DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nox5 and Duox

DIOPT Version :9

Sequence 1:	XP_017209809.1	Gene:	nox5 / 100149800	ZFINID:	ZDB-GENE-091120-9	Length:	775	Species:	Danio rerio
Sequence 2:	NP_001259968.1	Gene:	Duox / 33477	FlyBaseID:	FBgn0283531	Length:	1537	Species:	Drosophila melanogaster

Alignment Length:	817	Identity:	202/817 - (24%)
Similarity:	340/817 - (41%)	Gaps:	198/817 - (24%)

- Green bases have known domain annotations that are detailed below.

Zfish    31 EFKTALKVK-ESFFAERFFALFDSDGSSSISLDELLKALDLLIHGTETDKLRFLFQVYDVDGSGS 94
            ||..||.:| ...|..:.|.:.|.|....||..|.|:.:.|...|...||||.:|.:.|.|.:|.
  Fly   846 EFAAALGMKPNDMFVRKMFNIVDKDQDGRISFQEFLETVVLFSRGKTDDKLRIIFDMCDNDRNGV 910

Zfish    95 IDPDELRTVLKSCLR-ESAISLPEEKLDDLTLALFESADKDNSGSITFEELKAEL---------- 148
            ||..||..:::|.:. ....||.::::.:|...:|:....::...:|:::.|..:
  Fly   911 IDKGELSEMMRSLVEIARTTSLGDDQVTELIDGMFQDVGLEHKNHLTYQDFKLMMKEYKGDFVAI 975

Zfish   149 --------ETFPEVMENLTISAANWLKPPDLEQNKRKTPRYLTRAYW-------HNNSRKLFFLC 198
                    :.|.:...|:....:..::|   .|:|   ||:...|.|       ..|.:.:|:|.
  Fly   976 GLDCKGAKQNFLDTSTNVARMTSFNIEP---MQDK---PRHWLLAKWDAYITFLEENRQNIFYLF 1034

Zfish   199 LYGLLNTFLFI------MAMLKHAD----GGLWIMLARGCGQCLNLNCTFVMVLMLRRCLTWLRA 253
            |:.::...||:      ..|.:|.|    .|:.|.:.||....|:...:.:::.|.|..:|.|:.
  Fly  1035 LFYVVTIVLFVERFIHYSFMAEHTDLRHIMGVGIAITRGSAASLSFCYSLLLLTMSRNLITKLKE 1099

Zfish   254 TWVVRVLPLDQNILLHQIVGYAILIFSVGHTGAHIMNFARLSQNDGAYQLWEYLFTI-------- 310
            ..:.:.:|||.:|..|:|.....|.|||.||..||:||..:|.     |..|.|..:
  Fly  1100 FPIQQYIPLDSHIQFHKIAACTALFFSVLHTVGHIVNFYHVST-----QSHENLRCLTREVHFAS 1159

Zfish   311 --RPGIG-W----VNGTASITGVVIQILIGLMVVCSSTFVRRSGHFEVFYWS-HLSYIWVSALLV 367
              :|.|. |    |.||   |||::.|::.::.|.:...:|:..:  .|:|: |..||.:..|.:
  Fly  1160 DYKPDITFWLFQTVTGT---TGVMLFIIMCIIFVFAHPTIRKKAY--NFFWNMHTLYIGLYLLSL 1219

Zfish   368 VH-------CANFWKWFVVPGVAFLIEKLVGIAVSRMGGLYIVEVNLLPSKVTHLVIKRPPFFQF 425
            :|       ...||.:|:.||:.:.::|:|.:....| .|.:::.:||||.|..:...|||..::
  Fly  1220 IHGLARLTGPPRFWMFFLGPGIVYTLDKIVSLRTKYM-ALDVIDTDLLPSDVIKIKFYRPPNLKY 1283

Zfish   426 KPGDYVYINIPTIAKYEWHPFTISSAPEQQETLWLHIRSMGQWTNRLYEYFRQPDTQTNKRLTAS 490
            ..|.:|.::......:|.|.||::||| .:..|..||::.|.||.:|..|| .|
  Fly  1284 LSGQWVRLSCTAFRPHEMHSFTLTSAP-HENFLSCHIKAQGPWTWKLRNYF-DP----------- 1335

Zfish   491 LRSRRHQSRAQEEMFRSASCRGSVASNKDDAVELTMYRTNGTRRNSQNPVCDPAAQAELGDASLA 555
                               |                         :.||...|
  Fly  1336 -------------------C-------------------------NYNPEDQP------------ 1344

Zfish   556 TRELTAKLSENHRYCNIKCYVDGPFGTPTRQIFASEHAILIGAGIGITPFASILQSIMCRYRMRK 620
                             |..::||||...:..:..|.|:::|.|||:||:||||..::......:
  Fly  1345 -----------------KIRIEGPFGGGNQDWYKFEVAVMVGGGIGVTPYASILNDLVFGTSTNR 1392

Zfish   621 QNCPNCSYSWCETIKDNEMKLRKVDFIWINRDQKSFEWFVSLLTKLEMDQADEEPEGRFLEMHMY 685
            .:...|               :||.|:||....|.||||:.:|..:|     ::.....||:|::
  Fly  1393 YSGVAC---------------KKVYFLWICPSHKHFEWFIDVLRDVE-----KKDVTNVLEIHIF 1437

Zfish   686 MTSALSKNDMKAIGLQMALDLLAKKEKRDSITGLRTRTQPGRPDWAKVFQKVSEEKK---GKVHV 747
            :|....|.|::...|.:..:...:..|....|||:.....||||.:. |.|..::|.   .|:.|
  Fly  1438 ITQFFHKFDLRTTMLYICENHFQRLSKTSIFTGLKAVNHFGRPDMSS-FLKFVQKKHSYVSKIGV 1501

Zfish   748 FYCGSPALAKVIKAQCER---------FGFHFYKENF 775
            |.||...|.|.:.:.|:.         |..||  |||
  Fly  1502 FSCGPRPLTKSVMSACDEVNKTRKLPYFIHHF--ENF 1536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nox5	XP_017209809.1	EFh	44..105	CDD:238008	21/60 (35%)
		EF-hand_7	44..100	CDD:290234	19/55 (35%)
		EFh	79..146	CDD:238008	17/67 (25%)
		EF-hand_7	80..146	CDD:290234	16/66 (24%)
		Ferric_reduct	231..366	CDD:280043	42/150 (28%)
		NOX_Duox_like_FAD_NADP	402..775	CDD:99783	91/384 (24%)
Duox	NP_001259968.1	An_peroxidase	70..580	CDD:281139
		dual_peroxidase_like	72..625	CDD:188652
		EFh	827..882	CDD:238008	12/35 (34%)
		EFh	860..921	CDD:238008	21/60 (35%)
		EF-hand_7	860..920	CDD:290234	21/59 (36%)
		EFh	895..966	CDD:238008	18/70 (26%)
		EF-hand_7	899..965	CDD:290234	15/65 (23%)
		Ferric_reduct	1084..1217	CDD:280043	41/142 (29%)
		NOX_Duox_like_FAD_NADP	1265..1536	CDD:99783	91/379 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0039
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810