Protein Alignment kremen1 and ZNRF3

DIOPT Version :9

• Sequence 1: NP_001108389.1
• Gene: kremen1 / 100141352
• ZFINID: ZDB-GENE-070705-262
• Length: 465
• Species: Danio rerio
• Sequence 2: NP_001193927.1
• Gene: ZNRF3 / 84133
• HGNCID: 18126
• Length: 936
• Species: Homo sapiens
• Alignment Length: 262
• Identity: 50/262 - (19%)
• Similarity: 79/262 - (30%)
• Gaps: 111/262 - (42%)

Zfish   154 AGMESGYACFCGDDREYHRH--------GDAPNTECN--------HVCFGDHTQPCGGDGRIIVF 202
            :|..|.::|       ||.|        .|.|.::.:        |....|....|
Human   523 SGSTSSFSC-------YHGHRSVCSGYLADCPGSDSSSSSSSGQCHCSSSDSVVDC--------- 571

Zfish   203 DTKV------GACGGNFTSPSAVIYSPDFPGKYRSGSVCYWTIQVPGSSVILFNFTFFSIVDQKD 261
             |:|      |:| ..|.|..:..|.|..   |||.|.|. ..:..||
Human   572 -TEVSNQGVYGSC-STFRSSLSSDYDPFI---YRSRSPCR-ASEAGGS----------------- 613

Zfish   262 MVELLDGKTNQVVAR-FDGRNPPRDIVNITADFVILYFYSDRTNEALGFSVVYHALRNPAFRPEE 325
                  |.:.:..|. |:|..||.::..:.:                     :.|.|...:....
Human   614 ------GSSGRGPALCFEGSPPPEELPAVHS---------------------HGAGRGEPWPGPA 651

Zfish   326 EDNGDEEDTSTMRPNSGSTTT------KSNTSQSGKSSHLYYVITSSPANMPG---QWHGPGRTA 381
            ..:||:..|.::..|..|.::      .|:||:.|        :.:||...|.   .|.|
Human   652 SPSGDQVSTCSLEMNYSSNSSLEHRGPNSSTSEVG--------LEASPGAAPDLRRTWKG----- 703

Zfish   382 GH 383
            ||
Human   704 GH 705

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
kremen1	NP_001108389.1	KR	26..109	CDD:238056
		WSC	114..195	CDD:280068	11/56 (20%)
		CUB	209..315	CDD:238001	18/106 (17%)
ZNRF3	NP_001193927.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31
		zf-RING_2	293..334	CDD:290367
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	608..693		21/136 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	739..758
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	849..875
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	892..936

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	510	1.000	Domainoid score	I2629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1025	1.000	Inparanoid score	I2202
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG40703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto46572
orthoMCL	1	0.900	-	-		OOG6_113589
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900