DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment il1rapl2 and CG45263

DIOPT Version :9

Sequence 1:	NP_001136056.1	Gene:	il1rapl2 / 100149452	ZFINID:	ZDB-GENE-040219-5	Length:	681	Species:	Danio rerio
Sequence 2:	NP_731246.2	Gene:	CG45263 / 50003	FlyBaseID:	FBgn0266801	Length:	1876	Species:	Drosophila melanogaster

Alignment Length:	701	Identity:	147/701 - (20%)
Similarity:	231/701 - (32%)	Gaps:	204/701 - (29%)

- Green bases have known domain annotations that are detailed below.

Zfish    45 AGEPLRVKCALFYSYIRTNYSVAQNAKLRLIWYRNKGDSE-EPIIFSGHRLSKEGDSIWFR---- 104
            ||....|||...|.          |....|.|:  .||.| .||....:....:....|..
  Fly   194 AGALATVKCISHYG----------NPPATLKWF--LGDQEISPIHPQMNATEPDNPRTWSATSVV 246

Zfish   105 --SAEMEDNGFYTCVLRNSTYCMKVSMSLTVEESEEGLCFSSRIRYQERAEITKSKMISCPDID- 166
              ||..|.:|   .:||.:.|....:....|.|:...:.::..||           :|..|:||
  Fly   247 QVSAMRERHG---DILRCAAYHESYTAKSVVVEARLDVKYAPSIR-----------LIGSPEIDL 297

Zfish   167 ----DYL-----APYKQPI-MTWYKECQRKEWRSSIIINTTSLWIPEVQEDDGGNYTCELKYGSK 221
                |.|     |....|. :.|     |:..||.|.....:|.:..|...|.|.|||:   ...
  Fly   298 EEDKDALVLRCVADANPPASIVW-----RRAGRSEIASLQETLQLRPVGRRDAGLYTCQ---AQN 354

Zfish   222 VVRRTTELKVTALLTTRPPKVLFPSERQASVIDVQLGMRLILDCKAFFGYSGDSKPIIYWMK--- 283
            .|..:.:|.| .|....|||::  |.....:....|......:|.|    .|:..|...|::
  Fly   355 SVGTSEQLSV-QLDVKYPPKII--SAGPDRLTTAPLFSPAAFECLA----DGNPLPSFKWVQRMA 412

Zfish   284 -GDKFVEELEGHIRESEVRVVREFLGEKEVELSLVFDAVEDTDMGNYTCNVENHIGRGSGSAILQ 347
             |.|:||      |.||.|              ||.|.|.....|.|.|...::|   :|...:.
  Fly   413 HGSKYVE------RGSESR--------------LVIDNVTYEYQGEYECRATSYI---NGQERVA 454

Zfish   348 KKDMYRLELVGGLGAIMLLLGIFTAIYK---CYNVEIMLC-------YRQHFGSDEADDGNKEYD 402
            ..|...|::||....:.|...:.|...|   ..::.:::|       ....:||...:.|:
  Fly   455 ISDPVSLQVVGAPQVLRLHPSLHTVSVKRGEAASLTMVVCADPRPQRVAWEWGSLRLEAGS---- 515

Zfish   403 AYLSYTKVDLDSVEQEMSEEEQFALEILPDVLEKHYGYKLFIPHRDLIPSSTYIEDLARSVEQSR 467
                       .:::..:::.|      ||..|..|...|.|.|.|...|..|...:.......|
  Fly   516 -----------GIDRFRADDMQ------PDTREDCYLSTLHILHADEHDSRPYYLVVENERGTDR 563

Zfish   468 RLIIVLTPEFVARRGWSIFQFEPRLHSML--VTG--EIKVIMIECPDLRSV----------INYQ 518
            ..|.::.....|         ||...|.|  |.|  ...::::.|..:.::          ..|:
  Fly   564 HAIHLIVEGTFA---------EPYEMSYLMGVAGGCMAAILLLVCLCIYAIKSKRCCFKGSTGYK 619

Zfish   519 ------EVEDLKHTIRVLTLIKWQGPKSNQLKSKFWKQVRYEMPA-----KKKETMSRRQVLDSG 572
                  |..|||....     ...||:.:.:         |..||     ::::...::|
  Fly   620 SSDKDSEKADLKSRSD-----STSGPQGDSI---------YTTPAGFHHHQQQQQQQQQQ----- 665

Zfish   573 EQGLFGDLQAVSTVAMTATSASLAPTQVEIPDYNEPSHMQMRHFCRSYEYELPT---TAIATLNG 634
                    |..:..|..|..|:....|.:.|.:..|..|::|  ..:...:.||   .||.|.:.
  Fly   666 --------QHAAAAAAAALHAASQHPQQQYPGHGSPEAMKVR--MAAMILQPPTRVXQAIDTTSE 720

Zfish   635 RHMYCNLPMTLLNGRLTQ-----NNIGKGKKE-IHLNSSFVPLSGQELSSD 679
            .           |.:|||     :|..|.|.| .|.|.    |:.|..:|:
  Fly   721 S-----------NEQLTQQQQQDDNKNKNKNENEHQNE----LTDQHTTSN 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
il1rapl2	NP_001136056.1	Ig	32..133	CDD:299845	22/94 (23%)
		IG_like	39..133	CDD:214653	22/94 (23%)
		Ig	146..232	CDD:299845	24/96 (25%)
		IG_like	160..231	CDD:214653	22/81 (27%)
		I-set	247..347	CDD:254352	23/103 (22%)
		Ig	253..347	CDD:299845	23/97 (24%)
		TIR	400..558	CDD:214587	31/182 (17%)
CG45263	NP_731246.2	I-set	53..149	CDD:254352
		Ig	198..281	CDD:299845	22/97 (23%)
		IG_like	302..368	CDD:214653	20/74 (27%)
		IGc2	302..357	CDD:197706	16/62 (26%)
		Ig	372..446	CDD:299845	24/99 (24%)
		Ig	475..568	CDD:299845	19/113 (17%)
		IG_like	478..570	CDD:214653	19/112 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910