|...|  .:|......|.||... .:|     :|.| .:.|..
  Fly  1238 NVAMGAANAVS----SIPTTQLPVSED--CVTQGAGDTSVVGMLEYSEG-----MGDL-SQDVHS 1290

Frog   266 GNQLAALT----------QAKTPQ--GQPAKVVTIQLQVQQQPGAAGQTPQKFQIVQQAPGGV-A 317
            .|:|...|          :.:||:  .:|.:..|.:.:..:.|.....|        :.|..| .
  Fly  1291 ANELDTSTDGSGKKKKPRKPRTPKDPNKPPRDRTPKAKKPKDPNDPNST--------ETPAAVKK 1347

Frog   318 IAPSGQHTHMLNQQGVQRLSVPLKV----VLQPQAGSSQGTAQGLSVVKVLNASEVANLTASQTV 378
            .|.:.:......:.|.::.....:|    .|.|:|||:.|.|:
  Fly  1348 RAGASKRRKQYGEDGAEQTGEGSEVEDNKPLVPKAGSADGEAE---------------------- 1390

Frog   379 VKTSTGG----GESRKLDS---QKKQEKANRIVAEAIARARARGEQNIPRVLNEDELPSVNPEDD 436
              |::||    |||...|.   .|....:|....||.|     |::.:..|.:....|:..|
  Fly  1391 --TTSGGTGVDGESPDYDDIPVSKIPRGSNEDEKEAEA-----GDETVDSVPDSAGDPASTP--- 1445

Frog   437 DGSRRKRKKKKGETSDRSKDEKPKKVKGSGSLRSRSKGKPSTITPIVGKKRKRN---PSSDNSDA 498
              |||.||:....:...:..|:      .||.|   |.:.|.....:.|:|.|.   |.||..|.
  Fly  1446 --SRRDRKRSTARSRRNANSEE------GGSAR---KNRGSLSAKALKKRRNRGRIVPESDGEDD 1499

Frog   499 EI--MASQASPAEDEDSVQKRRSNRQVKRKKYTEDLDIKITDDEDDEEVDVTGPV---------- 551
            .:  ....:.|.:.|....||||:|..:||||.:|:.::.:|||:  .:.|..||
  Fly  1500 TLDRTPPPSPPPDSEMDSNKRRSSRNTQRKKYIDDVMLRFSDDEN--SLLVASPVKKDKKPSANA 1562

Frog   552 ----------KTEPVLLPE------------PMPLPDS---EAVPSMQFFVE------------- 578
                      ||||....|            .:||.:|   ||..|.....|
  Fly  1563 SNSNAGSDVEKTEPQSGAEGDAAQEVGEEKSNLPLDESSQLEASSSTSAVAEKERQISTDAANAA 1627

Frog   579 ----------NPSEEDAAIVDKILSMRLAKKEL----------------------------PTGE 605
                      |..:||:.:|..:|:||:.|:||                            |.|:
  Fly  1628 MSSKPNYVYINTGDEDSMVVQLVLAMRMGKRELILDKPKEKAPEPKQDEEKSELDEATTDKPEGD 1692

Frog   606 ----------------------------------------------------------------- 605

  Fly  1693 EKFKTEGESKKDLTDSEETKLESSAMEVDSKEESEPDDSKKSDEDNKDKDKMEVDDEVGKSDKES 1757

Frog   606 ----------------------------------------------------------------- 605

  Fly  1758 KPEEQSETVKTEENSKAIEEDKSSTVLTADHAKEPETVLEKMEVDEKANDDQSAVSKAEGSDEKS 1822

Frog   606 -----------------------------------------------------YVEVEEYFVKYK 617
                                                                 :::||||||||:
  Fly  1823 TDDSNPEEATTEKNKESLEIEGEKERVKEGEESVKKENDEKTEADMENKPEPVFIDVEEYFVKYR 1887

