DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO6 and mei4

DIOPT Version :10

Sequence 1:NP_001278210.2 Gene:FOXO6 / 100132074 HGNCID:24814 Length:559 Species:Homo sapiens
Sequence 2:NP_595617.1 Gene:mei4 / 2540241 PomBaseID:SPBC32H8.11 Length:517 Species:Schizosaccharomyces pombe


Alignment Length:529 Identity:128/529 - (24%)
Similarity:193/529 - (36%) Gaps:164/529 - (31%)


- Green bases have known domain annotations that are detailed below.


Human    92 SYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQN 156
            |||.||..||..:.:|:||||.||.|:.....|:     .|...||:|||||||||:..||:|:.
pombe    85 SYATLIGLAILQSHNKQLTLSGIYTWIRNTFRYY-----LNHDGGWQNSIRHNLSLNKAFIKVEK 144

Human   157 -EG-TGKSSWWMLNPEGGKTGKTPR-RRAVSMDNGAKFLRIKGKASKKKQLQAPERSPDDSSPSA 218
             :| |.|..:|.::|:..:...:.| .|:.|.|:.:| .|...|..:.|.|...|          
pombe   145 PKGKTLKGHYWTIDPDHMQNFVSVRLHRSHSTDSNSK-KRPSSKCHEIKPLTTRE---------- 198

Human   219 PAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGEAAELEDDEALEALAPSS-------P 276
                 :|.|.|.:...:.::|......:.         ..|||:.:|.:..:...||       |
pombe   199 -----IPLARKRSRLNSFNSSTSTSGSSS---------NVAAEVSNDASQPSNQDSSLNSNIVKP 249

Human   277 LMYPSPASALS------PALGSRCPGELPRLAELGGPLGLHGGGGAGLPEGLLDGAQDA--YGPR 333
            .:.||...:.|      |...:....:||       .:..|       ...|.:...|:  |   
pombe   250 PLPPSNVQSNSSSSENVPKPNAETQEDLP-------TIDAH-------ESSLYENVNDSRLY--- 297

Human   334 ARAGTPAYFGGCKGGAYGGGGGFGPPAMGALR---------RLPMQTIQE----------NKQAS 379
               ..||    |:..|...|.....|  |.||         .||....:|          ::|:|
pombe   298 ---EVPA----CRNMALNTGYSDADP--GYLRTSFRSNSHNSLPYSANEEEDVLQADFLVSQQSS 353

Human   380 FVPAAAPFR-PGALPALLPPPPPAPRPG--------PVLG-------APGELALA--GAAAAYPG 426
            .|.:....| |.::|.....|.|. ||.        |..|       |||.....  .:.::|  
pombe   354 MVSSYVSSRDPHSMPYYRREPIPL-RPSSRFYEYTRPTYGRTDTSCSAPGAFCSTQINSPSSY-- 415

Human   427 KGAAPYAPPAPSRSALA------HPISLMTLPGEAGAAGLAPSGHAAAFGGPPGGLLLDALPGPY 485
               ..|:..|||...|:      |..||:.:|      .|.||...:....|...||.:.|    
pombe   416 ---INYSKCAPSSPTLSLQKHREHVKSLLYVP------DLTPSFDGSDPWNPSSQLLSEPL---- 467

Human   486 AAAAAGPLGAAPDRFPADLDLDMFSGSLECDVESIILNDFMDSDEMDFNFDSALPPPPPGLAGAP 550
                              .|...|..||: |:.|:..  |.||.|:  |.:|:      |.:.||
pombe   468 ------------------FDQHSFQSSLD-DLMSVTC--FRDSPEL--NHESS------GYSSAP 503

Human   551 --PPNQSWV 557
              |.|::::
pombe   504 LMPSNRAFI 512

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO6NP_001278210.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
FH_FOXO6 89..176 CDD:410837 36/85 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..235 15/72 (21%)
FOXO_KIX_bdg 358..>382 CDD:465228 9/42 (21%)
FOXO-TAD 499..537 CDD:435506 11/37 (30%)
mei4NP_595617.1 COG5025 1..517 CDD:227358 128/529 (24%)
Blue background indicates that the domain is not in the aligned region.

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