DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf128 and rnf128a

DIOPT Version :9

Sequence 1:	XP_012824820.2	Gene:	rnf128 / 100145171	XenbaseID:	XB-GENE-877067	Length:	403	Species:	Xenopus tropicalis
Sequence 2:	NP_997780.1	Gene:	rnf128a / 322325	ZFINID:	ZDB-GENE-030131-1044	Length:	389	Species:	Danio rerio

Alignment Length:	387	Identity:	201/387 - (51%)
Similarity:	257/387 - (66%)	Gaps:	31/387 - (8%)

- Green bases have known domain annotations that are detailed below.

Frog    19 LLLLNLSLTGADTLWTANVNYSYV--YDNRTYGEEGEIGVFGQDSPIERAAGLVVLPKSERTFTA 81
            |.:.::.|..|..|.||.:|.||.  .:||:...:.|:|::|||||.....|.|.|  :..|: .
Zfish    19 LQVSSVRLAEASYLCTAYLNISYTNPENNRSTWFQEEMGLYGQDSPKAYVKGNVYL--ASPTY-G 80

Frog    82 CKDNTNFSVPHNWNGPWIALILRGGGCTFTEKINRAAERGARAVVVYNN-GMDNEVFEMSHPGTK 145
            |.|:|.:..|:...| |||||.||.|||||||||.||..||.|.:::|: |.:|.|.:||||||
Zfish    81 CDDDTFYGRPNGSKG-WIALIQRGNGCTFTEKINIAAMNGAAAAIIFNDFGSENRVIQMSHPGT- 143

Frog   146 DTVAIMIGNIKGNEIVEVIKGGMQVMMVIEVGRKHGSWINHYSIFFVSVSFFIVTAATVGYFIFY 210
            ..|||||||.:|.|:|:::..|:.|.:.||||::||.|::|||:||||:||||||||||||||||
Zfish   144 TIVAIMIGNYRGMELVQLLDQGVPVAIAIEVGKQHGPWMSHYSVFFVSISFFIVTAATVGYFIFY 208

Frog   211 SARRWRLTRAQNKKMKQLKAEAKKAIGKLQLRTIKQGDKVLGPDGDSCAVCIEPYKPSDVVRILT 275
            ||||....|.||:..|:||||||||||:||:||::|||:.:|||.|:|||||:.||..||:.|||
Zfish   209 SARRLNSLRQQNRSQKKLKAEAKKAIGQLQVRTLRQGDQEIGPDADACAVCIDSYKAGDVLSILT 273

Frog   276 CNHFFHKNCIDPWLLEHRTCPMCKCDILKSLGIAEDEEETTSAAIP-----SVSSELQRSTVQTI 335
            |||||||:||:||||||||||||||||||:||:..|.||....::|     |.|.:|...|.
Zfish   274 CNHFFHKSCIEPWLLEHRTCPMCKCDILKALGVELDVEEQPQISVPDFRPFSTSEDLHSETA--- 335

Frog   336 EEENRSEMASSGYASVRGGDEPVDEGQHIYENTELVHNEASATSIEVLPHVDNPGFESEDVH 397
             ....||.|||||||:.|             |..|...|.:...::..||.||..||| |||
Zfish   336 -SHTHSETASSGYASMHG-------------NEHLAPPEGTHNGVQEEPHYDNLAFES-DVH 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf128	XP_012824820.2	PA_GRAIL_like	38..174	CDD:239037	64/138 (46%)
		COG5540	<208..302	CDD:227827	67/93 (72%)
		RING-H2_RNF128_like	256..304	CDD:319716	38/47 (81%)
rnf128a	NP_997780.1	PA_GRAIL_like	38..172	CDD:239037	64/138 (46%)
rnf128a	NP_997780.1	zf-RING_2	256..297	CDD:290367	32/40 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	134	1.000	Domainoid score	I20178
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	348	1.000	Inparanoid score	I8731
OMA	1	1.010	-	-		QHG39235
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0011956
OrthoInspector	1	1.000	-	-		oto77043
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.080