DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment si:dkey-22o22.2 and ds

DIOPT Version :9

Sequence 1:XP_001921123.3 Gene:si:dkey-22o22.2 / 100149950 ZFINID:ZDB-GENE-100922-84 Length:2780 Species:Danio rerio
Sequence 2:NP_001285551.1 Gene:ds / 33245 FlyBaseID:FBgn0284247 Length:3556 Species:Drosophila melanogaster


Alignment Length:2468 Identity:645/2468 - (26%)
Similarity:993/2468 - (40%) Gaps:530/2468 - (21%)


- Green bases have known domain annotations that are detailed below.


Zfish   120 VTVKIKMLQKDDETRRFNESSVSTGVIGVKSGSRKPRAVSEEVSYTVTVSEDVKVGDLIFTVPDQ 184
            :||.|.:...:|....||:|                       .|..||.|:..||..:..|...
  Fly   270 MTVNITIQDVNDNQPIFNQS-----------------------RYFATVPENATVGTSVLQVYAS 311

Zfish   185 KFEKKWFEVV--------SEGNSPIQMERDSGRVYL----------AHRLVSATEVMVKIHN--- 228
            ..:.....:|        |:.....:::..:|.:|:          .|.||    |:.|.|.   
  Fly   312 DTDADENGLVEYAINRRQSDKEQMFRIDPRTGAIYINKALDFETKELHELV----VVAKDHGEQP 372

Zfish   229 MRGDEWYLCRLTLTLPNMSNLQWAMFPYPYLAAVGPDTGAGSVVYKLVAQSPDGSVGTAHF-LLV 292
            :....:...|:|....|...:............:......|..|.::....||.....|:. :.:
  Fly   373 LETTAFVSIRVTDVNDNQPTINVIFLSDDASPKISESAQPGEFVARISVHDPDSKTEYANVNVTL 437

Zfish   293 DGGEDSFEVDQTTGEVKTTGRPLTPSKE----YTLTVQAVDSQGRRGTHASLFIL-----AGFRP 348
            :||:..|.:......:......|...:|    |||:|.|.| :|....|||..|.     ....|
  Fly   438 NGGDGHFALTTRDNSIYLVIVHLPLDREIVSNYTLSVVATD-KGTPPLHASKSIFLRITDVNDNP 501

Zfish   349 PQFTNTTYTIHIPESSAVGQAVAVVQAISFQR-----KTLSYMLLVNP---SNLFSINQESGALS 405
            |:|....|..::.|.:..|  .:|:|.::..|     ..|:|.|...|   :..|.|:.::|.::
  Fly   502 PEFEQDLYHANVMEVADPG--TSVLQVLAHDRDEGLNSALTYSLAETPETHAQWFQIDPQTGLIT 564

Zfish   406 LTRTVDYESGQHLHHLQVRASEPDTG---LSNMAEVVVHITDENDCTPEFMHSIYSRDNVPETTP 467
            ....:|.|: :.:..|.|.|.  |.|   ||:.|.|:|.|.|.||..|.|..|.|: .:|.|..|
  Fly   565 TRSHIDCET-EPVPQLTVVAR--DGGVPPLSSTATVLVTIHDVNDNEPIFDQSFYN-VSVAENEP 625

Zfish   468 TGTSLLQVLARDCDTGLNAELSY-----FIQSVDFDITS-QGVVSPSQRLDYERPNHMYECTVVA 526
            .|..:|:|.|.|.|.|:||.::|     |....:|::.| .|.:..:..||:|| ...||..|:|
  Fly   626 VGRCILKVSASDPDCGVNAMVNYTIGEGFKHLTEFEVRSASGEICIAGELDFER-RSSYEFPVLA 689

Zfish   527 VDKGTPPRTGTASIRIRMANVNDEAPVFSQTIYKTFL------SEDAGPETLVAIVHAKDPDGDG 585
            .|:|  ..:.||.|::::.:|||..|||....||..|      |..|....:||:| |.|||...
  Fly   690 TDRG--GLSTTAMIKMQLTDVNDNRPVFYPREYKVSLRESPKASSQASSTPIVAVV-ATDPDYGN 751

