DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PDCD6 and pdcd6

DIOPT Version :9

Sequence 1:	NP_037364.1	Gene:	PDCD6 / 10016	HGNCID:	8765	Length:	191	Species:	Homo sapiens
Sequence 2:	NP_001008004.1	Gene:	pdcd6 / 493366	XenbaseID:	XB-GENE-960916	Length:	184	Species:	Xenopus tropicalis

Alignment Length:	191	Identity:	155/191 - (81%)
Similarity:	171/191 - (89%)	Gaps:	7/191 - (3%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAYSYRPGPGAGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDTELQQALSNGTWTPFNPVTV 65
            ||.|..:..|       .|..:||||||||||||||:|||||||||||||||||||||||||.||
Frog     1 MAYYQQQNRP-------PGNTMPDQSFLWNVFQRVDRDRSGVISDTELQQALSNGTWTPFNPATV 58

Human    66 RSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQF 130
            .||||||||::|.||||:||:|||||||||||:||||||||||:|||||||||||||||||||||
Frog    59 NSIISMFDRDHKGGVNFNEFSGVWKYITDWQNIFRTYDRDNSGLIDKNELKQALSGFGYRLSDQF 123

Human   131 HDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV 191
            :|:||||||||.|||:|||||||.|||||||||:||||||||||||||||||||:|:||:|
Frog   124 YDVLIRKFDRQRRGQVAFDDFIQCCIVLQRLTDVFRRYDTDQDGWIQVSYEQYLTMIFSVV 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PDCD6	NP_037364.1	EFh_PEF_ALG-2	27..191	CDD:320058	145/163 (89%)
pdcd6	NP_001008004.1	EFh_PEF_ALG-2	20..184	CDD:320058	145/163 (89%)
		EF-hand motif	20..49	CDD:320058	27/28 (96%)
		EF-hand motif	57..86	CDD:320058	22/28 (79%)
		EF-hand motif	87..117	CDD:320058	27/29 (93%)
		EF-hand motif	123..152	CDD:320058	23/28 (82%)
		EF-hand motif	153..184	CDD:320058	27/30 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	109	1.000	Domainoid score	I28211
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7880
Inparanoid	1	1.050	318	1.000	Inparanoid score	I10347
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG54126
OrthoDB	1	1.010	-	-		D1330600at2759
OrthoFinder	1	1.000	-	-		FOG0000697
OrthoInspector	1	1.000	-	-		oto147959
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4200
SonicParanoid	1	1.000	-	-		X1327
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010