DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kremen1 and Znrf3

DIOPT Version :9

Sequence 1:	NP_001108389.1	Gene:	kremen1 / 100141352	ZFINID:	ZDB-GENE-070705-262	Length:	465	Species:	Danio rerio
Sequence 2:	NP_001074393.1	Gene:	Znrf3 / 407821	MGIID:	3039616	Length:	913	Species:	Mus musculus

Alignment Length:	139	Identity:	34/139 - (24%)
Similarity:	40/139 - (28%)	Gaps:	57/139 - (41%)

- Green bases have known domain annotations that are detailed below.

Zfish    26 ECYTANGEDYRGRQNQTSLQG------------------GRPCLFWNETFERPYNTNKYPNGEGG 72
            :|...:||...|     |.||                  |.||.|:.|         |......|
Mouse   723 DCNPPSGEPQLG-----SSQGLYGLHSDHYPRTDGVKYEGLPCCFYEE---------KQVAHSAG 773

Zfish    73 LGQHNFCRNPDGDVR----------PWCYIA--DLEDGSYWKYCDIPTCQMPGNLGCFKDSGDPT 125
            .|  |.|...|..|.          |.||..  ||..       .||.  :|.::.|  |.|.|.
Mouse   774 RG--NGCYTEDYSVSVQYTLTEEPPPSCYAGPRDLSQ-------RIPI--IPEDVDC--DLGLPQ 825

Zfish   126 PLSGSHQTS 134
            ...|.|..|
Mouse   826 DCHGMHNHS 834

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kremen1	NP_001108389.1	KR	26..109	CDD:238056	26/112 (23%)
		WSC	114..195	CDD:280068	7/21 (33%)
		CUB	209..315	CDD:238001
Znrf3	NP_001074393.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		zf-RING_2	289..331	CDD:290367
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	601..669
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	855..913
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	491	1.000	Domainoid score	I2847
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	997	1.000	Inparanoid score	I2299
OMA	1	1.010	-	-		QHG40703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0013402
OrthoInspector	1	1.000	-	-		oto56871
orthoMCL	1	0.900	-	-		OOG6_113589
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R768
SonicParanoid	1	1.000	-	-		X4852
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.900