Zfish   586 ---VTYAITGGNEDSNFELDNQKGIIKLRRSPPPRLR-GPQYVLNVTATDDNAAGGALPLSSCAQ 646
               |:|.|..|||...|.:|...|.|.:.|.....:| .|.::||::|||    ||.|..::.|.
  Fly   752 FGQVSYRIVAGNEAGIFRIDRSTGEIFVVRPDMLSVRTQPMHMLNISATD----GGNLRSNADAV 812

Zfish   647 VIVGINDINNNKPVFDEC-HNYSVNALVLENQPPGTFVLRVQAHDADTGVNGEVKYGIMQRDGAS 710
            |.:.|.|.....|:|::. :||.|.    |:.|.||.|..|.|...|......|:|.|...|   
  Fly   813 VFLSIIDAMQRPPIFEKARYNYYVK----EDIPRGTVVGSVIAASGDVAHRSPVRYSIYSGD--- 870

Zfish   711 PG--FTINPDTGVISTAVSFDREKQREYTLSVTATDQAQEPLIGICQITVLIADQNDNDPKFENS 773
            |.  |:|..::|.|..|...|.|.:.:..|::.|| ..:.|:.|..|:.:.:.|.|||.|:||.|
  Fly   871 PDGYFSIETNSGNIRIAKPLDHEAKSQVLLNIQAT-LGEPPVYGHTQVNIEVEDVNDNAPEFEAS 934

Zfish   774 RYQYFLREDTPVGTSFLRAAAHDDDQGTNSAITYSL-SQQNPAYFHINPSTGWIYVNQPISQTSR 837
            ..:..:.|...:|.....|.|||.|.|::..:|||| .:.....|.|:..:|.:.::|.:...| 
  Fly   935 MVRISVPESAELGAPLYAAHAHDKDSGSSGQVTYSLVKESGKGLFAIDARSGHLILSQHLDYES- 998

Zfish   838 ISQQ----IIATDGGSRSSSVDLTVI--ITNVHNQPPQWEQAEYWVTIPENTPRDTKIVTIKATS 896
             ||:    :.|||||..|.|.:||::  :.:|::.||.:|:.||.|.:.|:...:.:|:.:.| |
  Fly   999 -SQRHTLIVTATDGGVPSLSTNLTILVDVQDVNDNPPVFEKDEYSVNVSESRSINAQIIQVNA-S 1061

Zfish   897 PL---GDPRVTYNLEE-------GQVPETNMPVRFYIKPNRRDGSASILVAENLDYETTGFFTLR 951
            .|   .:.|:||.:.:       ..:..:::...|.|.||    |..|.:...||.||...:.|.
  Fly  1062 DLDTGNNARITYRIVDAGVDNVTNSISSSDVSQHFGIFPN----SGWIYLRAPLDRETRDRYQLT 1122

Zfish   952 VRVQNVAAVPLASFTTVYVNITDVNDNVPFFMSSTYEATVPEGAEIGTSVAQVSATDLDSGLHGM 1016
            |...:.......:.|.|.|.:.|.|||.|.|..|.||..:.|....|:.|..|:|:|||.|.:..
  Fly  1123 VLATDNGTPAAHAKTRVIVRVLDANDNDPKFQKSKYEFRIEENLRRGSVVGVVTASDLDLGENAA 1187

Zfish  1017 INYIILKDQSGDSQFFSINSYTGIIHTRATFDREQKGSYLIEVQSQDSSESARPGQQGQP-NTDT 1080
            |.|.:|...|.    |.::..||.|.||...|||.:..|.:.|:::|         ||.| .:..
  Fly  1188 IRYSLLPINSS----FQVHPVTGEISTREPLDRELRELYDLVVEARD---------QGTPVRSAR 1239

Zfish  1081 AYVRVFVTDVNDNAPAFSQPVYE-ISVEEDKEVGFVVITVTANDEDEGANAKLRYQITSGNTM-- 1142
            ..||:.|:|||||||..:.|..: :||.|::..|..|:.|.|.|.|.|.||.:.|.|..|...  
  Fly  1240 VPVRIHVSDVNDNAPEIADPQEDVVSVREEQPPGTEVVRVRAVDRDHGQNASITYSIVKGRDSDG 1304

