DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HDAC5 and hdac5

DIOPT Version :9

Sequence 1:	XP_016879477.1	Gene:	HDAC5 / 10014	HGNCID:	14068	Length:	1161	Species:	Homo sapiens
Sequence 2:	XP_685659.5	Gene:	hdac5 / 557486	ZFINID:	ZDB-GENE-121219-3	Length:	1128	Species:	Danio rerio

Alignment Length:	1196	Identity:	811/1196 - (67%)
Similarity:	919/1196 - (76%)	Gaps:	133/1196 - (11%)

- Green bases have known domain annotations that are detailed below.

Human     7 SADGMSGREPSLEILPRTSLHSIPVTVGRRQRARRAGIKPWVLHLLSRPGQEQELFPNLQETEQV 71
            |:|..|.||..:|:||::...|:|.|                                      |
Zfish    25 SSDSTSSRERPVELLPQSRSTSMPST--------------------------------------V 51

Human    72 EVKPVLPRAMPSSMGGG---GGGSPSPVELRG----ALVGSVDPTLREQQLQQELLALKQQQQLQ 129
            :||.:||..|.|.:|||   ||||..||:||.    :.:.:|||:|||:|||.|||.|||||:||
Zfish    52 DVKTLLPSGMQSPVGGGGDQGGGSGGPVDLRTDPRLSALSAVDPSLREKQLQHELLLLKQQQELQ 116

Human   130 KQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEEL 194
            ||||||||||||:.||||||||||:||         |||||:|||||||||||:|:.||||.||:
Zfish   117 KQLLFAEFQKQHEVLTRQHEVQLQEHL---------KQQQEILAAKRQQELEQKRKLEQQRHEEM 172

Human   195 EKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHAS 259
            |||||||||::||||||.||||||||||||:|||||||| |||.|||||||.||  |||||||.|
Zfish   173 EKQRLEQQLIMLRNKEKGKESAIASTEVKLKLQEFLLSK-KEPGPGGLNHSFPQ--KCWGAHHTS 234

Human   260 LDQSSPPQSGPPGTPPSYKL-PLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRR 323
            |:|||||||..||||||||| ||.|.|:.:|||||||||||||||||||||||||||||||||||
Zfish   235 LEQSSPPQSNTPGTPPSYKLPPLLGSYEGKDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRR 299

Human   324 KDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQ- 387
            |||||||||||||:||:     .||:|:|||||||||||||:..|||||.:||||||..|.|..
Zfish   300 KDGTVISTFKKRAIEIS-----VSSMCSSAPGSGPSSPNSSNCAIAENGSSGSVPNIHAEQLRSL 359

Human   388 HRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTL 452
            |::|..|.:|:..|||||||||||||||.|     |:|:||..|||.|||||||.:|||||||.|
Zfish   360 HQSLTGDGAPSPLSLYTSPSLPNISLGLPA-----NAHITAPQKLSAQQEAERQTIQSLRQGGAL 419

Human   453 TGKFMSTSSIPGCLLGVALEGDGSPH------------GHASLLQHVLLLEQARQQSTLIAVPLH 505
            ||||:||||:|.||      ..|:||            .|:||||||||||||||||.|:|||::
Zfish   420 TGKFISTSSLPTCL------STGAPHDPEPPAASNSHSSHSSLLQHVLLLEQARQQSALLAVPMY 478

Human   506 GQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQL 570
            |||||||||||:.:||||.|||||||||||||:||||:|||||.||||||||.||||||  ..||
Zfish   479 GQSPLVTGERVSNNMRTVNKLPRHRPLSRTQSAPLPQTPQALQHLVMQQQHQHFLEKQK--HYQL 541

Human   571 GKILTKTGELPRQPTTHPEETEEELTEQQEVL--LGEG------ALTMPREGST----------E 617
            .|||:|..:|||||.||||||||||||..|:.  .|||      .|.....|.|          :
Zfish   542 NKILSKGTDLPRQPPTHPEETEEELTETAEMQDERGEGPDHVREGLQKDSSGETTPPSERIVPLK 606

Human   618 SESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQ 682
            .|||:.||||||:||:..|..:|    ||:...|.                :.|.|.:|.|.|:|
Zfish   607 GESTESDLEEEDDEDEAVELREC----DEDAPYGQ----------------YLDQQHVQQLNVFQ 651

Human   683 APLSLATVPHQALGRTQSSPAAPGGMKSPP--DQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPE 745
            |.||:..:||:.|||.||||.. ..:|...  :.|:|||||||:||||||||||||||||::|||
Zfish   652 ASLSITGMPHRPLGRAQSSPVT-SSLKGTTLNEVPIKHLFTTGLVYDTFMLKHQCMCGNTNIHPE 715

Human   746 HAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPI 810
            |||||||:||||||||||.:|||||||||||||||||||||||||||||||||||||||||||||
Zfish   716 HAGRIQSVWSRLQETGLLGRCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPI 780

Human   811 SQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEE 875
            |||||||||||||||||||||||||||.||||||||::||||||||||||||||::|||||||||
Zfish   781 SQKMYAVLPCGGIGVDSDTVWNEMHSSGAVRMAVGCVIELAFKVAAGELKNGFAVVRPPGHHAEE 845

Human   876 STAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFF 940
            |||||||||||||||||||||||.|||:||:||||||||||||||||||:||||||||||:||||
Zfish   846 STAMGFCFFNSVAITAKLLQQKLGVGKILIIDWDIHHGNGTQQAFYNDPNVLYISLHRYDDGNFF 910

Human   941 PGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAV 1005
            ||||||||||.|||.|:|||:||||||:||:|||||||||||||||||:||||||||||||||||
Zfish   911 PGSGAPEEVGVGPGEGFNVNIAWTGGVEPPMGDVEYLTAFRTVVMPIANEFSPDVVLVSAGFDAV 975

Human  1006 EGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLD 1070
            |||.||||||:|||:||||||:|||.||||||||||||||||||||||||:||.|||..||.||.
Zfish   976 EGHQSPLGGYNVTAKCFGHLTKQLMKLAGGRVVLALEGGHDLTAICDASESCVEALLGDELNPLP 1040

Human  1071 EAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGA 1135
            ..||||||...|.|:||:|||||||||:.:|:.|..:|:||.:||..|.:||:|::|||.|:|..
Zfish  1041 LTVLQQKPCPKATASLERVIEIQSKHWTSLQRLAPTVGQSLLDAQRREKDEADTLTAMASLTVDN 1105

Human  1136 EQAQAAAAREHSPRPAEEPMEQEPAL 1161
            ||...:.   .:.|.||||||:||.|
Zfish  1106 EQQTTST---ETSRSAEEPMEEEPVL 1128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HDAC5	XP_016879477.1	None
hdac5	XP_685659.5	ClassIIa_HDAC5_Gln-rich-N	94..181	CDD:197400	72/95 (76%)
hdac5	XP_685659.5	HDAC5	688..1107	CDD:212531	354/418 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194338668
Domainoid	1	1.000	641	1.000	Domainoid score	I1431
eggNOG	1	0.900	-	-		E1_COG0123
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3995
Inparanoid	1	1.050	1523	1.000	Inparanoid score	I908
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG46994
OrthoDB	1	1.010	-	-		D119187at33208
OrthoFinder	1	1.000	-	-		FOG0001001
OrthoInspector	1	1.000	-	-		otm28432
orthoMCL	1	0.900	-	-		OOG6_100220
Panther	1	1.100	-	-	LDO	PTHR48252
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2991
SonicParanoid	1	1.000	-	-		X933
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	1	1.500	-	-
	19	19.300