Frog   618 NYSYLHCEWATIEQ-LERDKRIHQKLKRFKTKMTQMQHFLQE-DEESFNPDYVEVDRILDESHST 680
            |:|||||||.|.|: |:.|:|:..|::||:.|.:|..:..:. ::|.||.|:.||||:||.|..|
  Fly  1888 NFSYLHCEWRTEEELLKGDRRVAAKIRRFQQKQSQQLNIFENIEDEPFNQDFTEVDRVLDMSVHT 1952

Frog   681 DKDNGEPVVYYLVKWCSLPYEDSTWELKEDVDDGKIEEFKRIE--ARQPNLKRVARPAATSWKKL 743
            |:.:||...:|||||.||||||.||||:||||:.|||::.|..  .::...|...||....||||
  Fly  1953 DETSGETTKHYLVKWKSLPYEDCTWELEEDVDNDKIEQYLRFNKIPQRSEWKSKKRPHPELWKKL 2017

Frog   744 ELSREYQNGNQLREYQLEGVNWLLFNWYNRQNCILADEMGLGKTIQSITFLQEVYNVGIRGPFLV 808
            |.:..|:.||.||.|||||:|||.|:|||..||||||||||||||||:||:..||..||||||||
  Fly  2018 EKTPVYKGGNSLRPYQLEGLNWLKFSWYNTHNCILADEMGLGKTIQSLTFVHSVYEYGIRGPFLV 2082

Frog   809 IAPLSTITNWEREFGSWTQMNTIVYHGSLASRQMIQQYEMYCKDSKGRLIPGAYKFDALITTFEM 873
            |||||||.||:|||..||.||.:|||||:.|:||||.||.|.|...|:::....||:.|||||||
  Fly  2083 IAPLSTIPNWQREFEGWTDMNVVVYHGSVTSKQMIQDYEYYYKTESGKVLKEPIKFNVLITTFEM 2147

Frog   874 VLSDCPELREIEWRCVIIDEAHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFL 938
            :::|..:|:...||..:|||||||||||||||:.|:.::|||:|||:||||||.:.||||||:||
  Fly  2148 IVTDYMDLKAFNWRLCVIDEAHRLKNRNCKLLEGLRQLNLEHRVLLSGTPLQNNISELFSLLNFL 2212

Frog   939 EPTQFSSEAEFLKDFGDLKTEEQVQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKK 1003
            ||:||||:.||:.:||.|:|||:|.||||:||||||||||:||||:||||:||||||||||||||
  Fly  2213 EPSQFSSQEEFMSEFGSLRTEEEVNKLQALLKPMMLRRLKDDVEKSLAPKEETIIEVELTNIQKK 2277

Frog  1004 YYRAILEKNFSFLTKGASQSNTPNLLNTMMELRKCCNHPYLITGAEEKIISEFREATPVVPPDFH 1068
            |||.|||:|||||.||.:.:|.|||:||||||||||.||||:.||||:|..:|:......|..::
  Fly  2278 YYRGILEQNFSFLKKGTTSANIPNLMNTMMELRKCCIHPYLLNGAEEQIQYDFKSQHGEDPESYY 2342

Frog  1069 VQAMVRSSGKLVLIDKLLPKLRAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNMRQ 1133
             :.::.|:||:||||||||||:|.||:||||||||||||||||||:.|:|.:||||||:|||:||
  Fly  2343 -KNLILSAGKMVLIDKLLPKLKANGHRVLIFSQMVRCLDILEDYLVYRKYPFERIDGRIRGNLRQ 2406

Frog  1134 AAIDRFSRPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKI 1198
            .||||:|:|.||||||||||:|||||||||||||.||:|||||||||||||||||||||.|.|||
  Fly  2407 EAIDRYSKPGSDRFVFLLCTKAGGLGINLTAADTVIIYDSDWNPQNDLQAQARCHRIGQRKMVKI 2471

Frog  1199 YRLITRNSYEREMFDKASLKLGLDKAVLQSMSGRDNHLSGPIQQFTKKEIEDLLRKGAYAAIMDE 1263
            |||:.||:||||||||||:||||||||||||:.:.:. .|..:|.:||||||||:||||.|:||:
  Fly  2472 YRLLCRNTYEREMFDKASMKLGLDKAVLQSMNTQGSK-DGNNKQLSKKEIEDLLKKGAYGAVMDD 2535