Zfish  1143 -GTFDVEPEVGTIFIAQRLDYEQVQRYELRLVASDG---KWENQTMVVINVINQNDEAPLFTQTE 1203
             |.|.::|..|.|.....||:|:...|.|.:.||||   ..|...|:.:.|::.||..|.||.:.
  Fly  1305 HGLFSIDPTSGVIRTRVVLDHEERSIYRLGVAASDGGNPPRETVRMLRVEVLDLNDNRPTFTSSS 1369

Zfish  1204 YHASVMEELT-----------ELPVLVLEVSATDPDQEADQRAVRYSLHGQGAG---SEFTIDEI 1254
            ....|.|:..           |.|..|:..|.   ::..:...|.|:|:.....   :.|.||..
  Fly  1370 LVFRVREDAALGHVVGSISPIERPADVVRNSV---EESFEDLRVTYTLNPLTKDLIEAAFDIDRH 1431

Zfish  1255 NGRIFAQRRLDREVRSAWQFLVLATDENGAG--LTGFADVLVDVQDINDNAPVFLCATDNCFLGH 1317
            :|.:...|.|||||:|.::..:.|.|...:.  .:....|.::|.|:|||||.:  ..|...| .
  Fly  1432 SGNLVVARLLDREVQSEFRLEIRALDTTASNNPQSSAITVKIEVADVNDNAPEW--PQDPIDL-Q 1493

Zfish  1318 VPENSPADTSIMEMRATDLDDPKAGKNAILTYRIVQ-----NVRNEINLNLFSINPTTGTIYTVL 1377
            |.|.:|..|.|....|||.|   .|.|..|.||:::     |...|..::||.::..||.: ::.
  Fly  1494 VSEATPVGTIIHNFTATDAD---TGTNGDLQYRLIRYFPQLNESQEQAMSLFRMDSLTGAL-SLQ 1554

Zfish  1378 RSLDREVVDRYLVVVEARDGGG-----LSGTGTATIVISDVNDHPPVFTQ------RVYMASMSE 1431
            ..||.|.|..||::|:|.|...     |..:.|..:.|.|.|||.|.|..      :.....:|:
  Fly  1555 APLDFEAVQEYLLIVQALDQSSNVTERLQTSVTVRLRILDANDHAPHFVSPNSSGGKTASLFISD 1619

Zfish  1432 NLDINSEVMVVAATDGDEGENSVMTFSIIGGDEDRKFFIETDKVNRRGIVRLKKKI-----DFEK 1491
            ...|...|..:.|.|.|.|:|..:|:.|.||:.:.:|.|.    ::.||:.|.|.:     |.||
  Fly  1620 ATRIGEVVAHIVAVDEDSGDNGQLTYEITGGNGEGRFRIN----SQTGIIELVKSLPPATEDVEK 1680

Zfish  1492 PHERTFNLTVKVED-----ADFFSLAYCIIQVEDSNDHTPVFFPQFYEAGSMFEDVPVGTIVAQV 1551
            ...  |||.:..:|     ....||...:| |:.|:::.|.|....|.| ::.|:||.|:.|.||
  Fly  1681 GGR--FNLIIGAKDHGQPEPKKSSLNLHLI-VQGSHNNPPRFLQAVYRA-TILENVPSGSFVLQV 1741

Zfish  1552 TAMDLDSGQNGRFTYSIAPESDPFQQFLVD-KSGWVVVADSLDREKVAQHRLMILATDMG-SPAL 1614
            ||..|...:|...:|.| |.......|.|| :.|.:......|||..|.:.|.:...|.. ...|
  Fly  1742 TAKSLHGAENANLSYEI-PAGVANDLFHVDWQRGIITTRGQFDRESQASYVLPVYVRDANRQSTL 1805

Zfish  1615 TGSAI----------------------VLVTVQDVNDNGPEFE--APYRPIVWENTIAPQVIHMN 1655
            :.||:                      :.:||.|||||.|||.  :.|...|.||: .|.|||  
  Fly  1806 SSSAVRKQRSSDSIGDTSNGQHFDVATIYITVGDVNDNSPEFRPGSCYGLSVPENS-EPGVIH-- 1867

