Protein Alignment HDAC5 and hdac5

DIOPT Version :10

• Sequence 1: NP_001015053.1
• Gene: HDAC5 / 10014
• HGNCID: 14068
• Length: 1123
• Species: Homo sapiens
• Sequence 2: XP_685659.5
• Gene: hdac5 / 557486
• ZFINID: ZDB-GENE-121219-3
• Length: 1128
• Species: Danio rerio
• Alignment Length: 1158
• Identity: 811/1158 - (70%)
• Similarity: 919/1158 - (79%)
• Gaps: 95/1158 - (8%)

Human     7 SADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGG---GGGSPSPVELRG----AL 64
            |:|..|.||..:|:||::...|:|.||:||.:||..|.|.:|||   ||||..||:||.    :.
Zfish    25 SSDSTSSRERPVELLPQSRSTSMPSTVDVKTLLPSGMQSPVGGGGDQGGGSGGPVDLRTDPRLSA 89

Human    65 VGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQ 129
            :.:|||:|||:|||.|||.|||||:||||||||||||||:.||||||||||:||         ||
Zfish    90 LSAVDPSLREKQLQHELLLLKQQQELQKQLLFAEFQKQHEVLTRQHEVQLQEHL---------KQ 145

Human   130 QQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLS 194
            |||:|||||||||||:|:.||||.||:|||||||||::||||||.||||||||||||:|||||||
Zfish   146 QQEILAAKRQQELEQKRKLEQQRHEEMEKQRLEQQLIMLRNKEKGKESAIASTEVKLKLQEFLLS 210

Human   195 KSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKL-PLPGPYDSRDDFPLRKT 258
            | |||.|||||||.||  |||||||.||:|||||||..||||||||| ||.|.|:.:||||||||
Zfish   211 K-KEPGPGGLNHSFPQ--KCWGAHHTSLEQSSPPQSNTPGTPPSYKLPPLLGSYEGKDDFPLRKT 272

Human   259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSP 323
            ||||||||||||||||||||||||||||||||||||||||:||:     .||:|:||||||||||
Zfish   273 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAIEIS-----VSSMCSSAPGSGPSSP 332

Human   324 NSSHSTIAENGFTGSVPNIPTEMLPQ-HRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSH 387
            |||:..|||||.:||||||..|.|.. |::|..|.:|:..|||||||||||||||.|     |:|
Zfish   333 NSSNCAIAENGSSGSVPNIHAEQLRSLHQSLTGDGAPSPLSLYTSPSLPNISLGLPA-----NAH 392

Human   388 LTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPH------------ 440
            :||..|||.|||||||.:|||||||.|||||:||||:|.||      ..|:||
Zfish   393 ITAPQKLSAQQEAERQTIQSLRQGGALTGKFISTSSLPTCL------STGAPHDPEPPAASNSHS 451

Human   441 GHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQS 505
            .|:||||||||||||||||.|:|||::|||||||||||:.:||||.|||||||||||||:||||:
Zfish   452 SHSSLLQHVLLLEQARQQSALLAVPMYGQSPLVTGERVSNNMRTVNKLPRHRPLSRTQSAPLPQT 516

Human   506 PQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVL--LGEG 568
            |||||.||||||||.||||||  ..||.|||:|..:|||||.||||||||||||..|:.  .|||
Zfish   517 PQALQHLVMQQQHQHFLEKQK--HYQLNKILSKGTDLPRQPPTHPEETEEELTETAEMQDERGEG 579

Human   569 ------ALTMPREGST----------ESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEG 617
                  .|.....|.|          :.|||:.||||||:||:..|..:|    ||:...|.
Zfish   580 PDHVREGLQKDSSGETTPPSERIVPLKGESTESDLEEEDDEDEAVELREC----DEDAPYGQ--- 637

Human   618 PDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP--DQPVKH 680
                         :.|.|.:|.|.|:||.||:..:||:.|||.||||.. ..:|...  :.|:||
Zfish   638 -------------YLDQQHVQQLNVFQASLSITGMPHRPLGRAQSSPVT-SSLKGTTLNEVPIKH 688

Human   681 LFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVH 745
            |||||:||||||||||||||||::||||||||||:||||||||||.:||||||||||||||||||
Zfish   689 LFTTGLVYDTFMLKHQCMCGNTNIHPEHAGRIQSVWSRLQETGLLGRCERIRGRKATLDEIQTVH 753

Human   746 SEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLL 810
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||||::
Zfish   754 SEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSGAVRMAVGCVI 818

Human   811 ELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 875
            ||||||||||||||||::||||||||||||||||||||||||||||||||.|||:||:|||||||
Zfish   819 ELAFKVAAGELKNGFAVVRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLGVGKILIIDWDIHHG 883

Human   876 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLT 940
            |||||||||||:||||||||||:||||||||||||||.|||.|:|||:||||||:||:|||||||
Zfish   884 NGTQQAFYNDPNVLYISLHRYDDGNFFPGSGAPEEVGVGPGEGFNVNIAWTGGVEPPMGDVEYLT 948

Human   941 AFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEG 1005
            ||||||||||:|||||||||||||||||||.||||||:|||:||||||:|||.||||||||||||
Zfish   949 AFRTVVMPIANEFSPDVVLVSAGFDAVEGHQSPLGGYNVTAKCFGHLTKQLMKLAGGRVVLALEG 1013

Human  1006 GHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLG 1070
            ||||||||||||:||.|||..||.||...||||||...|.|:||:|||||||||:.:|:.|..:|
Zfish  1014 GHDLTAICDASESCVEALLGDELNPLPLTVLQQKPCPKATASLERVIEIQSKHWTSLQRLAPTVG 1078

Human  1071 RSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
            :||.:||..|.:||:|::|||.|:|..||...:.   .:.|.||||||:||.|
Zfish  1079 QSLLDAQRREKDEADTLTAMASLTVDNEQQTTST---ETSRSAEEPMEEEPVL 1128

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HDAC5	NP_001015053.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..61		11/21 (52%)
		ClassIIa_HDAC5_Gln-rich-N	69..165	CDD:197400	72/95 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..282		71/85 (84%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..344		27/40 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..505		20/22 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	537..626		41/106 (39%)
		HDAC5	680..1096	CDD:212531	353/415 (85%)
		Histone deacetylase	685..1029		311/343 (91%)
		Nuclear export signal	1082..1123		19/40 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1098..1123		11/24 (46%)
hdac5	XP_685659.5	ClassIIa_HDAC5_Gln-rich-N	94..181	CDD:197400	72/95 (76%)
		HDAC5	688..1107	CDD:212531	354/418 (85%)