DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf128 and H10E21.5

DIOPT Version :9

Sequence 1:	XP_012824820.2	Gene:	rnf128 / 100145171	XenbaseID:	XB-GENE-877067	Length:	403	Species:	Xenopus tropicalis
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	206	Identity:	72/206 - (34%)
Similarity:	115/206 - (55%)	Gaps:	15/206 - (7%)

- Green bases have known domain annotations that are detailed below.

Frog   188 SIFFVSVSFFIVTAATVGYFIFYSARRWRLTRAQNKKMKQLKAEAKKAIGKLQLRTIKQG-DKVL 251
            |:.|||:||.|:...::.:.:||..:|:|...|:::..::|...|:||:.::...||..| .:.|
Worm   159 SVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITPGMTQEL 223

Frog   252 GPDGDSCAVCIEPYKPSDVVRILTCNHFFHKNCIDPWLLEHRTCPMCKCDILKSLG----IAEDE 312
            ..|   ||||::||:..||:|:|.|.|.:||:||||||||||||||||.||||..|    |..|.
Worm   224 QSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYWNDIRNDI 285

Frog   313 EETTSAAIPSVSSELQRSTVQTIEEENRSEMASSGYASVRGGDEPVDEGQHIYENTELVHNEA-- 375
            :..|::.  .::.:.   |::....|...:..|:...|.....:..|.....::|:|..|:|:
Worm   286 QMPTNSR--GIADDF---TIRLELGEQEHQAPSADVISPEANSDTSDSQGFSFDNSEHHHSESFG 345

Frog   376 SATSIEVLPHV 386
            ..||..|.|.:
Worm   346 YGTSSTVPPQL 356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf128	XP_012824820.2	PA_GRAIL_like	38..174	CDD:239037
		COG5540	<208..302	CDD:227827	44/94 (47%)
		RING-H2_RNF128_like	256..304	CDD:319716	32/47 (68%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	63/173 (36%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	33/49 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I5695
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm21426
Panther	1	1.100	-	-	O	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.010