Zfish  1656 DTSTLLHAIDRDTSSNGGPFSIRLLMLTSDVTNFNLTD---MRNGSAMITALRSFDREQQKQYLL 1717
               |:: |.|.|...|..        |...:|..||.:   :.:.|..::| |..||||..:|.|
  Fly  1868 ---TVV-ASDLDEGPNAD--------LIYSITGGNLGNKFSIDSSSGELSA-RPLDREQHSRYTL 1919

Zfish  1718 PILMIDSGSP-PMSSTSTLTVIIGDKNDHPHAPGHSEFIVYNIQGT------LPTTVLGQVQSPD 1775
            .|...|.|.| .......:|:.:.|:||  :||   .|.:....|:      |.|:|: |:.:.|
  Fly  1920 QIQASDRGQPKSRQGHCNITIFVEDQND--NAP---RFKLSKYTGSVQEDAPLGTSVV-QISAVD 1978

Zfish  1776 LDDW--SEKVYKFEGKPPRQFILNQNNGQLSVREGTAAGLYSLQVRVADKSWPDVTSSAEVTVME 1838
            .|..  :..||....:...||.::..:|.::                              ||.:
  Fly  1979 ADLGVNARLVYSLANETQWQFAIDGQSGLIT------------------------------TVGK 2013

Zfish  1839 LQEEALRNAASIRLANLTANEFFRASANEESRYMRLRRLLSELFQTDVENVDVFSLASGRQPAQH 1903
            |..|            |.|:..|...|.:..||                     .:.|...|.| 
  Fly  2014 LDRE------------LQASYNFMVLATDGGRY---------------------EVRSATVPVQ- 2044

Zfish  1904 HLSVWFAAHGSPYYKPEKLHGYIAMHKAKLESALGVTILQVGVDECVYAACGQTGGCSSKVTFSD 1968
             ::|.......|.:   :.:.||....|.::.  |.|:|:|       .|.....|.::::.:| 
  Fly  2045 -INVLDINDNRPIF---ERYPYIGQVPALIQP--GQTLLKV-------QALDADLGANAEIVYS- 2095

Zfish  1969 TPTTLNNGNISLVSVSAKASVQCGCLGRESVHLHCSSYSQSPCLNGGTCVDSELGYRCKCPPMFD 2033
                ||..| |.||...:.:...|.|          |.|||.....|..:..|:..|.|..|   
  Fly  2096 ----LNAEN-SAVSAKFRINPSTGAL----------SASQSLASESGKLLHLEVVARDKGNP--- 2142

Zfish  2034 GPECQQTKHSFLGNGYAWFHPIKPCFQSHISLEFITEAANGLLFYNGPMGAPQPREKEDFIALEL 2098
             |:      |.||                     :.|    ||....|.|.|..|.:.:...:.|
  Fly  2143 -PQ------SSLG---------------------LIE----LLIGEAPQGTPVLRFQNETYRVML 2175

Zfish  2099 KNGVPVLSVNHGSGTLTLQLSARATVTDRRWHHLDIISDGK--SVQ-----------MILDHCSG 2150
            |...|       |||..||:.|             :.|||:  .||           :.||..||
  Fly  2176 KENSP-------SGTRLLQVVA-------------LRSDGRRQKVQFSFGAGNEDGILSLDSLSG 2220

Zfish  2151 AV-VNEVEGLGVEMFET--------------DQSVCKASGETPG----SERFLDVYQPLQLGGVK 2196
            .: ||:...|..:.|.|              ::.:.::|.|.|.    |:|.|          ..
  Fly  2221 EIRVNKPHLLDYDRFSTPSMSALSRGRALHYEEEIDESSEEDPNNSTRSQRAL----------TS 2275

Zfish  2197 ETHSLRRSHPHY-----------KGFVGCMRNLVVDSQVYDLSSAAESEN-TAPGCALTDGVCLT 2249
            .:.:|..|.|:.           ..|:.....||::         .|.|| .:|..:....|...
  Fly  2276 SSFALTNSQPNEIRVVLVARTADAPFLASYAELVIE---------LEDENDNSPKFSQKQFVATV 2331

Zfish  2250 AGGPSCGVHGRCLGEWGSFSCDCHPGYSGHKCDKALPEWSFERD----SVLRYQLRGGGSPRRTQ 2310
            :.|          ...|:|....|               :|:.|    :.|||.:..|.....  
  Fly  2332 SEG----------NNKGTFVAQVH---------------AFDSDAGSNARLRYHIVDGNHDNA-- 2369

