Protein Alignment FOXO6 and sep1

DIOPT Version :10

• Sequence 1: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_596301.1
• Gene: sep1 / 2540866
• PomBaseID: SPBC4C3.12
• Length: 663
• Species: Schizosaccharomyces pombe
• Alignment Length: 665
• Identity: 146/665 - (21%)
• Similarity: 212/665 - (31%)
• Gaps: 224/665 - (33%)

Human    19 QSRPRSCTWPLPQPDLAGDEDGALGAGVAEG-AEDCGPERRATAPAMAPAPPLGAEVGPLRKAKS 82
            ||.|       |.|.:|....|.:..|.... |....|..:||.|.:.....|...|.||.....
pombe    36 QSLP-------PYPKVASKLKGVVAGGKENNIASFQKPSSKATRPYIPSYTRLTYSVPPLPIPPP 93

Human    83 SRRN----AWGN-------------------------LSYADLITKAIESAPDKRLTLSQIYDWM 118
            |.::    .:.|                         .|||.||..:|..:||:|||||.||||:
pombe    94 SEQSLDTIIYRNPSVSSSQSQEPEEFFLPLDDGKKPPYSYAMLIGMSIIRSPDRRLTLSAIYDWI 158

Human   119 VRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNEGT--GKSSWWMLNPEGGKTGKTPRRR 181
            .....::     :.|:.||:|||||||||:..|::::....  ||..:|.:.|
pombe   159 SNTFSFY-----NKSNNGWQNSIRHNLSLNKAFMKIERPRNLPGKGHFWSIRP------------ 206

Human   182 AVSMDNGAKFLRIKGKASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKWAASPAS---------- 236
                .:..:||::|            .|.|..:|..||....|.::.|:.:|..|
pombe   207 ----GHEEQFLKLK------------LRKPGVNSRPAPPVQDVTSSTKYGSSTGSSGFNTFNTSP 255

Human   237 --------------------------------HASDDYEAWADFRGGGRPLLGEAAELEDDEALE 269
                                            |.....:.:.|..|...|...| |:..|.....
pombe   256 HIFNQRHQYLQNYYTASLTNIPTISNVNATNFHPLHSQQPYVDTPGIDAPSDLE-AKFSDLGVSS 319

Human   270 ALAPSSPLM--YPSPASALSPALGSRCPGELPRLAELG----GPLGLHGGGG--AGLPEGLLDGA 326
            .::.:|||.  ..||:..||....|..|.|..|...||    ..|||:....  .|.|...|:
pombe   320 VVSVTSPLQSCTNSPSPPLSSPASSASPSESLRNESLGIKSAKSLGLNKDDAPVEGPPVSHLE-- 382

Human   327 QDAYGPRARAGTPAYFG-----GCKGGAYGGGGGFGPPAMGALRRLPMQTIQENKQASFVPAAAP 386
            :|...|........:..     |.||...|.......||:    |||.           :|::..
pombe   383 KDVETPSVHDSVLGFNDTVTNLGKKGLKDGTTNTLQIPAV----RLPS-----------LPSSPT 432

Human   387 FR-PGALPALL--------PPPPPAPRPGPV---------------LGAPGELALAGAAAAYPGK 427
            .: |..|  ||        |.||.|..|...               |.:|....::|.:|: |..
pombe   433 IKNPSGL--LLKRSNSIDFPTPPKALCPKLFCFRDDIVADDYTKFSLLSPIRSDMSGISAS-PNT 494

Human   428 GAAPY---------APPAPSRSALAH---------PI-SLMTLPGEAGAAGLAPSGHAAAFGGPP 473
            ....:         .|.|...|:|..         |: |.:...|:|       |........|.
pombe   495 NLKEHRTRILQMLATPDAKQLSSLTSSDAEFWSVTPLKSSILRNGDA-------SKQVTLSESPK 552

Human   474 GGLLLDALPGPY----AAAAAGPLGAAPDRFPADLDLDMFSGSLECDVESIILNDFMDSDEM--- 531
            |..|||.....|    .::.||.  ..|.:.|.....|.|.            :||:|..:|
pombe   553 GDSLLDGGSLSYFTNNISSVAGL--ETPSKLPMSKSFDTFE------------DDFLDPMDMLSF 603

Human   532 -----DFNFDSALPP 541
                 |||.:..:.|
pombe   604 ENHFSDFNSNRKVSP 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		15/57 (26%)
		FH_FOXO6	89..176	CDD:410837	35/113 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		13/71 (18%)
		FOXO_KIX_bdg	358..>382	CDD:465228	5/23 (22%)
		FOXO-TAD	499..537	CDD:435506	10/45 (22%)
sep1	NP_596301.1	COG5025	20..663	CDD:227358	146/665 (22%)