DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf128 and RNF128

DIOPT Version :9

Sequence 1:	XP_012824820.2	Gene:	rnf128 / 100145171	XenbaseID:	XB-GENE-877067	Length:	403	Species:	Xenopus tropicalis
Sequence 2:	NP_919445.1	Gene:	RNF128 / 79589	HGNCID:	21153	Length:	428	Species:	Homo sapiens

Alignment Length:	394	Identity:	236/394 - (59%)
Similarity:	295/394 - (74%)	Gaps:	21/394 - (5%)

- Green bases have known domain annotations that are detailed below.

Frog    28 GADTLWTANVNYSYVYD----NRTYGEEGEIGVFGQDSPIERAAGLVVLPKSERTFTACKDNTNF 88
            ||:.:|||.:|.|:...    |||..|..|.||:|||||:|..||::|.|.......||..:|||
Human    38 GAEAVWTAYLNVSWRVPHTGVNRTVWELSEEGVYGQDSPLEPVAGVLVPPDGPGALNACNPHTNF 102

Frog    89 SVPHNWNG----PWIALILRGGGCTFTEKINRAAERGARAVVVYN-NGMDNEVFEMSHPGTKDTV 148
            :||..|..    .|:|||.|||||||.:||:.|.||||...|::| .|..|||..|||||..|.|
Human   103 TVPTVWGSTVQVSWLALIQRGGGCTFADKIHLAYERGASGAVIFNFPGTRNEVIPMSHPGAVDIV 167

Frog   149 AIMIGNIKGNEIVEVIKGGMQVMMVIEVGRKHGSWINHYSIFFVSVSFFIVTAATVGYFIFYSAR 213
            ||||||:||.:|::.|:.|:||.||||||:|||.|:||||||||||||||:||||||||||||||
Human   168 AIMIGNLKGTKILQSIQRGIQVTMVIEVGKKHGPWVNHYSIFFVSVSFFIITAATVGYFIFYSAR 232

Frog   214 RWRLTRAQNKKMKQLKAEAKKAIGKLQLRTIKQGDKVLGPDGDSCAVCIEPYKPSDVVRILTCNH 278
            |.|..|||::|.:||||:||||||:|||||:|||||.:||||||||||||.|||:|:||||||||
Human   233 RLRNARAQSRKQRQLKADAKKAIGRLQLRTLKQGDKEIGPDGDSCAVCIELYKPNDLVRILTCNH 297

Frog   279 FFHKNCIDPWLLEHRTCPMCKCDILKSLGIAED-EEETTSAAIPSVSSELQRSTVQTIEEENRSE 342
            .|||.|:|||||||||||||||||||:|||..| |:.:.|..:| ||:|:..| ..:.||:||||
Human   298 IFHKTCVDPWLLEHRTCPMCKCDILKALGIEVDVEDGSVSLQVP-VSNEISNS-ASSHEEDNRSE 360

Frog   343 MASSGYASVRGGDEPVDEGQHIY---ENTELVHNEASATSIEVLPHVDNPGFE-----SEDVHVH 399
            .||||||||:|.|||..| :|:.   |:.:||::||::.:::|:||||||.||     :::..|.
Human   361 TASSGYASVQGTDEPPLE-EHVQSTNESLQLVNHEANSVAVDVIPHVDNPTFEEDETPNQETAVR 424

Frog   400 EMKS 403
            |:||
Human   425 EIKS 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf128	XP_012824820.2	PA_GRAIL_like	38..174	CDD:239037	72/144 (50%)
		COG5540	<208..302	CDD:227827	75/93 (81%)
		RING-H2_RNF128_like	256..304	CDD:319716	41/47 (87%)
RNF128	NP_919445.1	PA_GRAIL_like	48..193	CDD:239037	72/144 (50%)
		RING-H2_RNF128_like	275..323	CDD:319716	41/47 (87%)
		RING-H2 finger (C3H2C3-type)	277..317	CDD:319716	33/39 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..428		37/83 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	154	1.000	Domainoid score	I20701
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	421	1.000	Inparanoid score	I8802
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG39235
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0011956
OrthoInspector	1	1.000	-	-		oto149435
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080