Protein Alignment rnf139 and HRD1

DIOPT Version :9

• Sequence 1: NP_001116520.1
• Gene: rnf139 / 100144552
• ZFINID: ZDB-GENE-080401-4
• Length: 664
• Species: Danio rerio
• Sequence 2: NP_014630.1
• Gene: HRD1 / 854149
• SGDID: S000005373
• Length: 551
• Species: Saccharomyces cerevisiae
• Alignment Length: 564
• Identity: 104/564 - (18%)
• Similarity: 189/564 - (33%)
• Gaps: 207/564 - (36%)

Zfish    84 AASVLVNYYATAHADFYSAYNSAAVLPRDGPTLWLALALMQLLLGLGYVALLRVRSVCAALLLLD 148
            |..|:|.|..|    ||..|::...          :::.:|:.|.|.....|.|.|:   .:||:
Yeast    11 AIFVVVTYLLT----FYCVYSATKT----------SVSFLQVTLKLNEGFNLMVLSI---FILLN 58

Zfish   149 IMAPLWGLILELPADMKQVLAIASGVILATH---------AALNLLLKLKWFYYSCRYVYLLLRH 204
             ...||.|:.:|         :...:.|..|         ..:|.|.....|:.  ||.:.:
Yeast    59 -STLLWQLLTKL---------LFGELRLIEHEHIFERLPFTIINTLFMSSLFHE--RYFFTV--- 108

Zfish   205 MYRIYGLQLLLEDTWKRIRFPDILRVF-WLTRVTAQAVILLYVVRVVRSESGMQLGWDVLWDLSS 268
              ..:||.||            .|:|| |:.:...:|::     :.:...:.|:
Yeast   109 --AFFGLLLL------------YLKVFHWILKDRLEALL-----QSINDSTTMK----------- 143

Zfish   269 NLIISGCDSTLTVLGMSAVISSLAHYLGLSILAFIGSTEEEDKRLGFVAPVLFFILALQTGLSGL 333
            .||.|.....|.:|   ||:.   :.:....::.|.:.::.|    ..:..|:.|..::..:..:
Yeast   144 TLIFSRFSFNLVLL---AVVD---YQIITRCISSIYTNQKSD----IESTSLYLIQVMEFTMLLI 198

Zfish   334 DPEERLVRLSRNMCL-----------LLTAILHFIHGMTDPVLMSLSASHVSSVRRHVPVLLVSL 387
            |    |:.|....||           |.....|.:||  ||...:...|..|.
Yeast   199 D----LLNLFLQTCLNFWEFYRSQQSLSNENNHIVHG--DPTDENTVESDQSQ------------ 245

Zfish   388 VLFTLPVL---------------LSFLLWHHYALNTWL-FAVTAFCIELCLKVLVSLTVYALFMM 436
                 |||               |.....:..|::.:. |..||    |.|.:|:...:..:.:.
Yeast   246 -----PVLNDDDDDDDDDRQFTGLEGKFMYEKAIDVFTRFLKTA----LHLSMLIPFRMPMMLLK 301

Zfish   437 DGFYNVLWEKLDDYVYYVRSTGNVIEFIFGVIMFGNGAYTMMFESGSKIRACMMCLHAYFNIYLQ 501
            |    |:|:.|                             .:::||:.:
Yeast   302 D----VVWDIL-----------------------------ALYQSGTSL---------------- 317

Zfish   502 AKNGWKTFINRRTAVKKINSLPEVRGSRLRDI---EDVCAICYQEF------------GSSARIT 551
                ||.:.|.:   :..::|..|...:|::.   :::|.||..|.            ....:..
Yeast   318 ----WKIWRNNK---QLDDTLVTVTVEQLQNSANDDNICIICMDELIHSPNQQTWKNKNKKPKRL 375

Zfish   552 PCSHYFHALCLRKWLYIQDTCPMCHQRVYIEDDTSERSTFSNNN 595
            ||.|..|..||:.|:....|||:|...|:.|.....::||::|:
Yeast   376 PCGHILHLSCLKNWMERSQTCPICRLPVFDEKGNVVQTTFTSNS 419

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
rnf139	NP_001116520.1	TRC8_N	13..506	CDD:290425	78/458 (17%)
		zf-rbx1	516..576	CDD:289448	17/74 (23%)
		RING	537..579	CDD:238093	15/53 (28%)
HRD1	NP_014630.1	HRD1	5..551	CDD:227568	104/564 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6571
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940