Protein Alignment FOXO6 and foxo6b

DIOPT Version :10

• Sequence 1: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_001128604.2
• Gene: foxo6b / 566899
• ZFINID: ZDB-GENE-060503-776
• Length: 714
• Species: Danio rerio
• Alignment Length: 744
• Identity: 272/744 - (36%)
• Similarity: 335/744 - (45%)
• Gaps: 231/744 - (31%)

Human     7 AHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGAGV----AEGAEDCGPERRATAPAMAPA 67
            ||||::|.|:.|..||||||||||.|:   :|..||...|    .......|.......||.|||
Zfish    11 AHQVELDADYEPHCRPRSCTWPLPCPE---EESRALPVKVEPRNVPACRSGGAPTEFKHPAGAPA 72

Human    68 PPLGAE----------VGPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYV 122
            |...|.          .|.|||:||||||||||.|||||||:||||.|:||||||||||||||:|
Zfish    73 PIAAAPACMSGAALDVAGQLRKSKSSRRNAWGNQSYADLITRAIESTPEKRLTLSQIYDWMVRFV 137

Human   123 PYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMDN 187
            |||||||||||||||||||||||||||||||||||||||||||||||||||.||.||||||||||
Zfish   138 PYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKMGKGPRRRAVSMDN 202

Human   188 GAKFLRIKGKASKK--------KQLQAP--ERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDY 242
            |.|:|:.:|:.|:|        ::|.||  :.||:..||:......:             .|:::
Zfish   203 GTKYLKSRGRVSRKRTAAVGMGRELGAPGIQGSPEHGSPAGKGVMGI-------------GSEEF 254

Human   243 EAWADFR-----------GGGRPLLGEAAELEDDEALEA--LAPSSPLMYPSPASALSPALGS-- 292
            :||.|..           |...|:|   ||.|.||..|.  ...:||.:||||.|..|||||:
Zfish   255 DAWTDLHSRTSSSASTLSGCLSPIL---AETEPDEPEEGGLSCSASPRLYPSPTSTRSPALGTGG 316

Human   293 RCPG-ELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPRARAGTPAYFGGCKGGAYGGGGGF 356
            .||. |||.||:|.|.:.|..|....||   |......|||..:|.| :|.|..          :
Zfish   317 HCPSVELPHLADLTGAISLEEGYSQPLP---LKRNGYHYGPAPKAET-SYCGTV----------Y 367

Human   357 GPPAMGALR-RLPMQTIQENKQASFVPAAAPF-RPGALPALLPPPPPAPRPGPVLGAPGE----L 415
            |.|:||.|| ..|||||||||..||..|...: ...||.:||...|.......|:|..|.    :
Zfish   368 GQPSMGMLRHHTPMQTIQENKPTSFQRALRAYSENNALESLLAGGPQYCGKDMVVGQGGTSHSLM 432

Human   416 ALAGAAA---------------------------------------------------------- 422
            :.:..|.
Zfish   433 SQSNTAVHSHGHNQSHNHSQNHNHNPEHGHNRNSSQSLHNGHGVTHEQNPSHHHNPNQAHNKHHP 497

Human   423 ------------------------------------------------------AYPGKGAAPYA 433
                                                                  .|..|..:.|.
Zfish   498 SLDYNHHKQHRGHDYVQSHDHKLNASPNHMHNHLQHNNSRQPDLSPRVSNDMLQPYNHKSPSLYG 562

Human   434 PPA--PSRSALAHPISLMTLPGEAGAAGLAPSGHAAAFGGPPGGLLLDALPGPY----------- 485
            |.|  ||.:...:|.|::.:|.:......||.....::   ||..|...:..|:
Zfish   563 PRAHLPSTALPPNPASVLDVPQDPCRLASAPHPRHQSY---PGSHLHQGMTEPWQGYYHHTSQNA 624

Human   486 -------AAAAAGPLGAAPDRFPADLDLDMFSGSLECDVESIILNDFMDSDE-MDFNFDSALPP- 541
                   |:....|    .:|..::|::|:...||:||||||:|||||||.| ||||||.:|..
Zfish   625 NYHGNHQASHHHDP----QNRLQSELEMDVHQSSLDCDVESILLNDFMDSTEGMDFNFDGSLSQG 685

Human   542 --------PPPGLAGAPPP---NQSWVPG 559
                    ...|:...|..   :||||||
Zfish   686 VGMGMGLGMGMGVFAGPQQSHNSQSWVPG 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		30/82 (37%)
		FH_FOXO6	89..176	CDD:410837	80/86 (93%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		36/81 (44%)
		FOXO_KIX_bdg	358..>382	CDD:465228	16/24 (67%)
		FOXO-TAD	499..537	CDD:435506	24/38 (63%)
foxo6b	NP_001128604.2	FH_FOXO6	104..191	CDD:410837	80/86 (93%)
		FOXO_KIX_bdg	364..443	CDD:465228	28/88 (32%)
		PAT1	<476..>636	CDD:401645	17/162 (10%)
		FOXO-TAD	641..681	CDD:435506	25/39 (64%)