Protein Alignment FOXO6 and foxo6a

DIOPT Version :10

• Sequence 1: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Sequence 2: XP_690041.2
• Gene: foxo6a / 561541
• ZFINID: ZDB-GENE-110914-126
• Length: 594
• Species: Danio rerio
• Alignment Length: 673
• Identity: 235/673 - (34%)
• Similarity: 301/673 - (44%)
• Gaps: 208/673 - (30%)

Human     7 AHQVDVDPDFAPQSRPRSCTWPLPQPDLAGD---EDGALGAGVAEGAEDCGPERRATAPAMAPAP 68
            |||||::.:..  |..|||:|   ..|.:.|   .|.:|...:.:...|           .||:|
Zfish    10 AHQVDMESELG--SAARSCSW---TNDFSCDVVNADLSLNLSIFQVDSD-----------RAPSP 58

Human    69 PLGAEV-------------GPLRKAK-SSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMV 119
            .....:             ..|||.| |||||||||.|||:|||:||||.|||||||||||||||
Zfish    59 SCRRRMMVLDAGGFHDLTGAALRKTKASSRRNAWGNQSYAELITRAIESTPDKRLTLSQIYDWMV 123

Human   120 RYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVS 184
            ||||||||||||||||||||||||||||||||||||||||||||||||||||||.||:.||||||
Zfish   124 RYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKLGKSQRRRAVS 188

Human   185 MDNGAKFLRIKGKASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKWAASPASH-----ASDDYEA 244
            ||||.|.|:.||:.::||.....|:|.:             ...::.:||.|.     ..|:::.
Zfish   189 MDNGIKPLKSKGRTNRKKTTGKREQSTE-------------TLLEFCSSPDSGTGRIVVKDEFDT 240

Human   245 WADFRGGG-----------RPLLGEAAELEDDEALEALAPSSPLMYPSPASALSPALGSRCPGEL 298
            |.|....|           .|:||| .||.:.|.......:||.::|||:||.|||  |.||.:|
Zfish   241 WTDLHSLGSSSTSTLSGHLSPILGE-GELGEPEERRKSCSASPRLFPSPSSAHSPA--SHCPTDL 302

Human   299 PRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPRARAGTPAYFGGC--------------KGGA 349
                                              ||..|...:...|              :|.:
Zfish   303 ----------------------------------RATIGYKQHQSPCHKNPHYHYVSDIKSQGSS 333

Human   350 YGGGGGFGPPAMGALRRLPMQTIQENKQA----------------SFVPAAAPFRPGALPALL-- 396
            ......:|.|.:| :.|..:.|.::|..:                .||......:...:.:::
Zfish   334 CETQPVYGLPDVG-MHRSSIPTTEDNSGSMQGASTIQNLLTTGPQQFVKEMMHGKENEVHSMMVS 397

Human   397 -------PPPPPAP------------RPGPVLGAPGELALAGAAAAYPGKGAAPYAPPA----PS 438
                   |.....|            ||..|...|.:    |...:|..|....|:||.    |:
Zfish   398 QGLHPSNPNTSSKPFHNIIQSLSQDHRPTSVHSQPTD----GHMQSYMHKSPYLYSPPVTVHLPA 458

Human   439 RSALAHPISLMTLPGEAGAAGLA-----------PSGHAAAFGGPPGGLLLDALPGPYAAAAAGP 492
            .:||          ..||..|:|           |..|:..:..|....|...|   |..    |
Zfish   459 STAL----------NPAGVQGIAQDTCHLATTPYPQPHSYVYTDPHEHSLAYGL---YRQ----P 506

Human   493 LGAAP---------------DRFPADLDLDMFSGSLECDVESIILNDFMDS-DEMDFNFDSALPP 541
            .|...               :|.|||||:|:|..||:||:|||:|:|.||| :|:||||||:|..
Zfish   507 QGTGTGYHNYHHHPHQLYQHERLPADLDMDVFYSSLDCDMESILLHDIMDSGEEIDFNFDSSLTQ 571

Human   542 PPP---GLAGAPPPN--QSWVPG 559
            ...   |..|.|..:  ||||||
Zfish   572 GMGVGFGFTGTPQTHSKQSWVPG 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		18/84 (21%)
		FH_FOXO6	89..176	CDD:410837	81/86 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		32/71 (45%)
		FOXO_KIX_bdg	358..>382	CDD:465228	6/39 (15%)
		FOXO-TAD	499..537	CDD:435506	25/38 (66%)
foxo6a	XP_690041.2	FH_FOX	93..180	CDD:469596	81/86 (94%)
		FOXO-TAD	528..568	CDD:435506	26/39 (67%)