Protein Alignment FOXO6 and foxo6

DIOPT Version :10

• Sequence 1: NP_001278210.2
• Gene: FOXO6 / 100132074
• HGNCID: 24814
• Length: 559
• Species: Homo sapiens
• Sequence 2: NP_001419944.1
• Gene: foxo6 / 100490156
• XenbaseID: XB-GENE-482993
• Length: 560
• Species: Xenopus tropicalis
• Alignment Length: 610
• Identity: 299/610 - (49%)
• Similarity: 351/610 - (57%)
• Gaps: 112/610 - (18%)

Human     9 QVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDGALGAGVAEGAEDCGPERRATAPAMAPAPPLGAE 73
            ::|.:.|..||.|||||||| |.||                           .|:..|.||.|.:
 Frog     4 KLDAESDVEPQGRPRSCTWP-PLPD---------------------------PPSDMPLPPPGLD 40

Human    74 VGPLRKAKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWMVRYVPYFKDKGDSNSSAGWK 138
            .|.:||||||||||||||||||||||||||:|::|||||||||||||:|||||||||||||||||
 Frog    41 PGQIRKAKSSRRNAWGNLSYADLITKAIESSPERRLTLSQIYDWMVRFVPYFKDKGDSNSSAGWK 105

Human   139 NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAVSMDN-GAKFLRIKGKASKKK 202
            ||||||||||||||||||||||||||||||||||||||||||||.|||| ..||:|:||||.|||
 Frog   106 NSIRHNLSLHTRFIRVQNEGTGKSSWWMLNPEGGKTGKTPRRRAASMDNANGKFIRMKGKAGKKK 170

Human   203 Q--LQAPERSPDDSSPSAPAPGPVPAAAKWAASPASHASDDYEAWADFRGGGRPLLG-------- 257
            |  ..||||:.:.|        |....|||:.||:||.|||:|.||:|.....|..|
 Frog   171 QQAQSAPERTVEGS--------PSSQHAKWSESPSSHTSDDFEVWAEFHSRSNPAAGNMSGRLSP 227

Human   258 -----EAAELEDDEALEALAPSSPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGGGGAG 317
                 |..:||||:    :|||||||||||:|||||:  :||..|:||||||.|.:||    |.|
 Frog   228 IIANDEPDDLEDDD----VAPSSPLMYPSPSSALSPS--NRCSVEMPRLAELTGTIGL----GEG 282

Human   318 LPEGLLDGAQDAY----GPRARAGTPAYFGGCK-------GGAYGGGGGFGPPAMGALRRLPMQT 371
            |.:.|||..||:|    |...|....|:....|       .||| .|..:..||||.:|||||||
 Frog   283 LADHLLDELQDSYPVGSGAALRHRNTAFSFSTKCPTLSPPSGAY-CGSIYSQPAMGMMRRLPMQT 346

Human   372 IQENKQASFVPAAAPFRPGALPALLPPPPPAPRPGPVLGAPGELALAGAAAAYP---------GK 427
            |||||||.: |..:.:|..::..||.......:.......||...:.|...::.         ..
 Frog   347 IQENKQAVY-PPGSTYRNSSIQDLLSAMSYGHKDSLGQSDPGLTNVLGPQRSHRQNIGMLGNCDS 410

Human   428 GAAPYAPPAPSRSALAHP--------------ISLMTLPGEAGAAGLAPSGHAAAFGGPPG-GLL 477
            |..||:.......:|.|.              ||...|...:.:..|..:.|...|....| |.|
 Frog   411 GPMPYSTGLMKSQSLYHQSTLNHHCSVNNSALISGSGLVNNSESCSLVSAQHHTYFSSQSGNGSL 475

Human   478 LDALPGPYAAA----AAGPLGAAPDRFPADLDLDMFSGSLECDVESIILNDFMDSDEMDFNFDSA 538
            ::   |||...    ...|.....||||.|||||||:|:|||||||||||||||:|||||||||:
 Frog   476 ME---GPYQPTYHHHHHHPQLYNQDRFPTDLDLDMFNGTLECDVESIILNDFMDNDEMDFNFDSS 537

Human   539 LPPPPPG----LAGAPPPNQSWVPG 559
            |  ||.|    ...:.|.|||||.|
 Frog   538 L--PPQGGFNMAVNSQPANQSWVQG 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FOXO6	NP_001278210.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..76		20/66 (30%)
		FH_FOXO6	89..176	CDD:410837	82/86 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	163..235		45/74 (61%)
		FOXO_KIX_bdg	358..>382	CDD:465228	18/23 (78%)
		FOXO-TAD	499..537	CDD:435506	33/37 (89%)
foxo6	NP_001419944.1	FH_FOXO6	56..143	CDD:410837	82/86 (95%)
		FOXO_KIX_bdg	328..404	CDD:465228	26/76 (34%)
		FOXO-TAD	498..537	CDD:435506	34/38 (89%)