Frog  1264 DDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFSKASFVASENRTDISLDDPNFWQKWAKKADL 1328
            |:.|.||||||||.||.|||..||:||| ||||||||||.||.||:||::|||:||.|||||.|:
  Fly  2536 DNAGDKFCEEDIDSILKRRTQVITMESE-KGSTFSKASFAASGNRSDITIDDPDFWTKWAKKVDI 2599

Frog  1329 DLDLLSSKNT--LVIDTPRIRKQTRHFTNKDDDMVEFSDLESDDDD-----------RPKARRQD 1380
            |.|......|  ||:..||.|.|.:.:.:  :|::|.:..||.:::           |.:..::|
  Fly  2600 DPDACERDETEDLVLSEPRRRTQIKRYGH--EDVMELNSEESSNENSDEEGGIGLRSRRRKEKRD 2662

Frog  1381 R---KHG---------------------YG---RTDCFRVEKHLLVYGWGRWRDILTHGRFKRGM 1418
            |   |.|                     ||   :::||:|||.||.:|||||.::|..|:||||.
  Fly  2663 RAREKKGNDEYIPRERDALAALGLEEIQYGNWAKSECFKVEKGLLSFGWGRWSELLELGQFKRGW 2727

Frog  1419 NERDVEKICRAILVYCLLHYRGDENIKSFIWDLITPAENGKTKQL-QNHSGLSIPVPRGRKGKKV 1482
            .:.|||...|.||:|||..|:|||.||:||||||||.|:|:.::: ::||||...|||||.|.|.
  Fly  2728 RDVDVEDCARIILLYCLQVYKGDEKIKTFIWDLITPTEDGEVQKISRDHSGLHNLVPRGRNGGKS 2792

Frog  1483 KSQS------------------SFDIHKAD-----------------------------WI--HK 1498
            ..:|                  :...||:.                             |.  .|
  Fly  2793 NKESTGVSTPAPGSASGSNSGNTTPAHKSSALDGSDKDSGGINASAVAAAVTSIHDPNHWSKKEK 2857

Frog  1499 YNPDTLFQDEGYKKHLKHQCNKVLLRVRMLYFLRQEVIGNQAMKVLSGVEARQIDIWFPQVDQVE 1563
            |:.|. :.:..|||||....|||||||||||:::.||||:...::.......::.|..|.... :
  Fly  2858 YDADA-YLEGAYKKHLGRHANKVLLRVRMLYYIQHEVIGDFVQQIKDNTPISELPIRPPPTPD-Q 2920

Frog  1564 VPSRWWDRE-ADKSLLIGVFKHGYEKYNTMRADPALCFLEKVG---GPDEQAIA--------AEH 1616
            |||.||:.. .|||||:|.:|||.|.|..|||||.|||:..||   ..|:.|:.        |..
  Fly  2921 VPSSWWNPICCDKSLLVGTYKHGCEMYRQMRADPNLCFVTHVGAGAAGDDLAVTSLPINEDDANS 2985

Frog  1617 HAQDFSELPD---------------GGDFDRDIEDPEYKPLHAQK-------------------- 1646
            ...|..|:.|               |||....:.||| :|..:.|
  Fly  2986 KHDDGDEVDDDGTTTTKDSDSTKLTGGDNKDSLLDPE-RPSSSGKSSSENASGGNDKTESENDAT 3049

Frog  1647 --------------------------------------------------------DPED----- 1650
                                                                    ||.|
  Fly  3050 TVSESSYKSEVLPGKGSDLDVSVAQQDALSATPELANTSDPKMNKNDAQVSASVSCDPADSSSPE 3114

Frog  1651 ----------------EID---------------------------------------------- 1653
                            |:|
  Fly  3115 AAGKAQGTGVQTGDAGELDIESEKKDNEKETKESTGDAPAVEAKKDSAAIARAEGDKTESCTNNA 3179

