DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO6 and HCM1

DIOPT Version :10

Sequence 1:NP_001278210.2 Gene:FOXO6 / 100132074 HGNCID:24814 Length:559 Species:Homo sapiens
Sequence 2:NP_009991.2 Gene:HCM1 / 850429 SGDID:S000000661 Length:564 Species:Saccharomyces cerevisiae


Alignment Length:163 Identity:52/163 - (31%)
Similarity:76/163 - (46%) Gaps:33/163 - (20%)


- Green bases have known domain annotations that are detailed below.


Human    56 ERRATAPAMAPAPPLGAEVGPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVR 120
            |||.....:|..||                     .|||.||..||..:.:.:|||||||.|:..
Yeast    98 ERRRINGELAKKPP---------------------YSYATLICLAILQSQEGKLTLSQIYHWIHV 141

Human   121 YVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKT----GKTPRRR 181
            :.||:|.|     .|.|:|||||||||:..||:.:....||..:|.:.| |.:|    |:.....
Yeast   142 HFPYYKQK-----DASWQNSIRHNLSLNDAFIKTEKSCDGKGHFWEVRP-GAETKFFKGENRGYE 200

Human   182 AV--SMDNGAKFLRIKGKASKKKQLQAPERSPD 212
            .|  |:.:..|:..|.....:.:|:::.|.:.|
Yeast   201 FVKDSLQDIGKYFEIDSTLDELEQVESGEGNDD 233

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO6NP_001278210.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 6/19 (32%)
FH_FOXO6 89..176 CDD:410837 38/90 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..235 12/56 (21%)
FOXO_KIX_bdg 358..>382 CDD:465228
FOXO-TAD 499..537 CDD:435506
HCM1NP_009991.2 COG5025 20..564 CDD:227358 52/163 (32%)
Blue background indicates that the domain is not in the aligned region.

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