DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZNF316 and ikzf1

DIOPT Version :9

Sequence 1:	NP_001265488.1	Gene:	ZNF316 / 100131017	HGNCID:	13843	Length:	1004	Species:	Homo sapiens
Sequence 2:	XP_005156674.1	Gene:	ikzf1 / 30177	ZFINID:	ZDB-GENE-980526-304	Length:	641	Species:	Danio rerio

Alignment Length:	678	Identity:	149/678 - (21%)
Similarity:	227/678 - (33%)	Gaps:	219/678 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   170 EEWERLEADQRGLYQEVMQENYGILVSLGYPIPKPDLIFRLEQGEEPWVPDSPRPEEGDIVTGVY 234
            |...|:|.::.   ||:.|            |...|......:|.|......|.||:....||:
Zfish   100 EYLHRMETEEA---QEMSQ------------ITGRDSPMNANEGGEDQDEAMPVPEDLSASTGL- 148

Human   235 TGAWFWTDDIEDHEEEDDEDFLAEV-----AEEENEPPGLWSAAYGVGDVPGTWGPDDSDSAQTP 294
                       .|....|:.....:     ::|||   ||.....|                :..
Zfish   149 -----------QHNNRTDKPLACNIKVEARSDEEN---GLSCEMNG----------------EAE 183

Human   295 EGWGPDPGGLGVLADGSEAKPFLPGREPGANLLSPWAFPAA--VAPPAGRPETTCDVCGKVFPHR 357
            |....|   |.:| |||.||  :.|...|.: ..|.|:|.|  :..|.|:  ..||:||.|
Zfish   184 ECAAED---LRIL-DGSGAK--VNGSHAGPD-SKPAAYPTAGGIRLPNGK--LKCDICGIV---- 235

Human   358 SRLAKHQRYHAAVKPFGCEECGKGFVYRSHLAIHQRTHT-----------GEKPFPCPDCGKRFV 411
                       .:.|             :.|.:|:|:||           ||:||.|..||..|.
Zfish   236 -----------CIGP-------------NVLMVHKRSHTEERKSVLEQQKGERPFQCNQCGASFT 276

Human   412 YKSHLVTHRRIHTGERPYRCAFCGAGFGRRSYLVTHQRTHTGERPYPCSHCGRSFSQSSALARHQ 476
            .|.:|:.|.::|:||:|::|..|.....||..|..|.|||:..:|:.|::||||:.|.|:|..|:
Zfish   277 QKGNLLRHIKLHSGEKPFKCHLCNYACRRRDALTGHLRTHSVGKPHKCAYCGRSYKQRSSLEEHK 341

Human   477 AVHTADRPHCCPDC----GQAFRLRADFQRH----------------RRGGGCAEAGGDGPRREP 521
                 :|.|....|    ...:.::.:..::                |.....|:.....|:|..
Zfish   342 -----ERCHNYLQCMGLQNSIYTVKEENSQNEQREDMPASERALVLDRIANNVAKRKSSMPQRFV 401

Human   522 GETAAAAGPEDTDPGPEGSEVGEADGEAEA----AAEEREEAAVA----------APTPSGKVDP 572
            ||...             ||:....|..|.    ..::...:|::          ..|..|..|.
Zfish   402 GENRL-------------SELSFESGSGELMQPHVIDQAINSAISYLGAESLRPLVQTSPGSADM 453

Human   573 APERRF------LELGNGLGEGEGPSSHPLGFHFPVHPKSWLHPDSFPILGLPDFRERLPVDGRP 631
            .....:      ...|||:...:..:.|.|                     |....:...||...
Zfish   454 VVSPLYNLHKSQTAEGNGVSAKDSAAEHLL---------------------LLSKSKSASVDKDG 497

Human   632 LPAPLGGPLSLVEGTGLACDPFGGGGAAGGG---------GGLRAFGPAIGGLLAEPAPAALAEE 687
            .|:|.|...:..|...........|.||.||         .|:|.     |||     |....|:
Zfish   498 SPSPSGQDSTDTESNNEERSAGVSGTAATGGLIYLTNHMAPGMRN-----GGL-----PGVKEEQ 552

Human   688 ESPWICSDCGKTFGRRAALAKHQRYHA----GE--RPHRCADCGKSF----VYGSHLARHRRTHT 742
            ...:   :..:..|...::|..:.:..    ||  |.:||..|...|    :|..|:..|
Zfish   553 HRQF---EALRAAGMDLSIASSEGFKVLSGDGEELRAYRCIHCRVLFLDHVMYTIHMGCH----- 609

Human   743 GER-PFPCPECGARFARGSHLAAHV-RG 768
            |.| ||.|..||.|.......::|: ||
Zfish   610 GFRDPFECNLCGYRSQDRYEFSSHITRG 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZNF316	NP_001265488.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..148
		KRAB	158..218	CDD:214630	10/47 (21%)
		COG5048	<345..503	CDD:227381	48/172 (28%)
		C2H2 Zn finger	347..367	CDD:275368	5/19 (26%)
		C2H2 Zn finger	375..395	CDD:275368	3/19 (16%)
		C2H2 Zn finger	403..423	CDD:275368	7/19 (37%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	9/19 (47%)
		C2H2 Zn finger	487..505	CDD:275368	1/37 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	508..574		13/79 (16%)
		C2H2 Zn finger	693..713	CDD:275368	2/19 (11%)
		zf-H2C2_2	705..730	CDD:316026	8/34 (24%)
		C2H2 Zn finger	721..741	CDD:275368	6/23 (26%)
		COG5048	<746..933	CDD:227381	9/24 (38%)
		C2H2 Zn finger	749..769	CDD:275368	7/21 (33%)
		C2H2 Zn finger	777..797	CDD:275368
		C2H2 Zn finger	805..825	CDD:275368
		C2H2 Zn finger	833..853	CDD:275368
		C2H2 Zn finger	861..881	CDD:275368
		C2H2 Zn finger	889..909	CDD:275368
		C2H2 Zn finger	917..937	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	936..976
ikzf1	XP_005156674.1	C2H2 Zn finger	229..249	CDD:275368	9/47 (19%)
		COG5048	<236..>339	CDD:227381	39/115 (34%)
		zf-H2C2_2	242..277	CDD:290200	13/34 (38%)
		zf-C2H2	266..288	CDD:278523	8/21 (38%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	280..305	CDD:290200	8/24 (33%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	312..333	CDD:290200	10/20 (50%)
		C2H2 Zn finger	324..345	CDD:275368	10/25 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910