Frog  1654 -----------------------------------------SLMMDEEISVVDG--------EEA 1669
                                                     .|.:|||.||...        |:|
  Fly  3180 TTNISTTTTTTTITNTTTTTNNPSSKAANSNNTTDHANSNSHLGLDEEESVAGSYPPTVAAVEDA 3244

Frog  1670 TAMPSGMLWPPGSALTARLRRLITAYQRSYKREQLKLE--------------------------- 1707
            |.|     ||....|..||||:||||||:||:|:|||:
  Fly  3245 TTM-----WPSMQDLNTRLRRVITAYQRNYKKEELKLQQKAKLQALVSSTPPLSVPTTPTLQSMQ 3304

Frog  1708 ---------------------------------------------AEERGD-------------- 1713
                                                         |...|.
  Fly  3305 MQLQSGSGSGGSGIGSSAQHDASGRSLQALMQSQGASTSAAAAAAASSAGGSCSGSGQVGMGGAG 3369

Frog  1714 ---------------------------------------------KRRKRCEAAFKLKEIARREK 1733
                                                         :|:.:.|.|.|.:|..|.:.
  Fly  3370 VMPAMPTAADISLMLSILNTTDVNQLANLDINKLAMYLVSMNNKMERQGKMELAAKERESQRLQL 3434

Frog  1734 -QQRWTRREACDFFRVLSSFGVEYDPDTQLY---------DWQRFRGLARLDKKTDESLLKYFHG 1788
             .::|.|||..:|.|||:.:||:....|.:.         ||.:|:.:|.|::|:||:|..|:..
  Fly  3435 IPKKWNRREEYEFLRVLTGYGVDLHVSTPMASSNGSSLSPDWTKFKQMAHLERKSDETLTDYYKV 3499

Frog  1789 FVAMCRQVCRLPPAAGDEPPDPSLFIEPISEERASRALFRLDLLRRVREQVLCHPLLIPRLSLCR 1853
            |||||::...|..:..:...:.  .||.|.:|.|...|.||::|.::|| |..:|:|..||.||.
  Fly  3500 FVAMCKRQAGLKLSESERGLEG--IIEEIEKEHAKLILDRLEVLAKLRE-VARNPMLEERLKLCT 3561

Frog  1854 PDPELPEWWESGRHDNELLQGAARYGLSRTDLTILQDHAFSF----------LRCQISYFQSRGI 1908
            .:.:.|:|||.||||.||:....::||.|::..|..|..|||          |..||    .|.|
  Fly  3562 KNADTPDWWEPGRHDKELITAVLKHGLYRSETFIFNDPNFSFGESEKRFIRELEAQI----QRTI 3622

Frog  1909 ------------------------SGHSRPSTPTTAPSVPTE---------------RQPSHLAS 1934
                                    :..:..:....|.||..|               ::.|.:..
  Fly  3623 KLEAFNAEKAEKLAAAEKDAATEKAAATEKAAAEKAASVKNEVIDLDDELMTNESVIKKESPVTP 3687

Frog  1935 LSSSVSCSPAPRRSSSCSSSSHSSNSED-SSDESNGVKVKP----NAGLSHARLYDEESRLSLTA 1994
            :...:....:|.:..:      :.|.|| :||.....|:|.    |...:.....||.:.|:
  Fly  3688 IKEEIKSEESPEKHDT------ADNLEDKNSDAEESTKIKGKEDFNPETTEKEALDESTNLN--- 3743

Frog  1995 SPADLTTEDSIQTALETPHSTDWPKDRVLICRIEQVCSAVLTGKWSSPRRLSDPP----SDSPDS 2055
              .|.::.:::...:|....::   |::   .:|::..|....|..||.:.||..    |:...|
  Fly  3744 --KDKSSTETLVPEIEDSKPSE---DKM---EVEELPVAENGEKEGSPEKCSDAEDKKFSEEKPS 3800

Frog  2056 LPPTPEQQSPAHFTQIRPAPDPKE----------------FTIQIKSEEG----LKIKFQKHKF- 2099
            .|..|:.: .:.......||:.:|                ...:::.|:|    .|.:.||.:.
  Fly  3801 SPAVPDGK-VSEMEADEAAPNTEENCSGDSESPEKECEDKVVEKVEEEKGENSYEKAEEQKEETE 3864

