DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO6 and fhl1

DIOPT Version :10

Sequence 1:NP_001278210.2 Gene:FOXO6 / 100132074 HGNCID:24814 Length:559 Species:Homo sapiens
Sequence 2:NP_594272.1 Gene:fhl1 / 2541552 PomBaseID:SPAC1142.08 Length:743 Species:Schizosaccharomyces pombe


Alignment Length:512 Identity:110/512 - (21%)
Similarity:181/512 - (35%) Gaps:192/512 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    18 PQSRPRSCTWPLPQPDLAGDEDGALGAGVAEGAEDCGPERRATAPA-------MAPAPPLG-AEV 74
            |..||.|...|:       :.|.::.|......::...:.::|:|:       :..:|..| |..
pombe   233 PYVRPTSDERPI-------ETDSSVSAPKVANHDEELKQGKSTSPSDTVLHPDLNGSPDTGDATQ 290

Human    75 GPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKN 139
            .|             |||||:||.:.:.:.|:|::||..|.:|:.....|::     :....|.|
pombe   291 KP-------------NLSYANLIARTLIANPNKKMTLGDICEWIANNWSYYR-----HQPPAWHN 337

Human   140 SIRHNLSLHTRFIRV---QNEGTGKSSWWMLNP------EGG--KTGKTPRRRA-------VSMD 186
            ||||||||:..|||:   ||| .||.|:|||:|      ||.  :..|.|...|       .:.:
pombe   338 SIRHNLSLNKAFIRIPRRQNE-PGKGSFWMLDPSYIDQFEGNFFRRTKKPTPSATPAAHPDTARE 401

Human   187 NGAKFLRIKG-KASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRG 250
            |....::.|| .|.|.:||. |::....|              |...|...:..|..::.  .:.
pombe   402 NELAAIQTKGISAGKTEQLN-PQKETSRS--------------KTHTSRGENVEDRPQSL--LQN 449

Human   251 GGRPLL---GEAA-------------ELEDDEALEAL--------------APSSPLMYPSPASA 285
            |.:|::   |:.|             :..:::|::|:              |.::|....:.|:|
pombe   450 GIQPIIMRDGKLALNPEFFKNANGEQQAPNEQAVQAISLLQQHINKQLGPAAANNPEQATAIANA 514

Human   286 LSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDAYGPRARAGTPAYFGGCKGGAY 350
            |:.||..:..   .:..::.||..:.               |.|  .|.:|.|            
pombe   515 LAVALAQKLQ---KQQTQMQGPQQVQ---------------QQA--KRRKAYT------------ 547

Human   351 GGGGGFGPPAMGALRRLPMQTIQENKQASFVPAAAPFRPGALPALLPPPPP---APRPGPVLGAP 412
                                    ::|.:..|.|.|.     |.:..|.|.   ..||...:|.|
pombe   548 ------------------------SQQLNPAPTAMPH-----PNITSPSPSISVTQRPAVNVGPP 583

Human   413 GELALAGAAAAYPGKGAAPYA-PPAPS-----RSALAHPISLMTLPGEAGAAGLAPS 463
                              ||. |.|||     |.::..|:.    ||........||
pombe   584 ------------------PYVRPSAPSKLPDTRQSIGDPLP----PGAMANVSAGPS 618

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO6NP_001278210.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 12/65 (18%)
FH_FOXO6 89..176 CDD:410837 39/97 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..235 21/87 (24%)
FOXO_KIX_bdg 358..>382 CDD:465228 1/23 (4%)
FOXO-TAD 499..537 CDD:435506
fhl1NP_594272.1 COG5025 1..564 CDD:227358 92/434 (21%)
Blue background indicates that the domain is not in the aligned region.

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