DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kremen1 and SLG1

DIOPT Version :9

Sequence 1:	NP_001108389.1	Gene:	kremen1 / 100141352	ZFINID:	ZDB-GENE-070705-262	Length:	465	Species:	Danio rerio
Sequence 2:	NP_014650.1	Gene:	SLG1 / 854170	SGDID:	S000005534	Length:	378	Species:	Saccharomyces cerevisiae

Alignment Length:	313	Identity:	63/313 - (20%)
Similarity:	115/313 - (36%)	Gaps:	57/313 - (18%)

- Green bases have known domain annotations that are detailed below.

Zfish   115 LGCFKDSGDPTPLSGSH----QTSTKLTIQNCISFCRNQRYKLAGMESGYACFCGDDREYHRHGD 175
            :.||  |..|:..|.:.    |:|:     :|.|.|..:......:.:...|:|||...  ...:
Yeast    25 VNCF--SSLPSDFSKADSYNWQSSS-----HCNSECSAKGASYFALYNHSECYCGDTNP--SGSE 80

Zfish   176 APNTECNHVCFGDHTQPCGGDGRIIVF----DTKVGACGGNFTSPSAVIYSPDFPGKYRSGSVCY 236
            :.::.||..|||..::.|||:....|:    ||...:...:.:|..:...|        |.:...
Yeast    81 STSSSCNTYCFGYSSEMCGGEDAYSVYQLDSDTNSNSISSSDSSTESTSAS--------SSTTSS 137

Zfish   237 WTIQVPGSSVILFNFTFFSIVDQKDMVELLDGKTNQVVARFDGRNPPRDIV---NITADFVILYF 298
            .|.....::....:.|..|:.....:..  ..::.|..|..........:.   ::|:|.:....
Yeast   138 TTSSTTSTTSSTTSSTTSSMASSSTVQN--SPESTQAAASISTSQSSSTVTSESSLTSDTLATSS 200

Zfish   299 YSDRTNEALGFSVVYHALRNPAFRPEEEDNGDEEDTST-MRPNSGSTT-TKSNTSQSGKSSHLYY 361
            .|.::.:|.  |::|    :..|..|........:|.| ...||||.| |..:.|.||..:|
Yeast   201 TSSQSQDAT--SIIY----STTFHTEGGSTIFVTNTITASAQNSGSATGTAGSDSTSGSKTH--- 256

Zfish   362 VITSSPANMPGQWHGPGRTAGHNTMWTIYALAALLTLTVIAMVAKLLLHLTVK 414
               ...||:       |...|......:.|:|..|.:.:|      :.|:.:|
Yeast   257 ---KKKANV-------GAIVGGVVGGVVGAVAIALCILLI------VRHINMK 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kremen1	NP_001108389.1	KR	26..109	CDD:238056
		WSC	114..195	CDD:280068	20/83 (24%)
		CUB	209..315	CDD:238001	14/108 (13%)
SLG1	NP_014650.1	WSC	22..110	CDD:214616	23/93 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4157
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900