Zfish  2311 AHFLLRTRSS----TGTLLSMASRDANEFIILEIVDGYLNVRANLGDGTHSLKLTGQRVNHGQ 2369
              |::....|    |..:|....||..:..|:...:|...:     .||.::::....||..|
  Fly  2370 --FVIEPAFSGIVRTNIVLDREIRDIYKLKIIATDEGVPQM-----TGTATIRVQIVDVNDNQ 2425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
si:dkey-22o22.2XP_001921123.3 Cadherin_repeat 257..360 CDD:206637 25/112 (22%)
Cadherin_repeat 355..447 CDD:206637 27/102 (26%)
Cadherin_repeat 461..549 CDD:206637 31/93 (33%)
Cadherin_repeat 558..657 CDD:206637 37/108 (34%)
Cadherin_repeat 668..766 CDD:206637 29/99 (29%)
Cadherin_repeat 775..863 CDD:206637 28/94 (30%)
Cadherin_repeat 874..978 CDD:206637 28/113 (25%)
Cadherin_repeat 986..1093 CDD:206637 36/107 (34%)
Cadherin_repeat 1101..1194 CDD:206637 32/99 (32%)
Cadherin_repeat 1203..1302 CDD:206637 26/114 (23%)
Cadherin_repeat 1317..1416 CDD:206637 34/108 (31%)
Cadherin_repeat 1424..1524 CDD:206637 30/109 (28%)
Cadherin_repeat 1533..1630 CDD:206637 34/120 (28%)
Cadherin_repeat 1637..1745 CDD:206637 33/111 (30%)
Cadherin_repeat 1756..1836 CDD:206637 12/87 (14%)
EGF_CA 2003..2038 CDD:238011 10/34 (29%)
LamG 2062..2223 CDD:214598 42/203 (21%)
EGF_CA 2247..2281 CDD:238011 4/33 (12%)
Laminin_G_2 2315..2438 CDD:280389 12/59 (20%)
EGF_CA 2512..2544 CDD:238011
Cadherin_C 2602..2758 CDD:279398
dsNP_001285551.1 CA 111..172 CDD:214520
Cadherin_repeat 178..282 CDD:206637 3/11 (27%)
Cadherin_repeat 291..389 CDD:206637 19/101 (19%)
Cadherin_repeat 406..500 CDD:206637 21/94 (22%)
Cadherin_repeat 509..607 CDD:206637 28/102 (27%)
Cadherin_repeat 616..711 CDD:206637 33/98 (34%)
Cadherin_repeat 719..820 CDD:206637 36/105 (34%)
Cadherin_repeat 832..927 CDD:206637 31/102 (30%)
Cadherin_repeat 937..1032 CDD:206637 29/96 (30%)
Cadherin_repeat 1040..1149 CDD:206637 28/113 (25%)
Cadherin_repeat 1158..1252 CDD:206637 36/106 (34%)
Cadherin_repeat 1263..1361 CDD:206637 33/97 (34%)
Cadherin_repeat 1369..1481 CDD:206637 26/114 (23%)
Cadherin_repeat 1489..1598 CDD:206637 35/113 (31%)
Cadherin_repeat 1614..1710 CDD:206637 28/102 (27%)
Cadherin_repeat 1723..1843 CDD:206637 34/121 (28%)
Cadherin_repeat 1853..1948 CDD:206637 34/112 (30%)
Cadherin_repeat 1957..2053 CDD:206637 26/161 (16%)
Cadherin_repeat 2061..2154 CDD:206637 33/152 (22%)
Cadherin_repeat 2170..2318 CDD:206637 38/186 (20%)
Cadherin_repeat 2326..2424 CDD:206637 23/131 (18%)
Cadherin_repeat 2434..2528 CDD:206637
Cadherin_repeat 2549..2641 CDD:206637
Cadherin_repeat 2652..2748 CDD:206637
Cadherin_repeat 2758..2858 CDD:206637
Cadherin_repeat 2866..2960 CDD:206637
Cadherin_repeat 2985..3071 CDD:206637
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100175
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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