DRSC/TRiP Functional Genomics Resources

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Protein Alignment btk and Src42A

DIOPT Version :9

Sequence 1:NP_001123732.1 Gene:btk / 100170477 XenbaseID:XB-GENE-6451230 Length:649 Species:Xenopus tropicalis
Sequence 2:NP_610191.2 Gene:Src42A / 35524 FlyBaseID:FBgn0264959 Length:1597 Species:Drosophila melanogaster


Alignment Length:670 Identity:205/670 - (30%)
Similarity:316/670 - (47%) Gaps:120/670 - (17%)


- Green bases have known domain annotations that are detailed below.


 Frog    14 KRSQQKRKTSPLNF-----KKRLFVLTDTKIIYYEYDFDRGR----------------RGSKKGS 57
            ||:|.||:....|.     .:.|:    |:||..:...|:..                |.:...|
  Fly   998 KRTQAKRRIGVTNLLLPLDSEELY----TRIIAQQRGLDKEHSQEPEEKCASEEQMCTRNALTKS 1058

 Frog    58 VDLDKVICVECVEPEENPPPERQIPNREEFDTEQMTIIERFPYPFQIVYDDGPLYVFAPTEELRK 122
            ..||.:.....:.|..:|.|.|  |.|   ..:|...:::        :...|         |.|
  Fly  1059 SSLDAISLSVAISPASSPSPPR--PRR---SLKQHRCLQQ--------HQQTP---------LAK 1101

 Frog   123 RWIHQLKHVIRFNSDVAQKYHPRFYQDGQYLCCAQTAKNAMGCQPLGNANGFIRTERSQRRSRKP 187
            :  |.|.:.::..|....:...|.:.:...|.|.        |.|        .||..       
  Fly  1102 K--HSLDNCLQVVSSTTSRQPLRRWSNQTPLKCT--------CHP--------ATEEL------- 1141

 Frog   188 LPPPPPQESQKPLP---PTPCLSLHKVVAMYDFTPLNAQDLPLHKGEEYVLLEEGTGNPWLRARD 249
              |....|..:.||   ...|......:::.|.:|...:..               |...|....
  Fly  1142 --PLTAIEKSRSLPAACSASCSHTCAHLSVIDQSPATTKCF---------------GKTSLTTAK 1189

 Frog   250 K---NGLEGYIPGNYVTEAQDPLEIYEWYSKNMTRSQAE-KLLRAEDKEGGFIVRDS-SKAGKYT 309
            |   ..|..:..|.::.|.       .||.:.:.|.:|| |||..|::.|.|::||| |:...|:
  Fly  1190 KGKSRRLSEFTRGEFLNEK-------SWYFRKIKRIEAEKKLLLPENEHGAFLIRDSESRHNDYS 1247

 Frog   310 VSVYAKSSGEGIIRHYVVCEAPGNQYYLAEKHLYSSIPELITYHQHNAAGLISRLKYPVCSLRKT 374
            :||   ..|: .::||.:.:.....:::|.:..:.::.||:.::..::.||...|..|...:.| 
  Fly  1248 LSV---RDGD-TVKHYRIRQLDEGGFFIARRTTFRTLQELVEHYSKDSDGLCVNLCKPCVQIEK- 1307

 Frog   375 APSTAGLGY---GSWEIDPKDLTFLKELGNGQFGVVKYGKWRGQHDVAIKMIKEGSMSEDEFIEE 436
             |.|.||.:   ..||||...|.|:::||:||||.|..|.|.....||||.:|.|:|...:|:.|
  Fly  1308 -PVTEGLSHRTRDQWEIDRTSLKFVRKLGSGQFGDVWEGLWNNTTPVAIKTLKSGTMDPKDFLAE 1371

 Frog   437 AKCMMKLSHQNLVQLYGVCTKQRPIFIITEFLSNGCLLNYLKDLRGR---VSQGDLLSMCSDVCA 498
            |:.|.||.|..|:|||.|||.:.||:||||.:.:|.||.||:.:.|:   :....|:.|.:.:.|
  Fly  1372 AQIMKKLRHTKLIQLYAVCTVEEPIYIITELMKHGSLLEYLQAIAGKGRSLKMQTLIDMAAQIAA 1436

 Frog   499 AMTYLESKQYLHRDLAARNCLVAADGIVKVSDFGLSRYVLDDEYTSSLGSKFPVRWSSPEVLLYC 563
            .|.||||:.|:||||||||.||....|||::||||:|.:.:|||.:.:|::||::|::||...|.
  Fly  1437 GMAYLESQNYIHRDLAARNVLVGDGNIVKIADFGLARLIKEDEYEARVGARFPIKWTAPEAANYS 1501

 Frog   564 RFSSKSDVWSFGVLMWEVFTLGRMPYDRFTNNEIVEQITRGVRLYRPQNATDRVYSIMVSCWAEK 628
            :||.||||||||:|:.|:.|.||:||...||.|::.|:..|.|:.:|.|...|:|.||:.||.:.
  Fly  1502 KFSIKSDVWSFGILLTELVTYGRIPYPGMTNAEVLTQVEHGYRMPQPPNCEPRLYEIMLECWHKD 1566

 Frog   629 ADDRPTFRILHNTILEVLED 648
            ...||||    .|:...|||
  Fly  1567 PMRRPTF----ETLQWKLED 1582

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btkNP_001123732.1 PH_Btk 8..167 CDD:269944 32/173 (18%)
SH3_BTK 209..264 CDD:212839 7/57 (12%)
SH2_Tec_Btk 267..370 CDD:198260 28/104 (27%)
PKc_like 388..638 CDD:419665 118/252 (47%)
Src42ANP_610191.2 SH2_Src_Src42 1210..1301 CDD:198233 27/94 (29%)
PTKc_Frk_like 1319..1587 CDD:270653 124/268 (46%)
Pkinase_Tyr 1328..1580 CDD:285015 117/255 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000006
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.910

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