Protein Alignment FOXO6 and foxo

DIOPT Version :10

• Sequence 1: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_650330.3
• Gene: foxo / 41709
• FlyBaseID: FBgn0038197
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 619
• Identity: 188/619 - (30%)
• Similarity: 244/619 - (39%)
• Gaps: 232/619 - (37%)

Human    12 VDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGAGVAEGAEDC-GPERRATAPAMAPAPPLGAEVG 75
            :|..|.||:|.||.|||.|:|:...:....|.:..|...:.. |..::|...|.|
  Fly    30 LDVGFEPQTRARSNTWPCPRPENFVEPTDELDSTKASNQQLAPGDSQQAIQNANA---------- 84

Human    76 PLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNS 140
              .|..|||||||||||||||||.||.||.||||||||||:|||:.|||||||||||||||||||
  Fly    85 --AKKNSSRRNAWGNLSYADLITHAIGSATDKRLTLSQIYEWMVQNVPYFKDKGDSNSSAGWKNS 147

Human   141 IRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKGKASKKKQL- 204
            ||||||||.||:|||||||||||||||||| .|.||:.||||.||:. :::.:.:|:|.|:.:.
  Fly   148 IRHNLSLHNRFMRVQNEGTGKSSWWMLNPE-AKPGKSVRRRAASMET-SRYEKRRGRAKKRVEAL 210

Human   205 -QAPERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGEAAELEDDEAL 268
             ||.....:|::|                ||:|..|:..:.:
  Fly   211 RQAGVVGLNDATP----------------SPSSSVSEGLDHF----------------------- 236

Human   269 EALAPSSPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPR 333
                |.||                                 ||.|||..|....          |
  Fly   237 ----PESP---------------------------------LHSGGGFQLSPDF----------R 254

Human   334 ARAGTPAYFGGCKGGAYGGGGGFGP-------PAMG--------ALRRLPMQTIQE--------- 374
            .||.:.|  ..|        |...|       |..|        .:.:...|.::|
  Fly   255 QRASSNA--SSC--------GRLSPIRAQDLEPDWGFPVDYQNTTMTQAHAQALEELTGTMADEL 309

Human   375 ---NKQASFVPAAAPFRPGALPALLPPPPPAP-----------RPGPVLGAPGELALAGAAAAY- 424
               |:|.....||:     .||:..||||..|           :..|       .||.|.|:.|
  Fly   310 TLCNQQQQGFSAAS-----GLPSQPPPPPYQPPQHQQAQQQQQQQSP-------YALNGPASGYN 362

Human   425 ---------------------PGKGAAP----------YAPPAPSRSALAHPISLMTLPGEAG-- 456
                                 ...|.:|          |....||..:| :..|.:.|.|.|.
  Fly   363 TLQPQSQCLLHRSLNCSCMHNARDGLSPNSVTTTMSPAYPNSEPSSDSL-NTYSNVVLDGPADTA 426

Human   457 ----------------AAGLAPSGHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAAPDRFPADLD 505
                            :|.|..:..|:...|.    .|:.|..     .|.|:    |.|    :
  Fly   427 ALMVQQQQQQQQQQQLSASLEDNNCASTLIGQ----CLEVLNN-----EAQPI----DEF----N 474

Human   506 LDMFS-GSLECDVESIILNDFMDSDEMDFNFDSA 538
            |:.|. |:|||:||.::..:......:|.|...|
  Fly   475 LENFPVGNLECNVEELLQQEMSYGGLLDINIPLA 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		18/64 (28%)
		FH_FOXO6	89..176	CDD:410837	75/86 (87%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		25/73 (34%)
		FOXO_KIX_bdg	358..>382	CDD:465228	7/50 (14%)
		FOXO-TAD	499..537	CDD:435506	11/38 (29%)
foxo	NP_650330.3	FH_FOXO	96..175	CDD:410806	70/78 (90%)