Frog  2100 -MGNGALDSAP-------------------------------------HTQKKKSK------KKM 2120
             :...:::|.|                                     ...|:|.|      ||.
  Fly  3865 KLEKSSIESEPSEKSETVLEPEVAVPKKSTGDQDILDLVAGPSDPDDDEVMKEKEKAVEEECKKQ 3929

Frog  2121 DLDMDTRIP---------VVNQKDGTLLLGEEAPLRCQLPEWLHRNPDFMVDPR---FIAFMEDR 2173
            ..::..|.|         |..||      .|:..|...:..|.   .||.::.|   .:|.:|..
  Fly  3930 AAELKARFPDLEVIQPATVKQQK------LEKPKLEMCMIRWF---KDFALERRIAHIVACVESG 3985

Frog  2174 R-----KRKKHRSKKSKSSSQIGNVQN-PHSHNGKKSSHTENSFE-------TQHLPTAAKKR-- 2223
            .     |.....:.|..:...|...:: ||..:.::.|.|.:...       |:||.|:..::
  Fly  3986 NWPVDSKYSAFATCKGATDLSIALHESIPHLSSLERRSTTPDVITITTDQGVTKHLQTSHMQQVA 4050

Frog  2224 ----------------KKRPPSKIIMPS--------------ALHGAGDVTHSFSDLQPDHSGHP 2258
                            :.:|.|...:|.              |...||....|.|.|.|   |..
  Fly  4051 SSASAASTSSGVPQVTQSKPSSSNSLPGLDAKSINAAVAAAVAAAAAGGNATSLSSLLP---GMS 4112

Frog  2259 MRSVYGPSDGGLSHQAGL------SGLGFTR--------------FHSSQTSSV----------- 2292
            :.:..|.|.||:|   ||      ||:|..|              .|:...||.
  Fly  4113 LSAATGSSAGGVS---GLSVPSAGSGVGKKRKRHIAIDVETERAKLHALLNSSTMAPKDWESEIA 4174

Frog  2293 ---------GRIHGTTFDELQSFEPP--QQHFSL-------LDDPMMPANSS---SSGDELD 2333
                     ||..|.........:||  .||.||       ...|.:||..:   |.|..:|
  Fly  4175 NMEALSGSSGRGRGGNSSASSGMQPPPAHQHASLSRQSSGQFSKPAVPAMKTPPPSMGAPMD 4236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
chd8	XP_012812626.1	Med15	35..>363	CDD:312941	77/396 (19%)
		CD1_tandem_CHD5-9_like	582..647	CDD:349315	35/276 (13%)
		CD2_tandem_CHD5-9_like	665..723	CDD:349310	35/57 (61%)
		PLN03142	754..>1357	CDD:215601	414/604 (69%)
		DEXHc_CHD8	755..976	CDD:350818	147/220 (67%)
		BRK	2123..2165	CDD:400080	10/50 (20%)
kis	NP_001137761.1	BASP1	1554..1786	CDD:283191	24/231 (10%)
		HepA	1676..2527	CDD:223627	428/852 (50%)
		SDA1	<1693..>1854	CDD:283052	0/160 (0%)
		CHROMO	<1879..1919	CDD:237991	24/39 (62%)
		Chromo	1941..1996	CDD:278797	34/54 (63%)
		DEXDc	2048..2197	CDD:238005	95/148 (64%)
		Helicase_C	2350..2464	CDD:278689	95/113 (84%)
		RR_TM4-6	3728..>3877	CDD:283990	27/160 (17%)
		BRK	4569..4613	CDD:197800
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	564	1.000	Domainoid score	I232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1491	1.000	Inparanoid score	I105
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001075
OrthoInspector	1	1.000	-	-		otm47615
Panther	1	1.100	-	-	O	PTHR45623
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3575
SonicParanoid	1	1.000	-	-		X648
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.090