Protein Alignment nox5 and Duox

DIOPT Version :10

• Sequence 1: XP_017209809.2
• Gene: nox5 / 100149800
• ZFINID: ZDB-GENE-091120-9
• Length: 775
• Species: Danio rerio
• Sequence 2: NP_608715.2
• Gene: Duox / 33477
• FlyBaseID: FBgn0283531
• Length: 1537
• Species: Drosophila melanogaster
• Alignment Length: 817
• Identity: 202/817 - (24%)
• Similarity: 341/817 - (41%)
• Gaps: 198/817 - (24%)

Zfish    31 EFKTALKVK-ESFFAERFFALFDSDGSSSISLDELLKALDLLIHGTETDKLRFLFQVYDVDGSGS 94
            ||..||.:| ...|..:.|.:.|.|....||..|.|:.:.|...|...||||.:|.:.|.|.:|.
  Fly   846 EFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGV 910

Zfish    95 IDPDELRTVLKSCLR-ESAISLPEEKLDDLTLALFESADKDNSGSITFEELKAEL---------- 148
            ||..||..:::|.:. ....||.::::.:|...:|:....::...:|:::.|..:
  Fly   911 IDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAI 975

Zfish   149 --------ETFPEVMENLTISAANWLKPPDLEQNKRKTPRYLTRAYW-------HNNSRKLFFLC 198
                    :.|.:...|:....:..::|   .|:|   ||:...|.|       ..|.:.:|:|.
  Fly   976 GLDCKGAKQNFLDTSTNVARMTSFNIEP---MQDK---PRHWLLAKWDAYITFLEENRQNIFYLF 1034

Zfish   199 LYGLLNTFLFI------MAMLKHAD----GGLWIMLARGCGQCLNLNCTFVMVLMLRRCLTWLRA 253
            |:.::...||:      ..|.:|.|    .|:.|.:.||....|:...:.:::.|.|..:|.|:.
  Fly  1035 LFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKE 1099

Zfish   254 TWVVRVLPLDQNILLHQIVGYAILIFSVGHTGAHIMNFARLSQNDGAYQLWEYLFTI-------- 310
            ..:.:.:|||.:|..|:|.....|.|||.||..||:||..:|.     |..|.|..:
  Fly  1100 FPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVST-----QSHENLRCLTREVHFAS 1159

Zfish   311 --RPGIG-W----VNGTASITGVVIQILIGLMVVCSSTFVRRSGHFEVFYWS-HLSYIWVWALLV 367
              :|.|. |    |.||   |||::.|::.::.|.:...:|:..:  .|:|: |..||.::.|.:
  Fly  1160 DYKPDITFWLFQTVTGT---TGVMLFIIMCIIFVFAHPTIRKKAY--NFFWNMHTLYIGLYLLSL 1219

Zfish   368 VH-------CANFWKWFVVPGVAFLIEKLVGIAVSRMGGLYIVEVNLLPSKVTHLVIKRPPFFQF 425
            :|       ...||.:|:.||:.:.::|:|.:....| .|.:::.:||||.|..:...|||..::
  Fly  1220 IHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYM-ALDVIDTDLLPSDVIKIKFYRPPNLKY 1283

Zfish   426 KPGDYVYINIPTIAKYEWHPFTISSAPEQQETLWLHIRSMGQWTNRLYEYFRQPDTQTNKRLTAS 490
            ..|.:|.::......:|.|.||::||| .:..|..||::.|.||.:|..|| .|
  Fly  1284 LSGQWVRLSCTAFRPHEMHSFTLTSAP-HENFLSCHIKAQGPWTWKLRNYF-DP----------- 1335

Zfish   491 LRSRRHQSRAQEEMFRSASCRGSVASNKDDAVELTMYRTNGTRRNSQNPVCDPAAQAELGDASLA 555
                               |                         :.||...|
  Fly  1336 -------------------C-------------------------NYNPEDQP------------ 1344

Zfish   556 TRELTAKLSENHRYCNIKCYVDGPFGTPTRQIFASEHAILIGAGIGITPFASILQSIMCRYRMRK 620
                             |..::||||...:..:..|.|:::|.|||:||:||||..::......:
  Fly  1345 -----------------KIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNR 1392

Zfish   621 QNCPNCSYSWCETIKDNEMKLRKVDFIWINRDQKSFEWFVSLLTKLEMDQADEEPEGRFLEMHMY 685
            .:...|               :||.|:||....|.||||:.:|..:|     ::.....||:|::
  Fly  1393 YSGVAC---------------KKVYFLWICPSHKHFEWFIDVLRDVE-----KKDVTNVLEIHIF 1437

Zfish   686 MTSALSKNDMKAIGLQMALDLLAKKEKRDSITGLRTRTQPGRPDWAKVFQKVSEEKK---GKVHV 747
            :|....|.|::...|.:..:...:..|....|||:.....||||.:. |.|..::|.   .|:.|
  Fly  1438 ITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSS-FLKFVQKKHSYVSKIGV 1501

Zfish   748 FYCGSPALAKVIKAQCER---------FGFHFYKENF 775
            |.||...|.|.:.:.|:.         |..||  |||
  Fly  1502 FSCGPRPLTKSVMSACDEVNKTRKLPYFIHHF--ENF 1536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
nox5	XP_017209809.2	None
Duox	NP_608715.2	dual_peroxidase_like	72..625	CDD:188652
		PTZ00184	807..965	CDD:185504	34/118 (29%)
		EFh	860..921	CDD:238008	21/60 (35%)
		PLN02844	<1081..>1393	CDD:215453	100/408 (25%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	91/379 (24%)