DRSC/TRiP Functional Genomics Resources

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Protein Alignment FOXO6 and daf-16

DIOPT Version :10

Sequence 1:NP_001278210.2 Gene:FOXO6 / 100132074 HGNCID:24814 Length:559 Species:Homo sapiens
Sequence 2:NP_001367893.1 Gene:daf-16 / 172981 WormBaseID:WBGene00000912 Length:541 Species:Caenorhabditis elegans


Alignment Length:496 Identity:145/496 - (29%)
Similarity:215/496 - (43%) Gaps:159/496 - (32%)


- Green bases have known domain annotations that are detailed below.


Human    79 KAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWKNSIRH 143
            |..::|||||||:|||:|||.||.::|:|||||:|:|:|||:.||||:|||||||||||||||||
 Worm   166 KKTTTRRNAWGNMSYAELITTAIMASPEKRLTLAQVYEWMVQNVPYFRDKGDSNSSAGWKNSIRH 230

Human   144 NLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRR---RAVSMDNGAKFLRIKGKASKKKQLQ 205
            |||||:||:|:||||.||||||::||: .|.|:.|||   |:.:::...|....|.:...||:::
 Worm   231 NLSLHSRFMRIQNEGAGKSSWWVINPD-AKPGRNPRRTRERSNTIETTTKAQLEKSRRGAKKRIK 294

Human   206 APERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLGE----AAELEDDE 266
              ||                     |...:.|::.:          |..:.|.    :.:|.||:
 Worm   295 --ER---------------------ALMGSLHSTLN----------GNSIAGSIQTISHDLYDDD 326

Human   267 ALEAL---APS-------SPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAGLPEG 321
            :::..   .||       |.|..|..:|.:|||:||....:|...:.:|..:       ..:|..
 Worm   327 SMQGAFDNVPSSFRPRTQSNLSIPGSSSRVSPAIGSDIYDDLEFPSWVGESV-------PAIPSD 384

Human   322 LLDGAQDAYGPRARAGTPAYFGGCKGGAYGGGGGFGPPAMGALRRLPMQTIQENKQASFVPAAAP 386
            ::|...     :.|.....:.||                        :|..||:|.....|.|  
 Worm   385 IVDRTD-----QMRIDATTHIGG------------------------VQIKQESKPIKTEPIA-- 418

Human   387 FRPGALPALLPPPPPAPRPGPVLGAPGEL-ALAGAAAAYPGKGAAPYAPPAPSRSALAHPI---- 446
                        |||:..         || ::.|:.|..|               .|.:||    
 Worm   419 ------------PPPSYH---------ELNSVRGSCAQNP---------------LLRNPIVPST 447

Human   447 --SLMTLPGEAG---AAGLAPSGHAAAFGGPPGGLLLDALPGPYAA--AAAGPLGAAPDRFPADL 504
              ..|.|||..|   ..|:.|....:.....|       |||..:.  .||....|:....|.||
 Worm   448 NFKPMPLPGAYGNYQNGGITPINWLSTSNSSP-------LPGIQSCGIVAAQHTVASSSALPIDL 505

Human   505 D---------LDMFSGSLECDVESIILNDFMDSDEMDFNFD 536
            :         :|..      ||:::|.::...:.....:||
 Worm   506 ENLTLPDQPLMDTM------DVDALIRHELSQAGGQHIHFD 540

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FOXO6NP_001278210.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76
FH_FOXO6 89..176 CDD:410837 63/86 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 163..235 18/74 (24%)
FOXO_KIX_bdg 358..>382 CDD:465228 4/23 (17%)
FOXO-TAD 499..537 CDD:435506 9/47 (19%)
daf-16NP_001367893.1 FH_FOXO 176..255 CDD:410806 60/78 (77%)
Blue background indicates that the domain is not in the aligned region.

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